专利检索 ap:("DSM Sinochem Pharmaceuticals Netherlands B.V.") AND inv:"MUELLER, Ulrike Maria" 第 1 页

1.

发明公开
MBTH-LIKE PROTEINS IN THE PRODUCTION OF SEMI SYNTHETIC ANTIBIOTICS 审中-公开
标题翻译： MBTH样蛋白在制造半合成抗生素

公开(公告)号：EP2809777A1

公开(公告)日：2014-12-10

申请号：EP13702014.5

申请日：2013-01-28

申请人： DSM Sinochem Pharmaceuticals Netherlands B.V.

发明人： MUELLER, Ulrike Maria , BOER, Rémon , BOVENBERG, Roelof, Ary, Lans

IPC分类号： C12N9/02 , C12P35/00 , C12P37/00

CPC分类号： C12P37/00 , C07K5/0806 , C12N9/0004 , C12N15/70 , C12Y121/03001

摘要： The present invention relates to the preparation of &bgr;-lactam antibiotics comprising contacting 4-hydroxyphenylglycine or phenylglycine, cysteine and valine with a non-ribosomal peptide synthetase and subsequent cyclization using an isopenicillin N synthase in the presence of an MbtH-like protein and to a host cell equipped to perform such preparation.