公开(公告)号：EP2300034B1

公开(公告)日：2018-08-08

申请号：EP09759182.0

申请日：2009-06-01

申请人： Dana-Farber Cancer Institute, Inc.

发明人： MUNSHI, Nikhil, C. ,  BAE, Jooeun ,  ANDERSON, Kenneth, C

IPC分类号： A61K38/00

CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K2039/55516 ,  A61K2039/55566 ,  C07K14/4702 ,  C07K14/70507 ,  Y02A50/471 ,  Y02A50/473

摘要： A pharmaceutical composition can be used for treating or preventing cancer; the composition comprising a pharmaceutically acceptable carrier and a peptide, a nucleic acid encoding said peptide, a vector comprising said nucleic acid, or a cell comprising said nucleic acid, peptide or vector; wherein said peptide consists of an amino acid sequence that is at least 66% identical to any one of SEQ ID NOS: 15-18.

公开(公告)号：EP3354265A1

公开(公告)日：2018-08-01

申请号：EP18157889.9

申请日：2006-03-22

申请人： President and Fellows of Harvard College ,  Dana Farber Cancer Institute, Inc.

发明人： ANDERSON, Kenneth, C ,  BRADNER, James, Elliott ,  GREENBERG, Edward, Franklin ,  HIDESHIMA, Teru ,  KWIATKOWSKI, Nicholas, Paul ,  MAZITSCHEK, Ralph ,  SCHREIBER, Stuart, L. ,  SHAW, Jared ,  HAGGARTY, Stephen, J

IPC分类号： A61K31/357 ,  A61K31/42 ,  A61K31/335 ,  A61K31/4965 ,  A61K45/06 ,  A61K31/35 ,  A61K31/39 ,  A61K31/69 ,  A61K38/55 ,  A61K49/00 ,  G01N33/50 ,  A61K31/422 ,  A61K38/50 ,  A61K38/05

CPC分类号： A61K38/05 ,  A61K31/35 ,  A61K31/357 ,  A61K31/422 ,  A61K31/4965 ,  A61K31/69 ,  A61K38/50 ,  A61K45/06 ,  A61K49/0008 ,  G01N33/5011 ,  A61K2300/00

摘要： The invention relates to methods of treating protein degradation disorders, such as cellular proliferative disorders (e.g., cancer). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating solid tumors. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.