公开(公告)号：EP4422634A2

公开(公告)日：2024-09-04

申请号：EP22812555.5

申请日：2022-10-27

申请人： Association Institut de Myologie ,  SORBONNE UNIVERSITE ,  Institut National de la Santé et de la Recherche Médicale (INSERM)

发明人： BENSALAH, Mona ,  BIGOT, Anne ,  MURAINE, Laura ,  NEGRONI, Elisa ,  TROLLET, Capucine

IPC分类号： A61K31/506 ,  A61K31/00 ,  A61K31/36 ,  A61K31/4025 ,  A61K31/405 ,  A61K31/422 ,  A61K31/496 ,  A61K31/505 ,  A61K45/06 ,  A61K48/00 ,  A61P21/00 ,  G01N33/74 ,  G01N33/68 ,  A01K67/027

CPC分类号： A61K31/506 ,  A61K31/4025 ,  A61K31/505 ,  A61K31/422 ,  A61K31/496 ,  A61K31/36 ,  A61K31/405 ,  A61K31/00 ,  A61K45/06 ,  G01N33/74 ,  A61P21/00 ,  G01N2333/575420130101 ,  G01N33/6893 ,  G01N2800/5220130101 ,  G01N2800/705220130101 ,  A01K67/0271 ,  A01K2207/1220130101 ,  A01K2207/1520130101

公开(公告)号：EP3416618A1

公开(公告)日：2018-12-26

申请号：EP17710810.7

申请日：2017-02-21

申请人： ZP Opco, Inc.

发明人： MAHMOUD, Ameri ,  KELLERMAN, Danald ,  DADDONA, Peter, E. ,  AO, Yi

IPC分类号： A61K9/00 ,  A61K31/00 ,  A61K47/12

CPC分类号： A61K9/0021 ,  A61K9/0014 ,  A61K31/422 ,  A61K47/12

摘要： Compositions, devices and methods employing therapeutic concentrations of a triptan for treatment of migraine are described. Also described are methods and apparatuses for delivery of zolmitriptan for achieving a Tmax as quick as 2 minutes and not later than 30 minutes in the majority of subjects.

公开(公告)号：EP2638021B1

公开(公告)日：2018-09-26

申请号：EP11839513.6

申请日：2011-11-10

申请人： Innocrin Pharmaceuticals, Inc.

发明人： HOEKSTRA, William, J. ,  SCHOTZINGER, Robert, J. ,  RAFFERTY, Stephen, William

IPC分类号： C07D249/04 ,  C07D401/06 ,  C07D413/10 ,  A61K31/4192 ,  A61K31/4725 ,  A61P35/00 ,  A61P9/00

CPC分类号： A61K31/4725 ,  A01N43/647 ,  A61K31/4192 ,  A61K31/422 ,  A61K31/4709 ,  A61K45/06 ,  C07D249/04 ,  C07D401/06 ,  C07D405/12 ,  C07D409/14 ,  C07D413/10 ,  C07D413/12 ,  A61K2300/00

摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

公开(公告)号：EP3030568B1

公开(公告)日：2018-09-19

申请号：EP14749783.8

申请日：2014-08-05

申请人： Galapagos NV

发明人： VAN DER PLAS, Steven Emiel ,  MARTINA, Sébastien Laurent Xavier ,  DROPSIT-MONTOVERT, Sébastien Jean-Jacques Cédric ,  ANDREWS, Martin James Inglis ,  KELGTERMANS, Hans

IPC分类号： C07D495/04 ,  A61K31/38

CPC分类号： A61K31/381 ,  A61K31/38 ,  A61K31/4025 ,  A61K31/4155 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/427 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/497 ,  A61K31/501 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K31/675 ,  C07D495/04 ,  C07F7/0812 ,  C07F9/091 ,  C07F9/6561

摘要： wherein R1 is as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment cystic fibrosis by administering a compound of the invention.

公开(公告)号：EP2970265B1

公开(公告)日：2018-08-08

申请号：EP14715529.5

申请日：2014-03-14

申请人： PLEXXIKON INC.

发明人： ZHANG, Jiazhong ,  BUELL, John ,  CHAN, Katrina ,  IBRAHIM, Prabha, N. ,  LIN, Jack ,  PHAM, Phuongly ,  SHI, Songyuan ,  SPEVAK, Wayne ,  WU, Guoxian ,  WU, Jeffrey

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07F9/6561 ,  A61K31/422 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61K31/675 ,  A61K31/695 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07F7/10 ,  Y02A50/411

摘要： Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.

公开(公告)号：EP3354265A1

公开(公告)日：2018-08-01

申请号：EP18157889.9

申请日：2006-03-22

申请人： President and Fellows of Harvard College ,  Dana Farber Cancer Institute, Inc.

发明人： ANDERSON, Kenneth, C ,  BRADNER, James, Elliott ,  GREENBERG, Edward, Franklin ,  HIDESHIMA, Teru ,  KWIATKOWSKI, Nicholas, Paul ,  MAZITSCHEK, Ralph ,  SCHREIBER, Stuart, L. ,  SHAW, Jared ,  HAGGARTY, Stephen, J

IPC分类号： A61K31/357 ,  A61K31/42 ,  A61K31/335 ,  A61K31/4965 ,  A61K45/06 ,  A61K31/35 ,  A61K31/39 ,  A61K31/69 ,  A61K38/55 ,  A61K49/00 ,  G01N33/50 ,  A61K31/422 ,  A61K38/50 ,  A61K38/05

CPC分类号： A61K38/05 ,  A61K31/35 ,  A61K31/357 ,  A61K31/422 ,  A61K31/4965 ,  A61K31/69 ,  A61K38/50 ,  A61K45/06 ,  A61K49/0008 ,  G01N33/5011 ,  A61K2300/00

摘要： The invention relates to methods of treating protein degradation disorders, such as cellular proliferative disorders (e.g., cancer). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating solid tumors. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.

公开(公告)号：EP3233846A4

公开(公告)日：2018-07-18

申请号：EP15869419

申请日：2015-12-16

申请人： ZENITH EPIGENETICS LTD

发明人： KHARENKO OLESYA ,  YOUNG PETER RONALD ,  BROWN SAMUEL DAVID ,  DUFFY BRYAN CORDELL ,  LIU SHUANG ,  GUZZO PETER

IPC分类号： C07D413/14 ,  A61K31/42 ,  A61K31/437 ,  A61K31/4439 ,  A61P3/00 ,  A61P9/00 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D471/04

CPC分类号： A61K31/422 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/437 ,  A61K31/4439 ,  A61K45/05 ,  A61K45/06 ,  A61K2300/00 ,  A61P3/00 ,  A61P9/00 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D261/06 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  Y02A50/467

摘要： The present disclosure relates to compounds capable of acting as covalent inhibitors of bromodomains and the therapeutic use of these inhibitors.

公开(公告)号：EP3342765A1

公开(公告)日：2018-07-04

申请号：EP16840786.4

申请日：2016-08-26

申请人： Sunshine Lake Pharma Co., Ltd.

发明人： WANG, Xiaojun ,  ZHOU, Pingjian ,  YANG, Chuanwen ,  HUANG, Changwei ,  XIONG, Shaohui ,  ZHANG, Yingjun ,  ZHANG, Jiancun

IPC分类号： C07C255/29 ,  C07C255/46 ,  C07C209/42 ,  C07C215/48 ,  C07C233/54 ,  C07C277/02 ,  A61K31/275

CPC分类号： C07D407/10 ,  A61K31/275 ,  A61K31/343 ,  A61K31/351 ,  A61K31/357 ,  A61K31/36 ,  A61K31/38 ,  A61K31/381 ,  A61K31/382 ,  A61K31/39 ,  A61K31/397 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/443 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07C209/42 ,  C07C215/48 ,  C07C233/54 ,  C07C255/29 ,  C07C255/46 ,  C07C277/02 ,  C07D307/85 ,  C07D405/10 ,  C07D407/12 ,  C07D407/14 ,  C07D409/10 ,  C07D411/10 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04 ,  C07D493/04

摘要： The invention relates to capthepsin K inhibitors and uses thereof, specifically relates to a class of compounds having the formula (I) which are used for treating or preventing cathepsin dependent diseases or conditions, specifically, wherein the cathepsin is capthepsin K. The compounds and compositions thereof can be used as bone resorption inhibitors for the treatment of associated diseases.

公开(公告)号：EP2491926B1

公开(公告)日：2018-05-09

申请号：EP12150229.8

申请日：2006-03-22

申请人： President and Fellows of Harvard College ,  Dana-Farber Cancer Institute, Inc.

发明人： Anderson, Kenneth, C. ,  Bradner, James, Elliott ,  Greenberg, Edward, Franklin ,  Hideshima, Teru ,  Kwiatkowski, Nicholas, Paul ,  Mazitschek, Ralph ,  Schreiber, Stuart, L. ,  Shaw, Jared ,  Haggarty, Stephen, J

IPC分类号： A61K31/357 ,  A61K31/42 ,  A61K31/335 ,  A61K31/4965 ,  A61K45/06 ,  A61K31/35 ,  A61K31/39 ,  A61K31/69 ,  A61K38/55 ,  A61K49/00 ,  G01N33/50 ,  A61K38/50 ,  A61K31/422 ,  A61K38/05

CPC分类号： A61K38/05 ,  A61K31/35 ,  A61K31/357 ,  A61K31/422 ,  A61K31/4965 ,  A61K31/69 ,  A61K38/50 ,  A61K45/06 ,  A61K49/0008 ,  G01N33/5011 ,  A61K2300/00

摘要： The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.

公开(公告)号：EP3313400A1

公开(公告)日：2018-05-02

申请号：EP16733385.5

申请日：2016-06-22

申请人： Intervet International B.V.

发明人： FLOCHLAY-SIGOGNAULT, Annie ,  LEHAY, Anne

IPC分类号： A61K31/42 ,  A61P33/00

CPC分类号： A61K31/42 ,  A61K31/355 ,  A61K31/422 ,  A61P33/00

摘要： For the prevention of parasite infestation of animals, an isoxazoline can be administered by drinking water route. However the inventors have found that when the drinking water is sanitized, for instance by using hypochlorite, the isoxazoline becomes degraded. Surprisingly, the isoxazoline can be protected from degradation by the use of a vitamin E. A pharmaceutical composition can now be prepared containing a concentrated solution of the isoxazoline in a solvent and co-solvent, with vitamin E. The composition can be diluted in drinking water, even when sanitized, to prepare medicated drinking water for animals. This way an anti-parasitic treatment can be mass-administered, leading to a highly effective reduction of the parasite infestation of an animal, and its surroundings.