公开(公告)号：EP1608679A1

公开(公告)日：2005-12-28

申请号：EP04725368.7

申请日：2004-04-02

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts ,  Ruprecht-Karls-Universität Heidelberg

发明人： PONSTINGL, Herwig ,  ZIMMERMANN, Hans-Peter ,  MOLDENHAUER, Gerhard ,  MARM , Alexander ,  Bastert, Gunther ,  Kurek, Raffael ,  Wallwiener, Diethelm

IPC分类号： C07K14/435 ,  C12N15/12 ,  C12N15/63 ,  C12N15/74 ,  C12N15/79 ,  A01K67/027 ,  A61K38/17 ,  A61K48/00 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C07K14/4708 ,  A01K2217/05 ,  C07K2319/60

摘要： Described is a novel marker protein associated with epithelial tumors, e.g., ovarian, mammary, stomach, kidney, thyroid and lung carcinomas, Dropl, a dystrophin-related protein as well as a nucleic acid molecule encoding Dropl. Furthermore, various diagnostic and therapeutic uses based on the finding that the expression of Dropl is downregulated in epithelial tumors are described.

公开(公告)号：EP0967997B1

公开(公告)日：2003-11-19

申请号：EP98924027.0

申请日：1998-03-18

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： GRANZOW, Christof ,  PONSTINGL, Herwig ,  HEFFT, Irmgard ,  KOPUN-GRANZOW, Marijana ,  GROS, Gabriele ,  STÖHR, Michael

IPC分类号： A61K41/00 ,  A61K38/13 ,  A61K31/475 ,  A61K45/06 ,  A61K31/275

CPC分类号： A61K45/06 ,  A61K31/275 ,  A61K38/13 ,  A61K2300/00

摘要： The invention relates to a pharmaceutical composition containing an inhibitor for membrane pumps and a photoaffinity-marked chemotherapeutic agent. Said composition is suitable for eliminating membrane-mediated cell resistance, especially membrane-mediated multi-chemo-resistance of tumor cells.