公开(公告)号：EP2139558A1

公开(公告)日：2010-01-06

申请号：EP07724332.7

申请日：2007-04-18

申请人： Elekta AB (PUBL)

发明人： BROWN, Kevin, John

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61N5/103 ,  A61N5/1067 ,  A61N5/1084 ,  A61N2005/1061

摘要： A treatment planning apparatus for radiation treatment is described, adapted to accept a treatment plan comprising (i) a prior image of a region to be treated and a plurality of dose locations within the prior image, and (ii) a current image of the region to be treated, the apparatus comprising an associating means arranged, for each dose location, to locate an anatomical structure in the prior image proximate that dose location; a comparator for comparing the prior image and the current image, locating in the current image at least those anatomical structures that are associated with a dose location, and determining a transformation between the prior image and the current image for each anatomical structure; and a processing means for determining a current dose location by applying to each dose location the transformation determined in respect of the associated anatomical structure. This is particularly useful for the neck region of a patient, where the likelihood and magnitude of movements are both high, but there are plenty of distinguishable anatomical features in the form of the vertebrae.

公开(公告)号：EP1364375B1

公开(公告)日：2014-04-09

申请号：EP02702483.5

申请日：2002-02-27

申请人： Elekta AB (publ)

发明人： BROWN, Kevin, John ,  JAFFRAY, David, Anthony

IPC分类号： G21K1/04

CPC分类号： A61N5/1042 ,  A61N5/1047 ,  G21K1/04 ,  G21K1/046

公开(公告)号：EP2229805B1

公开(公告)日：2011-10-12

申请号：EP07857056.1

申请日：2007-12-21

申请人： Elekta AB (PUBL) ,  The Institute of Cancer Research

发明人： BROWN, Kevin, John ,  THOMPSON, Maria, Giulia ,  ROBERTS, David, Anthony ,  EVANS, Philip, Mark ,  HANSEN, Vibeke, Nordmark

IPC分类号： H05H9/04

CPC分类号： H05H7/12 ,  H01J35/00 ,  H01J2235/08 ,  H05H6/00 ,  H05H9/04

摘要： X-ray apparatus comprises a linear accelerator adapted to produce a beam of electrons at one of at least two selectable energies and being controlled to change the selected energy on a periodic basis, and a target to which the beam is directed thereby to produce a beam of x-radiation, the target being non- homogenous and being driven to move periodically in synchrony with the change of the selected energy. In this way, the target can move so that a different part is exposed to the electron beam when different pulses arrive. This enables the appropriate target material to be employed depending on the selected energy. The easiest form of periodic movement for the target is likely to be a rotational movement. The target can be immersed in a coolant fluid such as water. The linear accelerator can be of the type disclosed in WO2006/097697A1. The target preferably contains at least one exposed area of tungsten and/or at least one exposed area of carbon. These can be present as inhomogeneities in the material of which the target is composed, such as Carbon inserts in a Tungsten substrate (or vice versa), alternating segments of Carbon and Tungsten, Carbon and Tungsten inserts in a substrate of a third material, or arrangements involving other materials in addition to or instead of Carbon and/or Tungsten. Alternatively, the target can be of a homogenous material but have inhomogeneities in its thickness to cater for the different electron energies. The same concept can be applied to the filter. A detector can be provided, operating in synchrony with the energy variation. Such an x-ray apparatus can form a part of a radiotherapy apparatus, in which case the first selected energy can be a diagnostic energy and a second selected energy a therapeutic energy.

公开(公告)号：EP2229805A1

公开(公告)日：2010-09-22

申请号：EP07857056.1

申请日：2007-12-21

申请人： Elekta AB (PUBL) ,  The Institute of Cancer Research

发明人： BROWN, Kevin, John ,  THOMPSON, Maria, Giulia ,  ROBERTS, David, Anthony ,  EVANS, Philip, Mark ,  HANSEN, Vibeke, Nordmark

IPC分类号： H05H9/04

CPC分类号： H05H7/12 ,  H01J35/00 ,  H01J2235/08 ,  H05H6/00 ,  H05H9/04

摘要： X-ray apparatus comprises a linear accelerator adapted to produce a beam of electrons at one of at least two selectable energies and being controlled to change the selected energy on a periodic basis, and a target to which the beam is directed thereby to produce a beam of x-radiation, the target being non- homogenous and being driven to move periodically in synchrony with the change of the selected energy. In this way, the target can move so that a different part is exposed to the electron beam when different pulses arrive. This enables the appropriate target material to be employed depending on the selected energy. The easiest form of periodic movement for the target is likely to be a rotational movement. The target can be immersed in a coolant fluid such as water. The linear accelerator can be of the type disclosed in WO2006/097697A1. The target preferably contains at least one exposed area of tungsten and/or at least one exposed area of carbon. These can be present as inhomogeneities in the material of which the target is composed, such as Carbon inserts in a Tungsten substrate (or vice versa), alternating segments of Carbon and Tungsten, Carbon and Tungsten inserts in a substrate of a third material, or arrangements involving other materials in addition to or instead of Carbon and/or Tungsten. Alternatively, the target can be of a homogenous material but have inhomogeneities in its thickness to cater for the different electron energies. The same concept can be applied to the filter. A detector can be provided, operating in synchrony with the energy variation. Such an x-ray apparatus can form a part of a radiotherapy apparatus, in which case the first selected energy can be a diagnostic energy and a second selected energy a therapeutic energy.

公开(公告)号：EP1325503A1

公开(公告)日：2003-07-09

申请号：EP01967515.6

申请日：2001-09-19

申请人： Elekta AB (publ)

发明人： BROWN, Kevin, John ,  STREAMER, Ralph, Peter

IPC分类号： G21K1/04

CPC分类号： G21K1/046 ,  A61N5/1042 ,  A61N5/1045 ,  A61N2005/1095 ,  G21K1/04

摘要： A collimator set for a radiotherapy apparatus comprises, in sequence, an aperture collimator, a multi-leaf collimator with a pair of opposing arrays of elongate leaves each moveable longitudinally in a Y direction, and a leaf edge collimator, the aperture collimator being adapted to collimate the beam in the X and Y direction to a first extent, and the leaf edge collimator being adapted to further collimate the extent of the beam in the Y direction to a second and therefore lesser extend. This means that to close a pair of opposing leaves, they are moved to their minimum separation, with the gap being convered by the leaf edge collimator. The MLC is after the aperture collimator, so in combination with thin leaves, the MLC leaves will project a much reduced leaf width at the isocentre of the radiotherapy apparatus and collimation of the radiation field by fractional leaf widths becomes unnecessary. A radiotherapy apparatus comprising a collimator set as defined above is also disclosed.

公开(公告)号：EP1589876B1

公开(公告)日：2011-10-19

申请号：EP04703444.2

申请日：2004-01-20

申请人： Elekta AB (publ)

发明人： BROWN, Kevin, John ,  JAFFRAY, David ,  SIEWERDSEN, Jeffrey ,  VAN HERK, Marcel ,  SONKE, Jan-Jakob

IPC分类号： A61B6/03 ,  A61B5/113 ,  A61N5/10

CPC分类号： A61B6/541 ,  A61B6/032 ,  G06T11/005 ,  G06T2211/412

摘要： Artefacts in the reconstructed volume data of cone beam CT systems can be removed by the application of respiration correlation techniques to the acquired projection images. To achieve this, the phase of the patients breathing is monitored while acquiring projection images continuously. On completion of the acquisition, projection images that have comparable breathing phases can be selected from the complete set, and these are used to reconstruct the volume data using similar techniques to those of conventional CT. Any phase can be selected and therefore the effect of breathing can be studied. It is also possible to use a feature in the projection image(s) such as the patient's diaphragm to determine the breathing phase. This feature in the projection images can be used to control delivery of therapeutic radiation dependent on the patient's breathing cycle, to ensure that the tumour is in the correct position when the radiation is delivered.

公开(公告)号：EP1589876A1

公开(公告)日：2005-11-02

申请号：EP04703444.2

申请日：2004-01-20

申请人： Elekta AB (publ)

发明人： BROWN, Kevin, John ,  JAFFRAY, David ,  SIEWERDSEN, Jeffrey ,  VAN HERK, Marcel ,  SONKE, Jan-Jakob

IPC分类号： A61B6/03 ,  A61B5/113 ,  A61N5/10

CPC分类号： A61B6/541 ,  A61B6/032 ,  G06T11/005 ,  G06T2211/412

摘要： Artefacts in the reconstructed volume data of cone beam CT systems can be removed by the application of respiration correlation techniques to the acquired projection images. To achieve this, the phase of the patients breathing is monitored while acquiring projection images continuously. On completion of the acquisition, projection images that have comparable breathing phases can be selected from the complete set, and these are used to reconstruct the volume data using similar techniques to those of conventional CT. Any phase can be selected and therefore the effect of breathing can be studied. It is also possible to use a feature in the projection image(s) such as the patient's diaphragm to determine the breathing phase. This feature in the projection images can be used to control delivery of therapeutic radiation dependent on the patient's breathing cycle, to ensure that the tumour is in the correct position when the radiation is delivered.

公开(公告)号：EP1045719B1

公开(公告)日：2001-11-14

申请号：EP98959026.0

申请日：1998-12-10

申请人： ELEKTA AB

发明人： BROWN, Kevin, John

IPC分类号： A61N5/01

CPC分类号： A61B6/0457 ,  A61N5/10

摘要： Apparatus for treatment by radiotherapy, comprises a patient table, a directional radiation source directed generally toward the patient table, the table and source being movable relative to each other at least axially with respect to the table and rotationally around the axis, the source being directionally adjustable within at least a plane including the longitudinal axis of the table, and including means to correlate axial relative motion of the table and directional adjustment of the source. Thus, the source of such an apparatus can be rotated about the table to access the predetermined position along a series of cones centred on the predetermined position and of the variable angle. Thus, the apparatus effectively accesses the predetermined position via lines of latitude rather than longitude. It is preferred if the source is directionally adjustable across an included angle of at least 20°, preferably more than 30°. The source can be (for example) held within a ring member centred substantially on the patient table.

公开(公告)号：EP2326390B1

公开(公告)日：2013-12-11

申请号：EP09784773.5

申请日：2009-07-24

申请人： Elekta AB (publ)

发明人： JAFFRAY, David, A. ,  BROWN, Kevin, John ,  BOOTSMA, Gregory ,  RUSCHIN, Mark ,  CARLSSON, Per

IPC分类号： A61N5/10

CPC分类号： A61N5/1084 ,  A61N5/1065 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1063 ,  A61N2005/1097

摘要： A highly compact, high-performance volumetric imaging system is proposed, that is integrated with a multi-source Cobalt-60 gamma irradiator for high throughput, high accuracy and minimally invasive fractioned treatments of intracranial, orbital and head-and-neck targets.

公开(公告)号：EP2326390A1

公开(公告)日：2011-06-01

申请号：EP09784773.5

申请日：2009-07-24

申请人： Elekta AB (publ)

发明人： JAFFRAY, David, A. ,  BROWN, Kevin, John ,  BOOTSMA, Gregory ,  RUSCHIN, Mark ,  CARLSSON, Per

IPC分类号： A61N5/10

CPC分类号： A61N5/1084 ,  A61N5/1065 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1063 ,  A61N2005/1097

摘要： A highly compact, high-performance volumetric imaging system is proposed, that is integrated with a multi-source Cobalt-60 gamma irradiator for high throughput, high accuracy and minimally invasive fractioned treatments of intracranial, orbital and head-and-neck targets.