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公开(公告)号：EP2691399B1
公开(公告)日：2016-07-13
申请号：EP12710724.1
申请日：2012-03-26
发明人： HERMANN, Johannes Cornelius , LOWRIE, JR., Lee Edwin , LUCAS, Matthew C. , LUK, Kin-Chun Thomas , PADILLA, Fernando , WANNER, Jutta , XIE, Wenwei , ZHANG, Xiaohu
IPC分类号： C07D513/04 , A61K31/519 , A61P19/02
CPC分类号： C07D513/04 , A61K45/06
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公开(公告)号：EP2864335A1
公开(公告)日：2015-04-29
申请号：EP13729366.8
申请日：2013-06-18
发明人： BOLIN, David Robert , DE VICENTE FIDALGO, Javier , HERMANN, Johannes Cornelius , TIVITMAHAISOON, Parcharee , YI, Lin , ZAK, Mark
IPC分类号： C07D491/052 , C07D491/147 , C07D491/153 , C07D495/14
CPC分类号： C07D491/052 , C07D491/107 , C07D491/147 , C07D491/153 , C07D495/14
摘要： There are provided compounds of the formula or a pharmaceutically acceptable salt thereof wherein X, M, Y, R
1 and R
2 are as defined herein. The compounds have activity as anticancer agents.摘要翻译： 提供下式的化合物或其药学上可接受的盐，其中X，M，Y，R 1和R 2如本文所定义。 该化合物具有抗癌剂的活性。
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公开(公告)号：EP2864330A1
公开(公告)日：2015-04-29
申请号：EP13729367.6
申请日：2013-06-18
IPC分类号： C07D487/04 , A61K31/495 , A61K31/4985 , A61P35/00
CPC分类号： C07D487/04
摘要： There are provided compounds of the formula (I), wherein R
1 and R
2 are as described herein. The compounds are useful as inhibitors of tankyrase in the treatment of cancer.摘要翻译： 提供了式（I）的化合物，其中R 1和R 2如本文所述。 该化合物可用作治疗癌症的坦科聚合酶抑制剂。
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4.发明公开PYRAZOLOPYRIMIDONE AND PYRAZOLOPYRIDONE INHIBITORS OF TANKYRASE 审中-公开端锚聚合酶PYRAZOLOPYRIMIDON-和pyrazolopyridone抑制剂
公开(公告)号：EP2858994A1
公开(公告)日：2015-04-15
申请号：EP13726537.7
申请日：2013-06-04
发明人： FENG, Jianwen , HAYNES, Nancy-Ellen , HERMANN, Johannes Cornelius , KIM, Kyungjin , LIU, Jin-Jun , SCOTT, Nathan Robert , YI, Lin , ZAK, Mark , ZHAO, Guiling
IPC分类号： C07D487/04 , A61K31/437 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04
摘要： There are provided compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein Q, R
1 and R
2 are as defined herein. The compounds of formula I are useful in the treatment of cancer.-
公开(公告)号：EP2571881A1
公开(公告)日：2013-03-27
申请号：EP11721743.0
申请日：2011-05-17
发明人： HENDRICKS, Robert Than , HERMANN, Johannes Cornelius , KONDRU, Rama K. , LOU, Yan , LYNCH, Stephen M. , OWENS, Timothy D. , SOTH, Michael , YEE, Calvin Wesley
IPC分类号： C07D487/04 , A61K31/4965 , A61K31/497 , A61P29/00 , A61P37/00 , A61P35/00 , A61P25/00 , A61P9/00 , A61P3/00 , A61P11/00 , A61P19/00
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula (I), wherein the variables Q and R
1 and R
2 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.摘要翻译： 本发明涉及式（I）的新型吡咯并吡嗪衍生物的用途，其中变量Q和R 1和R 2如本文所述定义，其抑制JAK和SYK并可用于治疗自身免疫和炎症 疾病。
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公开(公告)号：EP2763990A1
公开(公告)日：2014-08-13
申请号：EP12761923.7
申请日：2012-08-27
发明人： CHEN, Shaoqing , DE VICENTE FIDALGO, Javier , HAMILTON, Matthew Michael , HERMANN, Johannes Cornelius , KENNEDY-SMITH, Joshua , LI, Hongju , LOVEY, Allen John , LUCAS, Matthew C. , LUK, Kin-Chun Thomas , LYNCH, Stephen M. , O'YANG, Counde , PADILLA, Fernando , SCHOENFELD, Ryan Craig , SIDDURI, Achyutharao , SOTH, Michael , WANG, Ce , WOVKULICH, Peter Michael , ZHANG, Xiaohu
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/5025 , A61P29/00
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量如本文所述定义，其抑制JAK和SYK并可用于治疗自身免疫和炎性疾病。
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7.发明公开PYRROLOPYRAZINE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS 审中-公开PYRROLOPYRAZINDERIVATE及其作为JAK和SYK抑制剂的用途
公开(公告)号：EP2550274A1
公开(公告)日：2013-01-30
申请号：EP11711062.7
申请日：2011-03-21
发明人： HENDRICKS, Robert Than , HERMANN, Johannes Cornelius , KONDRU, Rama, K. , LOU, Yan , LYNCH, Stephen, M. , OWENS, Timothy, D. , SOTH, Michael
IPC分类号： C07D487/04 , A61K31/4985 , A61P29/00 , A61P37/02 , A61P37/08
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula (I), wherein the variables Q, R2, R3, and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
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公开(公告)号：EP2550273A2
公开(公告)日：2013-01-30
申请号：EP11711061.9
申请日：2011-03-18
发明人： HENDRICKS, Robert Than , HERMANN, Johannes Cornelius , KONDRU, Rama K. , LOU, Yan , LYNCH, Stephen M. , OWENS, Timothy D. , SOTH, Michael
IPC分类号： C07D487/04 , C07D519/00 , A61K31/4985 , A61P29/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula (I), wherein the variables n, p, q, Q, X, X' and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
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公开(公告)号：EP2888262A1
公开(公告)日：2015-07-01
申请号：EP13750700.0
申请日：2013-08-19
发明人： HERMANN, Johannes Cornelius , KENNEDY-SMITH, Joshua , LUCAS, Matthew C. , PADILLA, Fernando , SCHOENFELD, Ryan Craig , WOVKULICH, Peter Michael
IPC分类号： C07D487/04 , A61K31/4985 , A61P37/00 , A61P37/06 , A61P35/00 , A61P25/28 , A61P3/10 , C07D519/00
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/506 , A61K45/06 , C07D471/04 , C07D519/00
摘要： The present invention relates to the use of novel pyrrolo[2,3-b]]pyrazines wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
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公开(公告)号：EP2773645A1
公开(公告)日：2014-09-10
申请号：EP12783182.4
申请日：2012-10-29
发明人： HERMANN, Johannes Cornelius , KUGLSTATTER, Andreas , LUCAS, Matthew C. , PADILLA, Fernando , WANNER, Jutta , ZHANG, Xiaohu
IPC分类号： C07D487/04 , A61K31/5025 , A61P29/00 , A61P19/02 , A61P17/06 , A61P3/10 , A61P37/00 , A61P11/06 , A61P25/28 , A61P35/00 , A61P35/02
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/5377 , A61K31/625 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of novel compounds of formula (I): wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式（I）的新化合物的用途：其中所有可变取代基如本文所述定义，其为SYK抑制剂且可用于治疗自身免疫和炎性疾病。
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