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10 条记录 (耗时 0.035 秒)

    TETRAHYDROQUINAZOLINE DERIVATIVES AS CFR ANTAGONISTS
    2.
    发明授权
    TETRAHYDROQUINAZOLINE DERIVATIVES AS CFR ANTAGONISTS 有权
    TETRAHYDROCHINAZOLINDERIVATE ALS CFR拮抗剂

    公开(公告)号：EP1656354B1

    公开(公告)日：2007-09-26

    申请号：EP04763724.4

    申请日：2004-08-03

    申请人： F.HOFFMANN-LA ROCHE AG

    发明人： CLARK, Robin, Douglas ,  COURNOYER, Richard, Leo ,  O'YANG, Counde

    IPC分类号： C07D239/94 ,  A61K31/517 ,  A61P25/24

    CPC分类号： C07D239/94

    摘要： Compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein m, R1, R2, R3 R4 and R6 are as defined herein. The invention also provides methods for preparing, compositions comprising the compounds of Formula (I), as well as their uses for the manufacture of medicaments useful in the treatment of diseases such as phobias, stress-related illnesses, mood disorders, eating disorders, generalized anxiety disorders, stress-induced gastrointestinal dysfunctions, neurodegenerative diseases, and neuropsychiatric disorders.

    TETRAHYDROQUINAZOLINE DERIVATIVES AS CFR ANTAGONISTS
    6.
    发明公开
    TETRAHYDROQUINAZOLINE DERIVATIVES AS CFR ANTAGONISTS 有权
    作为CFR拮抗剂的四氢喹喔啉衍生物

    公开(公告)号：EP1656354A1

    公开(公告)日：2006-05-17

    申请号：EP04763724.4

    申请日：2004-08-03

    申请人： F.HOFFMANN-LA ROCHE AG

    发明人： CLARK, Robin, Douglas ,  COURNOYER, Richard, Leo ,  O'YANG, Counde

    IPC分类号： C07D239/94 ,  A61K31/517 ,  A61P25/24

    CPC分类号： C07D239/94

    摘要： Compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein m, R1, R2, R3 R4 and R6 are as defined herein. The invention also provides methods for preparing, compositions comprising the compounds of Formula (I), as well as their uses for the manufacture of medicaments useful in the treatment of diseases such as phobias, stress-related illnesses, mood disorders, eating disorders, generalized anxiety disorders, stress-induced gastrointestinal dysfunctions, neurodegenerative diseases, and neuropsychiatric disorders.

    摘要翻译： 式（I）化合物及其药学上可接受的盐，其中m，R1，R2，R3，R4和R6如本文所定义。 本发明还提供了用于制备包含式（I）化合物的组合物的方法以及其用于制造用于治疗诸如恐怖症，压力相关疾病，情绪障碍，进食障碍，广义化 焦虑症，压力诱导的胃肠功能障碍，神经退行性疾病和神经精神障碍。

    PYRAZOLYL AND IMIDAZOLYL PYRIMIDINES
    9.
    发明公开
    PYRAZOLYL AND IMIDAZOLYL PYRIMIDINES 审中-公开
    吡唑基和咪唑基嘧啶

    公开(公告)号：EP1689740A1

    公开(公告)日：2006-08-16

    申请号：EP04819594.5

    申请日：2004-11-16

    申请人： F.HOFFMANN-LA ROCHE AG

    发明人： JAHANGIR, Alam ,  O'YANG, Counde

    IPC分类号： C07D403/04 ,  A61K31/506 ,  A61P25/00

    CPC分类号： C07D403/04

    摘要： Compounds of the formula (I), and pharmaceutically acceptable salts thereof, wherein X, Y, Z and R1 are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds of formula I for preparing medicaments.

    摘要翻译： 式（I）化合物及其药学上可接受的盐，其中X，Y，Z和R 1如本文所定义。 本发明还提供了制备用于制备药物的组合物，组合物以及使用式I化合物的方法。