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公开(公告)号：EP2763990A1
公开(公告)日：2014-08-13
申请号：EP12761923.7
申请日：2012-08-27
发明人： CHEN, Shaoqing , DE VICENTE FIDALGO, Javier , HAMILTON, Matthew Michael , HERMANN, Johannes Cornelius , KENNEDY-SMITH, Joshua , LI, Hongju , LOVEY, Allen John , LUCAS, Matthew C. , LUK, Kin-Chun Thomas , LYNCH, Stephen M. , O'YANG, Counde , PADILLA, Fernando , SCHOENFELD, Ryan Craig , SIDDURI, Achyutharao , SOTH, Michael , WANG, Ce , WOVKULICH, Peter Michael , ZHANG, Xiaohu
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/5025 , A61P29/00
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量如本文所述定义，其抑制JAK和SYK并可用于治疗自身免疫和炎性疾病。
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公开(公告)号：EP2691399B1
公开(公告)日：2016-07-13
申请号：EP12710724.1
申请日：2012-03-26
发明人： HERMANN, Johannes Cornelius , LOWRIE, JR., Lee Edwin , LUCAS, Matthew C. , LUK, Kin-Chun Thomas , PADILLA, Fernando , WANNER, Jutta , XIE, Wenwei , ZHANG, Xiaohu
IPC分类号： C07D513/04 , A61K31/519 , A61P19/02
CPC分类号： C07D513/04 , A61K45/06
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公开(公告)号：EP2773645A1
公开(公告)日：2014-09-10
申请号：EP12783182.4
申请日：2012-10-29
发明人： HERMANN, Johannes Cornelius , KUGLSTATTER, Andreas , LUCAS, Matthew C. , PADILLA, Fernando , WANNER, Jutta , ZHANG, Xiaohu
IPC分类号： C07D487/04 , A61K31/5025 , A61P29/00 , A61P19/02 , A61P17/06 , A61P3/10 , A61P37/00 , A61P11/06 , A61P25/28 , A61P35/00 , A61P35/02
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/5377 , A61K31/625 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of novel compounds of formula (I): wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式（I）的新化合物的用途：其中所有可变取代基如本文所述定义，其为SYK抑制剂且可用于治疗自身免疫和炎性疾病。
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公开(公告)号：EP2691399A1
公开(公告)日：2014-02-05
申请号：EP12710724.1
申请日：2012-03-26
发明人： HERMANN, Johannes Cornelius , LOWRIE, JR., Lee Edwin , LUCAS, Matthew C. , LUK, Kin-Chun Thomas , PADILLA, Fernando , WANNER, Jutta , XIE, Wenwei , ZHANG, Xiaohu
IPC分类号： C07D513/04 , A61K31/519 , A61P19/02
CPC分类号： C07D513/04 , A61K45/06
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途：其中所有可变取代基如本文所述定义，其为SYK抑制剂且可用于治疗自身免疫疾病和炎性疾病。
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