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公开(公告)号：EP2498780A2
公开(公告)日：2012-09-19
申请号：EP10781468.3
申请日：2010-11-10
IPC分类号： A61K31/52
CPC分类号： A61K31/52 , A61K31/5377 , C07D473/34
摘要： The present invention relates to compounds of Formula (I), wherein R
1 , R
2 , R
3 , A
1 , A
2 , A
3 , A
4 and D have the meaning described herein. The present invention also relates to pharmaceutical compositions comprising such compounds and therapeutic uses against cancer via inhibition of mTOR and PI3K.-
2.发明公开2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS 审中-公开作为丝氨酸/苏氨酸激酶抑制剂的2,4-二胺 - 嘧啶衍生物
公开(公告)号：EP2794605A1
公开(公告)日：2014-10-29
申请号：EP12812254.6
申请日：2012-12-21
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4353 , A61P35/00
CPC分类号： A61K31/519 , A61K31/506 , A61K45/06 , C07D471/04 , C07D487/04
摘要： Compounds having the formula I wherein A, R
1a , R
1b , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , R
a , R
b , X
1 , X
2 , X
3 and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.摘要翻译： 其中A，R 1a，R 1b，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R a，R b，X 1，X 2，X 3和 n如本文所定义是PAK1的抑制剂。 还公开了用于治疗癌症和过度增殖性疾病的组合物和方法。
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公开(公告)号：EP2742046A1
公开(公告)日：2014-06-18
申请号：EP12748670.2
申请日：2012-08-10
发明人： DO, Steven , HU, Huiyong , KOLESNIKOV, Aleksandr , LEE, Wendy , TSUI, Vickie Hsiao-Wei , WANG, Xiaojing , WEN, Zhaoyang
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00 , A61P35/00 , A61P37/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/4995 , A61K31/506 , A61K31/55 , A61K31/551 , A61K45/06 , C07D231/00 , C07D519/00
摘要： Pyrazolo[3,4-c]pyridine compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R
1 and R
2 are as defined herein, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.-
4.发明公开N-7 SUBSTITUTED PURINE AND PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE 有权N7-取代嘌呤和吡唑并嘧啶化合物，组合物及使用方法
公开(公告)号：EP2499143A1
公开(公告)日：2012-09-19
申请号：EP10776992.9
申请日：2010-11-10
IPC分类号： C07D473/34 , C07D487/04 , C07D519/00 , A61K31/52 , A61K31/519 , A61P35/00
CPC分类号： C07D473/34 , C07D487/04 , C07D519/00
摘要： The present invention relates to compounds of Formula (I) wherein R
1 , R
2 , R
3 , A
1 , A
2 , A
3 , A
4 , Y
1 and Y
2 and D have the meaning described herein. The present invention also relates to pharmaceutical compositions comprising such compounds and therapeutic uses thereof.-
公开(公告)号：EP2498780B1
公开(公告)日：2016-09-07
申请号：EP10781468.3
申请日：2010-11-10
IPC分类号： A61K31/52
CPC分类号： A61K31/52 , A61K31/5377 , C07D473/34
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6.发明授权N7-SUBSTITUTED PURINE AND PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE 有权N7-取代嘌呤和吡唑并嘧啶化合物，组合物及使用方法
公开(公告)号：EP2499143B1
公开(公告)日：2016-03-16
申请号：EP10776992.9
申请日：2010-11-10
IPC分类号： C07D473/34 , C07D487/04 , C07D519/00 , A61K31/52 , A61K31/519 , A61P35/00
CPC分类号： C07D473/34 , C07D487/04 , C07D519/00
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公开(公告)号：EP2748159A1
公开(公告)日：2014-07-02
申请号：EP12755816.1
申请日：2012-08-24
IPC分类号： C07D403/14 , A61K31/506 , A61P35/00
CPC分类号： C07D403/14 , A61K31/506 , A61K45/06
摘要： Compounds having the formula I wherein A, Z, R
1a , R
1b , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
9 , R
10, R
a , R
b and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.
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