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1.发明授权
公开(公告)号：EP1984340B1
公开(公告)日：2012-06-27
申请号：EP07726239.2
申请日：2007-01-29
发明人： CONTE, Aurelia , KUEHNE, Holger , LUEBBERS, Thomas , MATTEI, Patrizio , MAUGEAIS, Cyrille , MUELLER, Werner , PFLIEGER, Philippe
IPC分类号： C07D213/82 , C07D231/14 , C07D261/18 , C07D275/02 , C07D333/38 , C07D401/12 , C07D403/12 , C07C237/32 , A61K31/44 , A61P3/00
CPC分类号： C07D213/82 , C07C237/30 , C07C237/32 , C07C255/25 , C07C255/54 , C07C271/28 , C07C309/66 , C07C311/08 , C07C2601/02 , C07C2601/04 , C07C2601/06 , C07D231/14 , C07D261/18 , C07D275/03 , C07D333/38 , C07D401/12 , C07D403/12 , C07F7/0818
摘要： Compounds of formula I processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 式I化合物的制备方法，它们作为药物的用途以及包含它们的药物组合物。
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2.发明公开2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS 有权2,3-二芳基或杂芳基取代的1,1,1-三氟-2-羟基丙基化合物
公开(公告)号：EP2411365A1
公开(公告)日：2012-02-01
申请号：EP10709740.4
申请日：2010-03-23
发明人： HUNZIKER, Daniel , LERNER, Christian , MUELLER, Werner , OBST SANDER, Ulrike , PFLIEGER, Philippe , WALDMEIER, Pius
IPC分类号： C07D213/63 , C07D235/26 , C07D263/58 , C07D265/36 , C07D285/14 , C07D317/46 , C07D317/54 , C07D401/12 , C07D413/12 , C07D455/02 , C07D498/04 , A61K31/536 , A61K31/5415 , C07C255/53 , A61P3/10
CPC分类号： C07D413/10 , C07C255/54 , C07C255/57 , C07D213/63 , C07D235/26 , C07D263/58 , C07D265/36 , C07D285/14 , C07D317/46 , C07D317/54 , C07D317/60 , C07D401/10 , C07D401/12 , C07D403/12 , C07D413/12 , C07D455/02 , C07D498/04
摘要： The present invention relates to compounds of formula (I), wherein R
1a to R
1e , R
2 , R
3 and R
5 are as defined in the description and claims and R
4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically 5 acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.-
3.发明授权TRIALKYLSILYLBENZYLAMINOCARBOXYINDOLES, INDAZOLES AND INDOLINES AND THEIR USE IN TREATING CETP-MEDIATED DISORDERS 有权TRIALKYLSILYLBENZYLAMINOCARBOXYINDOLE，吲唑和吲哚啉及其用于治疗CETP介导的疾病
公开(公告)号：EP1984002B1
公开(公告)日：2010-12-22
申请号：EP07712128.3
申请日：2007-01-29
发明人： CONTE, Aurelia , KUEHNE, Holger , LUEBBERS, Thomas , MATTEI, Patrizio , MAUGEAIS, Cyrille , MUELLER, Werner , PFLIEGER, Philippe
IPC分类号： A61K31/695 , C07F7/08 , A61P9/10
CPC分类号： C07F7/0812
摘要： Compounds of formula (I) their manufacture, pharmaceutical compositions containing them and their use as medicaments in the treatment and /or prophylaxis of diseases mediated by cholesteryl ester transfer protein (CETP).
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4.发明授权2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS 有权2,3-二芳基或杂芳基取代的1,1,1-三氟-2-羟基丙基化合物
公开(公告)号：EP2411365B1
公开(公告)日：2014-03-19
申请号：EP10709740.4
申请日：2010-03-23
发明人： HUNZIKER, Daniel , LERNER, Christian , MUELLER, Werner , OBST SANDER, Ulrike , PFLIEGER, Philippe , WALDMEIER, Pius
IPC分类号： C07D213/63 , C07D235/26 , C07D263/58 , C07D265/36 , C07D285/14 , C07D317/46 , C07D317/54 , C07D401/12 , C07D413/12 , C07D455/02 , C07D498/04 , A61K31/536 , A61K31/5415 , C07C255/53 , A61P3/10 , C07C255/54 , C07D403/12 , C07C255/57 , C07D317/60 , C07D401/10 , C07D413/10
CPC分类号： C07D413/10 , C07C255/54 , C07C255/57 , C07D213/63 , C07D235/26 , C07D263/58 , C07D265/36 , C07D285/14 , C07D317/46 , C07D317/54 , C07D317/60 , C07D401/10 , C07D401/12 , C07D403/12 , C07D413/12 , C07D455/02 , C07D498/04
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公开(公告)号：EP2411361B1
公开(公告)日：2014-06-18
申请号：EP10712038.8
申请日：2010-03-23
发明人： HUNZIKER, Daniel , LERNER, Christian , MUELLER, Werner , OBST SANDER, Ulrike , PFLIEGER, Philippe , WALDMEIER, Pius
IPC分类号： C07D207/34 , C07D213/30 , C07D213/61 , C07D213/64 , C07D215/14 , C07D217/16 , C07D241/12 , C07D241/42 , C07D333/38 , C07D401/12 , C07D413/12 , C07D471/02 , A61K31/381 , A61K31/40 , A61K31/437
CPC分类号： C07D241/12 , C07D207/34 , C07D213/30 , C07D213/61 , C07D213/64 , C07D215/14 , C07D217/16 , C07D241/42 , C07D333/38 , C07D401/12 , C07D413/12 , C07D471/02
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公开(公告)号：EP2411361A1
公开(公告)日：2012-02-01
申请号：EP10712038.8
申请日：2010-03-23
发明人： HUNZIKER, Daniel , LERNER, Christian , MUELLER, Werner , OBST SANDER, Ulrike , PFLIEGER, Philippe , WALDMEIER, Pius
IPC分类号： C07D207/34 , C07D213/30 , C07D213/61 , C07D213/64 , C07D215/14 , C07D217/16 , C07D241/12 , C07D241/42 , C07D333/38 , C07D401/12 , C07D413/12 , C07D471/02 , A61K31/381 , A61K31/40 , A61K31/437
CPC分类号： C07D241/12 , C07D207/34 , C07D213/30 , C07D213/61 , C07D213/64 , C07D215/14 , C07D217/16 , C07D241/42 , C07D333/38 , C07D401/12 , C07D413/12 , C07D471/02
摘要： The present invention relates to compounds of formula I wherein R
la to R
le and R
2 to R
5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.摘要翻译： 本发明涉及式I的化合物及其药学上可接受的盐，其中R 1a至R 1a和R 2至R 5如说明书和权利要求书中所定义。 这些化合物是糖皮质激素受体拮抗剂，可用于治疗和/或预防疾病，例如糖尿病，血脂异常，肥胖症，高血压，心血管疾病，肾上腺失衡或抑郁症。
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公开(公告)号：EP1984340A1
公开(公告)日：2008-10-29
申请号：EP07726239.2
申请日：2007-01-29
发明人： CONTE, Aurelia , KUEHNE, Holger , LUEBBERS, Thomas , MATTEI, Patrizio , MAUGEAIS, Cyrille , MUELLER, Werner , PFLIEGER, Philippe
IPC分类号： C07D213/82 , C07D231/14 , C07D261/18 , C07D275/02 , C07D333/38 , C07D401/12 , C07D403/12 , C07C237/32 , A61K31/44 , A61P3/00
CPC分类号： C07D213/82 , C07C237/30 , C07C237/32 , C07C255/25 , C07C255/54 , C07C271/28 , C07C309/66 , C07C311/08 , C07C2601/02 , C07C2601/04 , C07C2601/06 , C07D231/14 , C07D261/18 , C07D275/03 , C07D333/38 , C07D401/12 , C07D403/12 , C07F7/0818
摘要： Compounds of formula I processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
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8.发明公开TRIALKYLSILYLBENZYLAMINOCARBOXYINDOLES, INDAZOLES AND INDOLINES AND THEIR USE IN TREATING CETP-MEDIATED DISORDERS 有权TRIALKYLSILYLBENZYLAMINOCARBOXYINDOLE，吲唑和吲哚啉及其用于治疗CETP介导的疾病
公开(公告)号：EP1984002A1
公开(公告)日：2008-10-29
申请号：EP07712128.3
申请日：2007-01-29
发明人： CONTE, Aurelia , KUEHNE, Holger , LUEBBERS, Thomas , MATTEI, Patrizio , MAUGEAIS, Cyrille , MUELLER, Werner , PFLIEGER, Philippe
IPC分类号： A61K31/695 , C07F7/08 , A61P9/10
CPC分类号： C07F7/0812
摘要： Compounds of formula (I) their manufacture, pharmaceutical compositions containing them and their use as medicaments in the treatment and /or prophylaxis of diseases mediated by cholesteryl ester transfer protein (CETP).
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