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公开(公告)号：EP2861566A1
公开(公告)日：2015-04-22
申请号：EP13731049.6
申请日：2013-06-10
IPC分类号： C07D249/18 , C07D471/10 , C07D487/10 , C07D205/12 , C07D405/06 , C07D405/12 , C07D413/12 , A61K31/438 , A61P35/00
CPC分类号： C07D471/10 , C07D205/12 , C07D249/18 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/12 , C07D487/10 , C07D519/00
摘要： The invention provides novel compounds having the general formula (I), wherein R
1 , R
2 , Y and W are as described herein, compositions including the compounds and methods of using the compounds.摘要翻译： 其中R 1，R 2，Y和W如本文所述，包括该化合物的组合物和使用该化合物作为自分泌素抑制剂的方法。
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公开(公告)号：EP2491022B1
公开(公告)日：2014-12-31
申请号：EP10765643.1
申请日：2010-10-18
发明人： AEBI, Johannes , BINGGELI, Alfred , GREEN, Luke , HARTMANN, Guido , MAERKI, Hans P. , MATTEI, Patrizio
IPC分类号： C07D241/10 , C07D243/08 , C07D401/06 , C07D403/06 , C07D491/044 , C07D498/04 , C07D401/14 , A61K31/551 , A61K31/497 , A61K31/503 , A61P9/10
CPC分类号： C07D401/06 , C07D241/10 , C07D243/08 , C07D401/14 , C07D403/06 , C07D491/044 , C07D498/04
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3.发明公开1-CYCLOALKYL- OR 1-HETEROCYCLYL-HYDROXYIMINO-3-PHENYL-PROPANES 审中-公开1-环烷基-2-甲基-1-环己基 - 羟基亚氨基-3-苯基丙酸
公开(公告)号：EP2771313A1
公开(公告)日：2014-09-03
申请号：EP12775028.9
申请日：2012-10-23
发明人： DEHMLOW, Henrietta , MARTIN, Rainer E. , MATTEI, Patrizio , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07C251/42 , C07C317/32 , C07D211/40 , C07D309/06 , C07D335/02 , A61K31/15 , A61K31/35 , A61K31/382 , A61K31/445 , A61K31/45 , A61P3/10
CPC分类号： C07D401/10 , C07C251/42 , C07C317/32 , C07C2601/04 , C07C2601/14 , C07D211/28 , C07D211/76 , C07D309/04 , C07D335/02
摘要： This invention relates to novel 1-cycloalkyl- or l-heterocyclyl-hydroxyimino-3-phen propanes of the formula wherein R
1 to R
7 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may therefore be useful as medicaments for the treatment of diseases such as type II diabetes.摘要翻译： 本发明涉及下式的新的1-环烷基 - 或1-杂环基 - 肟基-3-苯基 - 丙烷，其中R 1至R 7如说明书和权利要求书中所定义，以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂，因此可用作治疗诸如II型糖尿病的疾病的药物。
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公开(公告)号：EP2486042B1
公开(公告)日：2014-01-22
申请号：EP10766012.8
申请日：2010-10-05
发明人： AEBI, Johannes , BINGGELI, Alfred , GREEN, Luke , HARTMANN, Guido , MAERKI, Hans P. , MATTEI, Patrizio
IPC分类号： C07D487/04 , C07D491/04 , A61K31/52 , A61P9/10 , A61P29/00
CPC分类号： C07D417/14 , C07D417/04 , C07D487/04 , C07D491/048 , C07D498/04
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5.发明公开NOVEL HETEROBICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF LIVER CARNITINE PALMITOYL TRANSFERASE 有权新杂衍生物肝脏肉碱棕榈酰TRANSFERASEHEMMER
公开(公告)号：EP1926711A1
公开(公告)日：2008-06-04
申请号：EP06793207.9
申请日：2006-09-05
发明人： ACKERMANN, Jean , BLEICHER, Konrad , CECCARELLI, Simona Maria , CHOMIENNE, Odile , MATTEI, Patrizio , SCHULZ-GASCH, Tanja
IPC分类号： C07D209/10 , C07D403/12 , C07D413/12 , C07D215/58 , C07D223/16
CPC分类号： C07D223/16 , C07D209/10 , C07D215/58 , C07D403/12 , C07D413/12
摘要： The invention is concerned with novel heterobicyclic derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPTl and can be used as medicaments.
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公开(公告)号：EP1480976A1
公开(公告)日：2004-12-01
申请号：EP03742945.3
申请日：2003-02-19
发明人： MATTEI, Patrizio , NEIDHART, Werner , NETTEKOVEN, Matthias, Heinrich , PFLIEGER, Philippe , TAYLOR, Sven
IPC分类号： C07D417/06 , C07D277/42 , C07D417/12 , C07D417/14 , A61K31/425
CPC分类号： C07D417/06 , C07D277/42
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5, n, m and A have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
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7.发明公开NEW OCTAHYDRO-PYRROLO[3,4-C]-PYRROLE DERIVATIVES AND ANALOGS THEREOF AS AUTOTAXIN INHIBITORS 审中-公开NEER OCAHYDRO-PYRROLO [3,4-C] -PYRROL-DERIVATE UND ANALOGA DAVON ALS AUTOTAXIN-INHIBITOREN
公开(公告)号：EP2970256A1
公开(公告)日：2016-01-20
申请号：EP14708891.8
申请日：2014-03-11
发明人： HERT, Jérôme , HUNZIKER, Daniel , MATTEI, Patrizio , MAUSER, Harald , TANG, Guozhi , WANG, Lisha
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/407 , A61K31/5517 , A61P29/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R 1，Y，A，W，R 2，m，n，p和q如本文所述，包括该化合物的组合物和使用该化合物的方法。
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8.发明公开NEW BICYCLIC DERIVATIVES 审中-公开六氢[3,4-c]吡咯衍生物和相关化合物作为自分泌运动因子（ATX）抑制剂和ASLYSOPHOSPHATINSÄURE（LPA）的生产用于治疗例如抑制剂 肾脏疾病
公开(公告)号：EP2900669A1
公开(公告)日：2015-08-05
申请号：EP13766056.9
申请日：2013-09-23
发明人： HERT, Jérôme , HUNZIKER, Daniel , MATTEI, Patrizio , MAUSER, Harald , TANG, Guozhi , WANG, Lisha
IPC分类号： C07D487/04 , A61K31/407 , A61P13/12 , A61P1/16 , A61P25/00 , A61P37/06
CPC分类号： C07D471/04 , C07D403/12 , C07D413/12 , C07D487/04 , C07D519/00
摘要： The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： worin R1，Y，A，W，R 2，M，N，p和q是如描述于，组合物，包括的化合物和使用所述化合物的方法。
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9.发明授权
公开(公告)号：EP2007726B1
公开(公告)日：2011-03-02
申请号：EP07712127.5
申请日：2007-01-29
发明人： FAEH, Christoph , KUEHNE, Holger , LUEBBERS, Thomas , MATTEI, Patrizio , MAUGEAIS, Cyrille , PFLIEGER, Philippe
IPC分类号： C07D213/40
CPC分类号： C07D405/12 , C07D213/40 , C07D213/82 , C07D277/28 , C07D333/58 , C07D333/60 , C07D401/12 , C07D409/12 , C07D417/12
摘要： Compounds of formula (I) processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
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公开(公告)号：EP1984364A1
公开(公告)日：2008-10-29
申请号：EP07712129.1
申请日：2007-01-29
发明人： KUEHNE, Holger , LUEBBERS, Thomas , MATTEI, Patrizio , MAUGEAIS, Cyrille , PFLIEGER, Philippe , SCALONE, Michelangelo
IPC分类号： C07D471/04 , A61K31/437 , A61P31/18
CPC分类号： C07D471/04
摘要： Compounds of formula (I), processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
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