公开(公告)号：EP3215141A2

公开(公告)日：2017-09-13

申请号：EP15856241.3

申请日：2015-11-05

申请人： Flexus Biosciences, Inc.

发明人： BECK, Hilary Plake ,  JAEN, Juan Carlos ,  OSIPOV, Maksim ,  POWERS, Jay Patrick ,  REILLY, Maureen Kay ,  SHUNATONA, Hunter Paul ,  WALKER, James Ross ,  ZIBINSKY, Mikhail ,  BALOG, James Aaron ,  WILLIAMS, David K. ,  GUO, Weiwei

IPC分类号： A61K31/16 ,  C07C13/02 ,  C07C13/16

CPC分类号： A61K31/195 ,  A61K31/167 ,  A61K31/426 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/55511 ,  A61P35/00 ,  C07C233/15 ,  C07C233/29 ,  C07C233/66 ,  C07C235/26 ,  C07C235/36 ,  C07C235/38 ,  C07C237/20 ,  C07C237/22 ,  C07C255/57 ,  C07C255/60 ,  C07C317/40 ,  C07C317/44 ,  C07C321/28 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D207/27 ,  C07D213/56 ,  C07D213/75 ,  C07D231/12 ,  C07D239/42 ,  C07D277/30 ,  C07D295/15 ,  C07D295/155 ,  C07D309/04 ,  C07D309/06 ,  C07D317/46 ,  Y02A50/41 ,  Y02A50/412 ,  A61K2300/00

摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3- dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune -related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

摘要翻译： 本文描述了调节氧化还原酶吲哚胺2,3-双加氧酶的化合物和含有该化合物的组合物。 还提供了此类化合物和组合物用于治疗和/或预防由吲哚胺2,3-双加氧酶介导的各种疾病，病症和病症（包括癌症和免疫相关病症）的用途。

公开(公告)号：EP3854394A1

公开(公告)日：2021-07-28

申请号：EP20213702.2

申请日：2015-11-05

申请人： Flexus Biosciences, Inc.

发明人： BECK, Hilary Plake ,  JAEN, Juan Carlos ,  OSIPOV, Maksim ,  POWERS, Jay Patrick ,  REILLY, Maureen Kay ,  SHUNATONA, Hunter Paul ,  WALKER, James Ross ,  ZIBINSKY, Mikhail ,  BALOG, James Aaron ,  WILLIAMS, David K ,  MARKWALDER, Jay A ,  CHERNEY, Emily Charlotte ,  SHAN, Weifang ,  HUANG, Audris

IPC分类号： A61K31/4375 ,  A61K31/4709 ,  A61K31/496 ,  C07D215/14 ,  C07D231/56 ,  C07D215/233 ,  C07D471/04 ,  C07D239/74 ,  C07D217/04 ,  C07D405/12 ,  C07D401/12 ,  C07D401/14 ,  C07D487/04

摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3- dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：EP3215153A1

公开(公告)日：2017-09-13

申请号：EP15857812.0

申请日：2015-11-05

申请人： Flexus Biosciences, Inc.

发明人： BECK, Hilary Plake ,  JAEN, Juan Carlos ,  OSIPOV, Maksim ,  POWERS, Jay Patrick ,  REILLY, Maureen Kay ,  SHUNATONA, Hunter Paul ,  WALKER, James Ross ,  ZIBINSKY, Mikhail ,  BALOG, James Aaron ,  WILLIAMS, David K ,  MARKWALDER, Jay A ,  CHERNEY, Emily Charlotte ,  SHAN, Weifang ,  HUANG, Audris

IPC分类号： A61K31/4375 ,  A61K31/4709 ,  A61K31/496

CPC分类号： C07D487/04 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K45/06 ,  C07D215/06 ,  C07D215/14 ,  C07D215/233 ,  C07D217/04 ,  C07D231/56 ,  C07D239/74 ,  C07D401/12 ,  C07D401/14 ,  C07D405/08 ,  C07D405/12 ,  C07D417/08 ,  C07D417/12 ,  C07D471/04

摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：EP3215142A2

公开(公告)日：2017-09-13

申请号：EP15857810.4

申请日：2015-11-05

申请人： Flexus Biosciences, Inc.

发明人： BECK, Hilary Plake ,  JAEN, Juan Carlos ,  OSIPOV, Maksim ,  POWERS, Jay Patrick ,  REILLY, Maureen Kay ,  SHUNATONA, Hunter Paul ,  WALKER, James Ross ,  ZIBINSKY, Mikhail ,  BALOG, James Aaron ,  WILLIAMS, David K. ,  MARKWALDER, Jay A. ,  SEITZ, Steven P. ,  CHERNEY, Emily Charlotte ,  ZHANG, Liping ,  SHAN, Weifang ,  GUO, Weiwei ,  HUANG, Audris

IPC分类号： A61K31/16 ,  C07C13/02 ,  C07C13/16

CPC分类号： A61K31/166 ,  A61K31/00 ,  A61K31/136 ,  A61K31/277 ,  A61K31/4412 ,  A61K31/445 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07C211/45 ,  C07C217/80 ,  C07C233/10 ,  C07C233/59 ,  C07C233/60 ,  C07C233/65 ,  C07C233/74 ,  C07C255/50 ,  C07C255/58 ,  C07C275/30 ,  C07C2601/14 ,  C07D211/08 ,  C07D213/68 ,  C07D215/04 ,  C07D215/233 ,  C07D487/04

摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

摘要翻译： 本文描述了调节氧化还原酶吲哚胺2,3-双加氧酶的化合物和含有该化合物的组合物。 还提供了此类化合物和组合物用于治疗和/或预防由吲哚胺2,3-双加氧酶介导的多种疾病，病症和病症（包括癌症和免疫相关病症）的用途。