公开(公告)号：EP4433055A1

公开(公告)日：2024-09-25

申请号：EP22894019.3

申请日：2022-11-18

申请人： Race Oncology Ltd.

发明人： TILLETT, Daniel ,  NGO, Doan Thi Minh ,  SVERDLOV, Aaron Leonid

IPC分类号： A61K31/473 ,  A61K31/704 ,  A61K38/05 ,  A61K38/07 ,  A61K39/395 ,  A61P9/00 ,  A61P35/00 ,  A61P39/00 ,  C07K16/32

CPC分类号： A61K31/704 ,  A61P9/00 ,  A61P35/00 ,  A61P39/00 ,  C07K16/32 ,  A61K39/39558 ,  A61K31/4168 ,  A61K31/136

公开(公告)号：EP3191138B1

公开(公告)日：2024-05-29

申请号：EP15840525.8

申请日：2015-09-09

IPC分类号： A61K9/00 ,  A61K9/51 ,  A61K31/136 ,  A61K31/4745 ,  A61K31/55 ,  A61K31/704 ,  A61P35/00

CPC分类号： A61K9/0019 ,  A61K9/5123 ,  A61K31/136 ,  A61K31/4745 ,  A61K31/55 ,  A61K31/704 ,  A61P35/00

公开(公告)号：EP3362057A1

公开(公告)日：2018-08-22

申请号：EP16787982.4

申请日：2016-10-14

申请人： Agios Pharmaceuticals, Inc.

发明人： AGRESTA, Samuel, V.

IPC分类号： A61K31/136 ,  A61K31/53 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61P35/02

CPC分类号： A61K31/53 ,  A61K31/136 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61K2300/00 ,  A61P35/02

摘要： Provided are methods and compositions for treating AML in patients carrying an IDH2 mutation using a combination of an inhibitor of a mutant IDH2 enzyme and an AML induction and consolidation therapy.

公开(公告)号：EP3345545A1

公开(公告)日：2018-07-11

申请号：EP18150647.8

申请日：2012-04-04

申请人： The Regents of the University of California

发明人： AKHTARI, Massoud

IPC分类号： A61B5/055 ,  A61K49/18

CPC分类号： A61K49/10 ,  A61K9/0019 ,  A61K31/132 ,  A61K31/133 ,  A61K31/136 ,  A61K31/145 ,  A61K31/167 ,  A61K31/277 ,  A61K31/427 ,  A61K31/428 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/472 ,  A61K31/4745 ,  A61K49/1833

摘要： The present disclosure provides functionalized magnetic nanoparticles (MNPs) comprising a functional group that binds to β-amyloid deposits and/or neurofibrillary tangles. The present disclosure provides compositions comprising the functionalized MNPs, and methods of using the functionalized MNPs in imaging β-amyloid deposits and neurofibrillary tangles.

公开(公告)号：EP3110396B1

公开(公告)日：2018-07-04

申请号：EP15712204.5

申请日：2015-02-27

申请人： The Procter & Gamble Company

发明人： LIN, Yakang ,  SREEKRISHNA, Koti ,  NEWLON, Jason, William ,  FINDLEY, Molly, Christine

IPC分类号： A61K8/84 ,  A61K9/00 ,  A61K31/00

CPC分类号： A61K47/34 ,  A61K8/84 ,  A61K9/0095 ,  A61K9/08 ,  A61K31/09 ,  A61K31/135 ,  A61K31/136 ,  A61K31/167 ,  A61K31/485 ,  A61K2300/00

摘要： A liquid medication with reduced bitterness containing a drug active and polyquaternium-2, polyquaternium-17, and/or polyquaternium-18.

公开(公告)号：EP3180010A4

公开(公告)日：2018-06-20

申请号：EP15832175

申请日：2015-08-12

申请人： EPIZYME INC ,  CELGENE CORP

发明人： KLAUS CHRISTINE ,  RAIMONDI MARIA ALEJANDRA ,  DAIGLE SCOTT RICHARD ,  POLLOCK ROY MACFARLANE ,  CHOPRA VIVEK

IPC分类号： A61K31/7076 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/708 ,  A61K45/06 ,  A61P35/00

CPC分类号： A61K31/7064 ,  A61K31/135 ,  A61K31/136 ,  A61K31/4045 ,  A61K31/4745 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/704 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/7076 ,  A61K45/06 ,  A61P35/00 ,  A61K2300/00

摘要： The disclosure relates to combinations comprising inhibitors of human histone methyltransferase DOT1L and one or more therapeutic agents, particularly anticancer agents, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.

公开(公告)号：EP2410987B1

公开(公告)日：2018-05-16

申请号：EP10710144.6

申请日：2010-03-22

申请人： Ambit Biosciences Corporation

发明人： ARMSTRONG, Robert, C. ,  BELLI, Barbara, A.

IPC分类号： A61K9/08 ,  A61K31/17 ,  A61K31/365 ,  A61K31/4188 ,  A61K31/42 ,  A61K31/428 ,  A61K31/429 ,  A61K31/52 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/661 ,  A61K31/704 ,  A61K31/7048 ,  A61K45/06

CPC分类号： A61K31/5377 ,  A61K9/0019 ,  A61K31/136 ,  A61K31/17 ,  A61K31/365 ,  A61K31/4188 ,  A61K31/42 ,  A61K31/428 ,  A61K31/429 ,  A61K31/52 ,  A61K31/53 ,  A61K31/661 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61K45/06 ,  A61K2300/00

摘要： Provided herein are methods of treating a proliferative disease in a subject, comprising administering to the subject a therapeutically effective amount of AC220 and a nucleoside analog, a topoisomerase inhibitor or an anthracycline, or a combination thereof.

公开(公告)号：EP2877166B1

公开(公告)日：2018-02-28

申请号：EP13822655.0

申请日：2013-07-26

申请人： Biogen MA Inc.

发明人： GUCKIAN, Kevin ,  KUMARAVEL, Gnanasambandam ,  MA, Bin ,  MI, Sha ,  PENG, Hairuo ,  SHAO, Zhaohui ,  SUN, Lihong ,  TAVERAS, Arthur ,  WANG, Deping ,  XIN, Zhili ,  ZHANG, Lei

IPC分类号： C07D217/22 ,  C07D221/22 ,  C07D223/06 ,  C07D471/08 ,  C07D209/52 ,  C07D211/34 ,  C07D295/096 ,  C07D211/62 ,  C07C255/59 ,  C07C229/46 ,  C07C229/48 ,  A61K31/015 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/136 ,  A61K31/196 ,  A61P19/02 ,  A61P37/00 ,  A61P9/10 ,  A61P11/00

CPC分类号： C07D451/02 ,  A61K31/136 ,  A61K31/196 ,  A61K31/439 ,  A61K31/445 ,  A61K31/46 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/5375 ,  A61K31/55 ,  A61K45/06 ,  C07B2200/07 ,  C07C217/22 ,  C07C229/46 ,  C07C229/48 ,  C07C255/59 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07D209/52 ,  C07D211/34 ,  C07D211/62 ,  C07D217/22 ,  C07D221/22 ,  C07D223/06 ,  C07D295/096 ,  C07D401/06 ,  C07D471/08 ,  Y02A50/401

摘要： Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.

公开(公告)号：EP3265103A1

公开(公告)日：2018-01-10

申请号：EP16759492.8

申请日：2016-03-03

申请人： Yee, Richard W. ,  Hughes, Kenneth

发明人： Yee, Richard W. ,  Hughes, Kenneth

IPC分类号： A61K31/74 ,  A61K47/48

CPC分类号： A61K31/585 ,  A61K9/0048 ,  A61K31/136 ,  A61K31/145 ,  A61K45/06 ,  A61K47/10 ,  A61K47/38 ,  A61K2300/00

摘要： The compositions and methods disclosed herein provide for treatments of ocular disorders of the eye, such as ocular surface diseases as well as those associated with inflammation of internal cells and cell layers of the eye. The methods disclosed herein describe methods for treating ocular disorders, particularly dry eye disorders, comprising topically administering to an ocular region of a subject a composition comprising a pharmaceutically effective amount of at least one aldosterone antagonist or salt thereof and a pharmaceutically acceptable carrier. Included is a method for treating dry eye comprising topically administering to an ocular region of a subject a composition comprising spironolactone and hydroxypropyl methylcellulose; and reducing or preventing one or more symptoms or causes of dry eye.

公开(公告)号：EP3215142A2

公开(公告)日：2017-09-13

申请号：EP15857810.4

申请日：2015-11-05

申请人： Flexus Biosciences, Inc.

发明人： BECK, Hilary Plake ,  JAEN, Juan Carlos ,  OSIPOV, Maksim ,  POWERS, Jay Patrick ,  REILLY, Maureen Kay ,  SHUNATONA, Hunter Paul ,  WALKER, James Ross ,  ZIBINSKY, Mikhail ,  BALOG, James Aaron ,  WILLIAMS, David K. ,  MARKWALDER, Jay A. ,  SEITZ, Steven P. ,  CHERNEY, Emily Charlotte ,  ZHANG, Liping ,  SHAN, Weifang ,  GUO, Weiwei ,  HUANG, Audris

IPC分类号： A61K31/16 ,  C07C13/02 ,  C07C13/16

CPC分类号： A61K31/166 ,  A61K31/00 ,  A61K31/136 ,  A61K31/277 ,  A61K31/4412 ,  A61K31/445 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07C211/45 ,  C07C217/80 ,  C07C233/10 ,  C07C233/59 ,  C07C233/60 ,  C07C233/65 ,  C07C233/74 ,  C07C255/50 ,  C07C255/58 ,  C07C275/30 ,  C07C2601/14 ,  C07D211/08 ,  C07D213/68 ,  C07D215/04 ,  C07D215/233 ,  C07D487/04

摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

摘要翻译： 本文描述了调节氧化还原酶吲哚胺2,3-双加氧酶的化合物和含有该化合物的组合物。 还提供了此类化合物和组合物用于治疗和/或预防由吲哚胺2,3-双加氧酶介导的多种疾病，病症和病症（包括癌症和免疫相关病症）的用途。