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公开(公告)号：EP3319739A1
公开(公告)日：2018-05-16
申请号：EP16753490.8
申请日：2016-07-09
发明人： LIPKENS, Bart , PRESZ, Walter, M., Jr. , CHITALE, Kedar , KENNEDY, Thomas, J., III , GILMANSHIN, Rudolf , MEALEY, Dane , DUTRA, Brian , SOKOLOWSKI, David
CPC分类号： B06B1/0238 , B01D21/0009 , B01D21/283 , B06B1/0644 , B06B3/04 , C12M47/02 , H03H9/17
摘要： An acoustophoretic device is disclosed. The acoustophoretic device includes an acoustic chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer includes a piezoelectric material driven by a voltage signal to create a multi-dimensional acoustic standing wave in the acoustic chamber emanating from a non-planar face of the piezoelectric material. A method for separating a second fluid or a particulate from a host fluid is also disclosed. The method includes flowing the mixture through an acoustophoretic device. A voltage signal is sent to drive the ultrasonic transducer to create the multi-dimensional acoustic standing wave in the acoustic chamber such that the second fluid or particulate is continuously trapped in the standing wave, and then agglomerates, aggregates, clumps, or coalesces together, and subsequently rises or settles out of the host fluid due to buoyancy or gravity forces, and exits the acoustic chamber.
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公开(公告)号：EP3529347A1
公开(公告)日：2019-08-28
申请号：EP17804325.3
申请日：2017-10-19
IPC分类号： C12M1/00 , G01N33/543
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公开(公告)号：EP3762482A1
公开(公告)日：2021-01-13
申请号：EP19764743.1
申请日：2019-03-08
发明人： LIPKENS, Bart , TOSTOES, Rui , DUTRA, Brian , GILMANSHIN, Rudolf , DIONNE, Jason , PRESZ, Walter, M., Jr. , ROSS-JOHNSRUD, Benjamin , GHOSHAL, Goutam , CHITALE, Kedar
IPC分类号： C12N5/0783 , C12N5/00 , C12N13/00 , C12M1/00
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公开(公告)号：EP3259596A1
公开(公告)日：2017-12-27
申请号：EP16707321.2
申请日：2016-02-16
发明人： GILMANSHIN, Rudolf , LIPKENS, Bart
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： C07K1/045 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/12 , B01L2400/0436 , C07K16/00 , C12P19/34 , G01N1/31 , G01N15/1459 , G01N33/54313 , G01N2001/4094 , G01N2015/1006
摘要： Described herein are microreactors and methods of modifying support particles using acoustic standing waves. A liquid medium containing suspended support particles is flowed along a flow path through a channel, and an acoustic standing wave is applied to the channel to hold the suspended particles at a point in the channel. The held particles are then subjected to one or more reactions by flowing biochemical reactants through the channel. Unbound biological reactant is optionally washed from the channel. The reacted support particles can be released from the acoustic standing wave for further processing using, for example, flow cytometry or fluorescence microscopy.
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公开(公告)号：EP3481361A1
公开(公告)日：2019-05-15
申请号：EP17723852.4
申请日：2017-05-03
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