-
1.发明公开DRUG TARGET ISOGENES: POLYMORPHISMS IN THE 5-HYDROXYTRYPTAMINE RECEPTOR 1A GENE 审中-公开药物目的等基因：多态性5-羟色胺1A受体基因
公开(公告)号：EP1208112A1
公开(公告)日：2002-05-29
申请号：EP00962018.8
申请日：2000-08-01
CPC分类号： C07K14/70571 , A61K38/00
摘要： Polynucleotides comprising one or more of 3 novel single nucleotide polymorphisms in the human 5-hydroxytryptamine receptor 1A gene (HTR1A) gene are described. Compositions and methods for detecting one or more of these polymorphisms are also disclosed. In addition, various genotypes and haplotypes for HTR1A gene that exist in the population are described.
-
2.发明公开NTRK1 GENETIC MARKERS ASSOCIATED WITH PROGRESSION OF ALZHEIMER’S DISEASE 审中-公开与阿尔茨海默氏症相关的遗传标记NTRK1的进展
公开(公告)号：EP1709058A2
公开(公告)日：2006-10-11
申请号：EP04811574.5
申请日：2004-11-22
发明人： AERSSENS, Jeroen , ATHANASIOU, Maria , BRAIN, Carlos , COHEN, Nadine , DAIN, Bradley , DENTON, R., Rex , JUDSON, Richard, S. , OZDEMIR, Vural , REED, Carol, R.
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要： Haplotypes in the NTRK1 gene associated with progression of Alzheimer’s Disease are disclosed. Compositions and methods for detecting these NTRK1 haplotypes are disclosed.
-
3.发明公开
公开(公告)号：EP1646729A2
公开(公告)日：2006-04-19
申请号：EP04778129.9
申请日：2004-07-12
发明人： AERSSENS, Jeroen , ATHANASIOU, Maria , BRAIN, Carlos , COHEN, Nadine , DAIN, Bradley , DENTON, R., Rex , JUDSON, Richard, S. , OZDEMIR, Vural , REED, Carol, R.
IPC分类号： C12Q1/68 , C07D491/10 , A61K31/554
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： Haplotypes in the CHRNA2 gene associated with cognitive response to galantamine treatment are disclosed. Compositions and methods for detecting and using these CHRNA2 hyplotypes in a variety of clinical applications are disclosed. Such applications include articles of a manufacture comprising galantamine or derivatives thereof that are approved for treating patients having one of these CHRNA2 haplotypes, methods and kits for predicting the response of an individual to galantamine based upon his/her haplotype profile, and methods for treating Alzheimer’s patients based upon their haplotype profile.
-
4.发明公开NTRK1 GENETIC MARKERS ASSOCIATED WITH AGE OF ONSET OF ALZHEIMER'S DISEASE 审中-公开与年龄阿尔茨海默病相关的遗传标记NTRK1爆发
公开(公告)号：EP1678328A2
公开(公告)日：2006-07-12
申请号：EP04794919.3
申请日：2004-10-14
发明人： AERSSENS, Jeroen , ATHANASIOU, Maria , BRAIN, Carlos , COHEN, Nadine , DAIN, Bradley , DENTON, R., Rex , JUDSON, Richard, S. , OZDEMIR, Vural , REED, Carol, R.
CPC分类号： G01N33/6896 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要： Haplotypes in the NTRK1 gene associated with age of onset of Alzheimer’s Disease are disclosed. Compositions and methods for detecting and using these NTRK1 haplotypes in a variety of clinical applications are disclosed. Such applications include articles of manufacture comprising compounds effective in delaying the age of onset of AD in individuals at risk for developing AD and having one of these NTRK1 haplotypes, methods and kits for predicting the age of onset of AD in an individual at risk for developing AD based upon his/her haplotype profile, and methods for delaying the age of onset of AD in individuals at risk for developing AD based upon their haplotype profile.
-
5.发明公开DRUG TARGET ISOGENES: POLYMORPHISMS IN THE IMMUNOGLOBULIN E RECEPTOR I ALPHA SUBUNIT GENE 审中-公开等基因中药宗旨：免疫球蛋白E受体Iα亚基的基因多态性
公开(公告)号：EP1208194A2
公开(公告)日：2002-05-29
申请号：EP00955333.0
申请日：2000-08-02
发明人： CHEW, Anne , DENTON, R., Rex , DUDA, Amy , KLIEM, Stefanie, E. , LANZ, Elizabeth, M. , NANDABALAN, Krishnan , STEPHENS, Joel, Claiborne
CPC分类号： C07K14/70535 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： Polynucleotides comprising one or more of 22 novel single nucleotide polymorphisms in the human Immunoglobulin E Receptor I Alpha Subunit (IGERA) gene are described. Compositions and methods for detecting one or more of these polymorphisms are also disclosed. In addition, various genotypes and haplotypes for IGERA gene that exist in the population are described.
-
-
-
-
搜索结果
5 条记录 (耗时 0.011 秒)
