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1.发明公开NTRK1 GENETIC MARKERS ASSOCIATED WITH PROGRESSION OF ALZHEIMER’S DISEASE 审中-公开与阿尔茨海默氏症相关的遗传标记NTRK1的进展
公开(公告)号：EP1709058A2
公开(公告)日：2006-10-11
申请号：EP04811574.5
申请日：2004-11-22
发明人： AERSSENS, Jeroen , ATHANASIOU, Maria , BRAIN, Carlos , COHEN, Nadine , DAIN, Bradley , DENTON, R., Rex , JUDSON, Richard, S. , OZDEMIR, Vural , REED, Carol, R.
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要： Haplotypes in the NTRK1 gene associated with progression of Alzheimer’s Disease are disclosed. Compositions and methods for detecting these NTRK1 haplotypes are disclosed.
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2.发明公开
公开(公告)号：EP1646729A2
公开(公告)日：2006-04-19
申请号：EP04778129.9
申请日：2004-07-12
发明人： AERSSENS, Jeroen , ATHANASIOU, Maria , BRAIN, Carlos , COHEN, Nadine , DAIN, Bradley , DENTON, R., Rex , JUDSON, Richard, S. , OZDEMIR, Vural , REED, Carol, R.
IPC分类号： C12Q1/68 , C07D491/10 , A61K31/554
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： Haplotypes in the CHRNA2 gene associated with cognitive response to galantamine treatment are disclosed. Compositions and methods for detecting and using these CHRNA2 hyplotypes in a variety of clinical applications are disclosed. Such applications include articles of a manufacture comprising galantamine or derivatives thereof that are approved for treating patients having one of these CHRNA2 haplotypes, methods and kits for predicting the response of an individual to galantamine based upon his/her haplotype profile, and methods for treating Alzheimer’s patients based upon their haplotype profile.
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3.发明公开APOE GENETIC MARKERS ASSOCIATED WITH AGE OF ONSET OF ALZHEIMER'S DISEASE 审中-公开与年龄相关Alzheimer病APOE基因标志首次亮相
公开(公告)号：EP1743036A2
公开(公告)日：2007-01-17
申请号：EP05705750.7
申请日：2005-01-14
发明人： AERSSENS, Jeroen , ATHANASIOU, Maria , BRAIN, Carlos , COHEN, Nadine , DAIN, Bradley , DENTON, R. Rex , JUDSON, Richard S. , OZDEMIR, Vural , REED, Carol R.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要： Haplotypes in the APOE gene associated with age of onset of Alzheimer’s Disease are disclosed. Compositions and methods for detecting and using these APOE haplotypes in a variety of clinical applications are disclosed. Such applications include articles of manufacture comprising compounds effective in delaying the age of onset of AD in individuals at risk for developing AD and having one of these APOE haplotypes, methods and kits for predicting the age of onset of AD in an individual at risk for developing AD based upon his/her haplotype profile, and methods for delaying the age of onset of AD in individuals at risk for developing AD based upon their haplotype profile.
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4.发明公开NTRK1 GENETIC MARKERS ASSOCIATED WITH AGE OF ONSET OF ALZHEIMER'S DISEASE 审中-公开与年龄阿尔茨海默病相关的遗传标记NTRK1爆发
公开(公告)号：EP1678328A2
公开(公告)日：2006-07-12
申请号：EP04794919.3
申请日：2004-10-14
发明人： AERSSENS, Jeroen , ATHANASIOU, Maria , BRAIN, Carlos , COHEN, Nadine , DAIN, Bradley , DENTON, R., Rex , JUDSON, Richard, S. , OZDEMIR, Vural , REED, Carol, R.
CPC分类号： G01N33/6896 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要： Haplotypes in the NTRK1 gene associated with age of onset of Alzheimer’s Disease are disclosed. Compositions and methods for detecting and using these NTRK1 haplotypes in a variety of clinical applications are disclosed. Such applications include articles of manufacture comprising compounds effective in delaying the age of onset of AD in individuals at risk for developing AD and having one of these NTRK1 haplotypes, methods and kits for predicting the age of onset of AD in an individual at risk for developing AD based upon his/her haplotype profile, and methods for delaying the age of onset of AD in individuals at risk for developing AD based upon their haplotype profile.
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