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公开(公告)号：EP4155415A1
公开(公告)日：2023-03-29
申请号：EP22191450.0
申请日：2017-02-27
发明人： BOURGON, Richard , FABRIZIO, David , FINE, Gregg , FRAMPTON, Garrett, M. , HEGDE, Priti , MARIATHASAN, Sanjeev , STEPHENS, Philip J. , SUN, James, Xin , YELENSKY, Roman
IPC分类号： C12Q1/68
摘要： The present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, bladder cancer. The invention provides methods of treating bladder cancer, methods of determining whether a patient suffering from bladder cancer is likely to respond to treatment comprising a PD-L1 axis binding antagonist, methods of predicting responsiveness of a patient suffering bladder cancer to treatment comprising a PD-L1 axis binding antagonist, and methods of selecting a therapy for a patient suffering from bladder cancer, based on somatic mutation levels of genes of the invention (e.g., somatic mutation levels in a tumor sample obtained from the patient.
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公开(公告)号：EP3523451A1
公开(公告)日：2019-08-14
申请号：EP17797468.0
申请日：2017-10-06
发明人： SHAMES, David , FABRIZIO, David , FRAMPTON, Garrett, M. , HEGDE, Priti , KOWANETZ, Marcin , STEPHENS, Philip, J. , SUN, James, Xin , YELENSKY, Roman , ZOU, Wei
IPC分类号： C12Q1/68 , A61K39/395 , A61P35/00 , C07K16/28
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公开(公告)号：EP3423828A1
公开(公告)日：2019-01-09
申请号：EP17760558.1
申请日：2017-02-27
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公开(公告)号：EP3423596A1
公开(公告)日：2019-01-09
申请号：EP17709892.8
申请日：2017-02-27
发明人： BOURGON, Richard , FABRIZIO, David , FINE, Gregg , FRAMPTON, Garrett, M. , HEGDE, Priti , MARIATHASAN, Sanjeev , STEPHENS, Philip J. , SUN, James, Xin , YELENSKY, Roman
IPC分类号： C12Q1/68
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公开(公告)号：EP3423488A1
公开(公告)日：2019-01-09
申请号：EP17760555.7
申请日：2017-02-27
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