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    NUCLEIC ACID INDEXING TECHNIQUES
    2.
    发明公开
    NUCLEIC ACID INDEXING TECHNIQUES 审中-公开

    公开(公告)号：EP4289996A3

    公开(公告)日：2024-01-17

    申请号：EP23205539.2

    申请日：2018-11-05

    申请人： Illumina Inc.

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： G16B35/10 ,  C12Q1/6806 ,  C12Q1/6869 ,  C40B40/06

    摘要： Presented herein are techniques for indexing of nucleic acid, e.g., for use in conjunction with sequencing. The techniques include generating indexed nucleic acid fragments from an individual sample, whereby the index sequence incorporated into each index site of the nucleic acid fragment is selected from a plurality of distinguishable of index sequences and such that the population of generated nucleic acid fragments represents each index sequence from the plurality. In this manner, the generated indexed nucleic acid fragments from a single sample are indexed with a diverse mix of index sequences that reduce misassignment due to index read errors associated with low sequence diversity.

    RNA PROBE FOR MUTATION PROFILING AND USE THEREOF
    6.
    发明公开
    RNA PROBE FOR MUTATION PROFILING AND USE THEREOF 审中-公开

    公开(公告)号：EP4202056A1

    公开(公告)日：2023-06-28

    申请号：EP21894688.7

    申请日：2021-11-17

    申请人： Xforest Therapeutics Co., Ltd.

    发明人： KOMATSU, Richard Kaoru ,  URTEL, Georg Christian ,  EDELEVA, Evgeniia

    IPC分类号： C12Q1/6806 ,  C12N15/09 ,  C40B40/06

    摘要： Provided is a method for analyzing a higher-order structure of RNA, the method comprising the steps of: (a) preparing one or a plurality of RNA probes, each comprising an RNA to be analyzed attached to a barcode sequence; (b) contacting the RNA probes and an RNA modification reagent; and (c) detecting a position and a frequency of modified nucleotides in a sequence of the RNA probe obtained in step (b), wherein each of the barcode sequences has a structure that has a reduced reactivity with the RNA modification reagent. The method improves the accuracy of detecting mutations, insertions, and deletions, etc., of a base introduced when carrying out mutation profiling using an RNA library.

    HALF-LIFE EXTENSION DRUG AND LIBRARY THEREOF, AND PREPARATION METHOD AND APPLICATION THEREOF
    9.
    发明公开
    HALF-LIFE EXTENSION DRUG AND LIBRARY THEREOF, AND PREPARATION METHOD AND APPLICATION THEREOF 审中-公开

    公开(公告)号：EP4053311A1

    公开(公告)日：2022-09-07

    申请号：EP20883596.7

    申请日：2020-10-26

    申请人： Assembly Medicine, LLC

    发明人： CHOU, James Jeiwen ,  PAN, Liqiang ,  RUN, Changqing ,  ZHOU, Liujuan

    IPC分类号： C40B40/06 ,  C40B40/10 ,  C07K19/00

    摘要： The present invention provides a half-life extension drug and a library thereof, and a preparation method and application thereof. Specifically, the present invention provides a drug library, comprising: (a) a drug unit; and (b) n half-life extension units, wherein the drug unit comprises a drug element portion and a first nucleic acid element portion connected to the drug element portion, and each half-life extension unit comprises a half-life extension element portion and a second nucleic acid element portion connected to the half-life extension element portion. Moreover, one first nucleic acid element portion of the drug unit and the second nucleic acid element portion of the at least one half-life extension unit may form a "drug unit-half-life extension unit" complex by forming a complementary base pairing structure, and n is a positive integer greater than or equal to 1.