公开(公告)号：EP3423596A1

公开(公告)日：2019-01-09

申请号：EP17709892.8

申请日：2017-02-27

申请人： Genentech, Inc. ,  Foundation Medicine, Inc.

发明人： BOURGON, Richard ,  FABRIZIO, David ,  FINE, Gregg ,  FRAMPTON, Garrett, M. ,  HEGDE, Priti ,  MARIATHASAN, Sanjeev ,  STEPHENS, Philip J. ,  SUN, James, Xin ,  YELENSKY, Roman

IPC分类号： C12Q1/68

公开(公告)号：EP4155415A1

公开(公告)日：2023-03-29

申请号：EP22191450.0

申请日：2017-02-27

申请人： GENENTECH, INC. ,  Foundation Medicine, Inc.

发明人： BOURGON, Richard ,  FABRIZIO, David ,  FINE, Gregg ,  FRAMPTON, Garrett, M. ,  HEGDE, Priti ,  MARIATHASAN, Sanjeev ,  STEPHENS, Philip J. ,  SUN, James, Xin ,  YELENSKY, Roman

IPC分类号： C12Q1/68

摘要： The present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, bladder cancer. The invention provides methods of treating bladder cancer, methods of determining whether a patient suffering from bladder cancer is likely to respond to treatment comprising a PD-L1 axis binding antagonist, methods of predicting responsiveness of a patient suffering bladder cancer to treatment comprising a PD-L1 axis binding antagonist, and methods of selecting a therapy for a patient suffering from bladder cancer, based on somatic mutation levels of genes of the invention (e.g., somatic mutation levels in a tumor sample obtained from the patient.

公开(公告)号：EP3423828A1

公开(公告)日：2019-01-09

申请号：EP17760558.1

申请日：2017-02-27

申请人： Foundation Medicine, Inc. ,  Genentech, Inc.

发明人： CHALMERS, Zachary R ,  CONNELLY, Caitlin F. ,  FABRIZIO, David ,  FRAMPTON, Garrett, Michaell ,  HEDGE, Priti ,  KOWANETZ, Marcin ,  STEPHENS, Philip J. ,  SUN, James, Xin ,  YELENSKY, Roman

IPC分类号： G01N33/50 ,  G01N33/574 ,  C40B20/04 ,  C40B30/02 ,  C40B40/06 ,  C40B70/00 ,  G06F19/22