公开(公告)号：EP3346011A1

公开(公告)日：2018-07-11

申请号：EP17202553.8

申请日：2009-03-11

申请人： Genomatica, Inc.

发明人： Wu, Liang ,  Trefzer, Axel Christoph ,  De Wildeman, Stefaan Marie André ,  Van Den Berg, Marco Alexander

IPC分类号： C12P7/44

CPC分类号： C12P7/44 ,  C12N15/70 ,  C12P7/62 ,  C12P17/10

摘要： This invention provides a host cell comprising nucleic acid sequences encoding an enzyme converting a 2,3-dehydroadipate ester or 2,3-dehydroadipate thioester into an adipate ester or thioester, an enzyme converting a 3-hydroxyadipate ester or 3-hydroxyadipate thioester into the 2,3-dehydroadipateester or 2,3-dehydroadipate thioester, an enzyme converting a 3-oxoadipate ester or 3-oxoadipate thioester into the 3-hydroxyadipate ester or thioester; and an enzyme reacting a succinate ester or succinate thioester with an acetate ester or acetate thioester and generating the 3-oxoadipate ester or 3-oxoadipate thioester.