公开(公告)号：EP4419703A1

公开(公告)日：2024-08-28

申请号：EP22808683.1

申请日：2022-10-19

申请人： DSM IP Assets B.V.

发明人： VYAS, Valmik Kanubhai ,  HOUSTON, Peter Louis ,  MCMAHON, Jenna ,  DE JONG, René Marcel

IPC分类号： C12P23/00 ,  C12P7/62 ,  C12N9/04 ,  A61K31/07 ,  C12R1/73 ,  C12R1/78

CPC分类号： C12P23/00 ,  C12P7/62 ,  C12N9/0006 ,  C12Y101/01105 ,  C12R2001/7320210501 ,  C12R2001/7820210501 ,  A61K31/07

公开(公告)号：EP3378931A1

公开(公告)日：2018-09-26

申请号：EP17162104.8

申请日：2017-03-21

申请人： Purac Biochem B.V.

发明人： de Bont, Johannes Adrianus Maria ,  Ruijssenaars, Harald Johan ,  Werij, Jan

IPC分类号： C12N1/15 ,  C12N1/19 ,  C07K14/385 ,  C12N9/02 ,  C12P17/04

CPC分类号： C12N9/0073 ,  C07K14/385 ,  C12P7/42 ,  C12P7/44 ,  C12P7/62 ,  C12P17/04

摘要： The invention relates to fungal cells for the production of FDCA. The fungal cell has genetic modification that reduces specific 2,5-furandicarboxylic acid (FDCA) decarboxylating monooxygenase activity in the cell, as compared to a corresponding parent cell lacking the genetic modification. The fungal cell can further be genetically modified to increase the cell's ability to oxidize furanic aldehydes to the corresponding furanic carboxylic acids. The invention also relates to a process for the production of 2,5-furan-dicarboxylic acid (FDCA) wherein the cells of the invention are used for oxidation of a furanic precursors of FDCA to FDCA.

公开(公告)号：EP3353313A2

公开(公告)日：2018-08-01

申请号：EP16778886.8

申请日：2016-09-22

申请人： Pfizer Inc.

发明人： HILLER, Gregory Walter ,  MITCHELL, Jeffrey Joseph ,  MULUKUTLA, Bhanu Chandra ,  PEGMAN, Pamela Mary

IPC分类号： C12P21/00 ,  C07K16/00 ,  C07K14/435

CPC分类号： C12P7/62 ,  C07K16/00 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2510/00 ,  C12N2510/02 ,  C12N2511/00 ,  C12P7/40 ,  C12P7/42 ,  C12P7/52 ,  C12P7/56 ,  C12P17/182

摘要： The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell. The invention also relates to a method of cell culture for improving cell growth and productivity, in particular in fed-batch culture of mammalian cells at high cell density. The invention further relates to a method of producing cells with improved cell growth and/or productivity in cell culture and to cells obtained or obtainable by such methods.

公开(公告)号：EP3346011A1

公开(公告)日：2018-07-11

申请号：EP17202553.8

申请日：2009-03-11

申请人： Genomatica, Inc.

发明人： Wu, Liang ,  Trefzer, Axel Christoph ,  De Wildeman, Stefaan Marie André ,  Van Den Berg, Marco Alexander

IPC分类号： C12P7/44

CPC分类号： C12P7/44 ,  C12N15/70 ,  C12P7/62 ,  C12P17/10

摘要： This invention provides a host cell comprising nucleic acid sequences encoding an enzyme converting a 2,3-dehydroadipate ester or 2,3-dehydroadipate thioester into an adipate ester or thioester, an enzyme converting a 3-hydroxyadipate ester or 3-hydroxyadipate thioester into the 2,3-dehydroadipateester or 2,3-dehydroadipate thioester, an enzyme converting a 3-oxoadipate ester or 3-oxoadipate thioester into the 3-hydroxyadipate ester or thioester; and an enzyme reacting a succinate ester or succinate thioester with an acetate ester or acetate thioester and generating the 3-oxoadipate ester or 3-oxoadipate thioester.

公开(公告)号：EP3323887A2

公开(公告)日：2018-05-23

申请号：EP17202327.7

申请日：2004-01-15

申请人： DuPont Nutrition Biosciences ApS

发明人： DE KREIJ, Arno ,  MADRID, Susan Mampusti ,  MIKKELSEN, Jørn ,  SØE, Jørn Borch

IPC分类号： C12N9/10 ,  C12N9/18 ,  C12N11/00 ,  C12P7/62 ,  C12P7/64 ,  A23L29/00 ,  A23L29/10

CPC分类号： A21D8/042 ,  A23C19/0328 ,  A23D7/013 ,  A23G9/363 ,  A23L15/25 ,  A23L27/60 ,  A23L29/06 ,  A23L29/10 ,  A23L33/11 ,  C11C3/10 ,  C12N9/1029 ,  C12P7/62 ,  C12P7/6436 ,  C12P7/6454 ,  C12P7/6481 ,  C12Q1/48 ,  C12Y203/01 ,  C12Y301/01 ,  C12Y301/01003 ,  C12Y301/01026 ,  C12Y301/01032 ,  G01N2333/91051 ,  G01N2333/918

摘要： A method for the in situ production of an emulsifier in a foodstuff, wherein a lipid acyltransferase is added to the foodstuff. Preferably the emulsifier is produced without an increase or without a substantial increase in the free fatty acid content of the foodstuff. Preferably, the lipid acyltransferase is one which is capable of transferring an acyl group from a lipid to one or more of the following acyl acceptors: a sterol, a stanol, a carbohydrate, a protein or a sub-unit thereof, glycerol. Preferably, in addition to an emulsifier one or more of a stanol ester or a stanol ester or a protein ester or a carbohydrate ester or a diglyceride or a monoglyceride may be produced. One or more of these may function as an additional emulsifier.

公开(公告)号：EP3171966A4

公开(公告)日：2018-03-14

申请号：EP15825266

申请日：2015-07-21

申请人： XYLECO INC

发明人： MEDOFF MARSHALL ,  MASTERMAN THOMAS CRAIG ,  CAHILL JOHN M

IPC分类号： B01D61/58 ,  B04B1/00 ,  C12P19/00 ,  C13B20/16 ,  C13K1/04 ,  C13K1/08

CPC分类号： C13B20/165 ,  B01D61/02 ,  B01D61/142 ,  B01D61/44 ,  B01D61/58 ,  B01D2311/2688 ,  B01D2315/12 ,  B01D2317/025 ,  C12P7/10 ,  C12P7/62 ,  C12P19/02 ,  C13K1/04 ,  C13K13/002

摘要： Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can be useful for separating solids and high molecular weight species from liquids of bioprocessed biomass material slurries.

公开(公告)号：EP2875179B1

公开(公告)日：2018-02-21

申请号：EP13819379.2

申请日：2013-07-18

申请人： Novozymes A/S

发明人： SUN, Ting ,  DE MARIA, Leonardo ,  LAI, Weijian

IPC分类号： D06M16/00 ,  D06M101/32 ,  C12N9/24 ,  C12N9/16

CPC分类号： C12P7/62 ,  C12N9/24 ,  C12Y301/01074 ,  D06M16/003 ,  D06M2101/32

摘要： The present invention relates to the use of glycosyl hydrolase family 61 polypeptides in the presence of cutinases for polyester textile manufacture as well as a textile composition comprising glycosyl hydrolase family 61 polypeptides and cutinases.

公开(公告)号：EP2841568B1

公开(公告)日：2018-02-21

申请号：EP13718528.6

申请日：2013-04-12

申请人： Evonik Technochemie GmbH

发明人： GERSTMEIR, Robert ,  WIEGRÄBE, Iris

IPC分类号： C12N9/10 ,  C12P13/06

CPC分类号： C12N9/1025 ,  C12N1/20 ,  C12N15/74 ,  C12N15/77 ,  C12P7/40 ,  C12P7/62 ,  C12P13/06 ,  C12Y203/03013 ,  Y02P20/52

摘要： The invention relates to an isolated nucleotide sequence encoding an amino acid sequence that is at least ≧90%, ≧92%, ≧94%, ≧96%, ≧97%, ≧98%, ≧99% or 100%, preferably ≧97%, particularly preferably ≧98%, very particularly preferably ≧99%, and extremely preferably 0%, identical to the amino acid sequence of SEQ ID NO:2, wherein SEQ ID NO:2, at position 553, or at a corresponding position of the amino acid sequence, has a proteinogenic amino acid other than L-tyrosine, to a microorganism comprising the nucleotide sequence and also to a process for producing fine chemicals using this microorganism.

公开(公告)号：EP2956434B1

公开(公告)日：2017-12-27

申请号：EP14704774.0

申请日：2014-02-13

申请人： Purac Biochem bv

发明人： VAN KRIEKEN, Jan ,  DE HAAN, André Banier ,  VAN BREUGEL, Jan

IPC分类号： C07C67/08 ,  C07C69/68

CPC分类号： C07C29/095 ,  C07C29/149 ,  C07C67/08 ,  C07C67/38 ,  C12P7/62 ,  C07C69/68

公开(公告)号：EP2666855B1

公开(公告)日：2017-11-22

申请号：EP11855954.1

申请日：2011-01-20

申请人： TOYOTA JIDOSHA KABUSHIKI KAISHA

发明人： MURAMATSU Masayoshi ,  ITO Masakazu

IPC分类号： C12N15/09 ,  C12N1/19 ,  C12P7/04 ,  C12R1/865

CPC分类号： C12N9/0006 ,  C12N9/1205 ,  C12N9/13 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12N15/81 ,  C12P7/02 ,  C12P7/04 ,  C12P7/54 ,  C12P7/62 ,  C12P19/32 ,  C12Y101/01001 ,  C12Y207/01011 ,  C12Y208/03008 ,  C12Y401/01004 ,  C12Y401/02009 ,  Y02P20/52

摘要： Substance productivity is improved by introducing a metabolic pathway for synthesis of acetyl-CoA or acetic acid from glucose-6-phosphate into yeast. Acetic acid productivity, acetyl-CoA productivity, and productivity of a substance made from acetyl-CoA-derived are improved by attenuating genes involved in the glycolytic system of yeast and introducing a phosphoketolase gene into the yeast.