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    Gene expression markers for colorectal cancer prognosis
    6.
    发明公开
    Gene expression markers for colorectal cancer prognosis 有权
    Genexpressionsmarker zur Kolorektalkrebsprognose

    公开(公告)号：EP2377950A1

    公开(公告)日：2011-10-19

    申请号：EP10177406.5

    申请日：2007-01-11

    申请人： Genomic Health, Inc. ,  NSABP Foundation, Inc.

    发明人： Cowens, Wayne ,  Baker, Joffre B. ,  Clark, Kim ,  Hackett, James ,  Watson, Drew ,  Paik, Soonmyung

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  G01N33/57419 ,  G01N33/57446

    摘要： A method of predicting clinical outcome for a human subject diagnosed with colorectal cancer following surgical resection of said cancer is disclosed. A normalized expression level is determined of an RNA transcript of MYBL2, or an expression product thereof, in a biological sample comprising cancer cells obtained from said human subject. The likelihood of a positive clinical outcome for said human subject is then predicted based on said normalized expression level, wherein normalized expression of an RNA transcript of MYBL2, or an expression product thereof, is positively correlated with an increased likelihood of a positive clinical outcome.

    摘要翻译： 公开了一种用于预测所述癌症手术切除后诊断为结肠直肠癌的人类受试者的临床结果的方法。 在包含从所述人受试者获得的癌细胞的生物样品中确定MYBL2或其表达产物的RNA转录物的归一化表达水平。 然后基于所述归一化表达水平预测所述人受试者的阳性临床结果的可能性，其中MYBL2或其表达产物的RNA转录物的标准化表达与阳性临床结果的增加的可能性呈正相关。