公开(公告)号：EP2377950A1

公开(公告)日：2011-10-19

申请号：EP10177406.5

申请日：2007-01-11

申请人： Genomic Health, Inc. ,  NSABP Foundation, Inc.

发明人： Cowens, Wayne ,  Baker, Joffre B. ,  Clark, Kim ,  Hackett, James ,  Watson, Drew ,  Paik, Soonmyung

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  G01N33/57419 ,  G01N33/57446

摘要： A method of predicting clinical outcome for a human subject diagnosed with colorectal cancer following surgical resection of said cancer is disclosed. A normalized expression level is determined of an RNA transcript of MYBL2, or an expression product thereof, in a biological sample comprising cancer cells obtained from said human subject. The likelihood of a positive clinical outcome for said human subject is then predicted based on said normalized expression level, wherein normalized expression of an RNA transcript of MYBL2, or an expression product thereof, is positively correlated with an increased likelihood of a positive clinical outcome.

摘要翻译： 公开了一种用于预测所述癌症手术切除后诊断为结肠直肠癌的人类受试者的临床结果的方法。 在包含从所述人受试者获得的癌细胞的生物样品中确定MYBL2或其表达产物的RNA转录物的归一化表达水平。 然后基于所述归一化表达水平预测所述人受试者的阳性临床结果的可能性，其中MYBL2或其表达产物的RNA转录物的标准化表达与阳性临床结果的增加的可能性呈正相关。

公开(公告)号：EP2377950B1

公开(公告)日：2014-09-17

申请号：EP10177406.5

申请日：2007-01-11

申请人： Genomic Health, Inc. ,  NSABP Foundation, Inc.

发明人： Cowens, Wayne ,  Baker, Joffre B. ,  Clark, Kim ,  Hackett, James ,  Watson, Drew ,  Paik, Soonmyung

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  G01N33/57419 ,  G01N33/57446

公开(公告)号：EP2230319A3

公开(公告)日：2011-01-12

申请号：EP10162868.3

申请日：2004-01-14

申请人： Genomic Health, Inc.

发明人： Cobleigh, Melody A. ,  Shak, Steven ,  Baker, Joffre B. ,  Cronin, Maureen T.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.

公开(公告)号：EP2241636A1

公开(公告)日：2010-10-20

申请号：EP10158616.2

申请日：2003-03-12

申请人： Genomic Health, Inc.

发明人： Baker, Joffre B. ,  Cronin, Maureen T. ,  Kiefer, Michael C. ,  Shak, Steve ,  Walker, Michael G.

IPC分类号： C12Q1/68

CPC分类号： G01N33/57484 ,  C12N15/1003 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415

摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

公开(公告)号：EP2230319A2

公开(公告)日：2010-09-22

申请号：EP10162868.3

申请日：2004-01-14

申请人： Genomic Health, Inc. ,  Rush University Medical Center

发明人： Cobleigh, Melody A. ,  Shak, Steven ,  Baker, Joffre B. ,  Cronin, Maureen T.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.

摘要翻译： 本发明提供了其表达在乳腺癌的诊断和/或预后中重要的基因组。

公开(公告)号：EP4083233A3

公开(公告)日：2023-01-25

申请号：EP22168567.0

申请日：2011-07-25

申请人： Genomic Health, Inc.

发明人： Shak, Steven ,  Baehner, Frederick ,  Maddala, Tara ,  Lee, Mark ,  Pelham, Robert ,  Cowens, Wayne ,  Cherbavaz, Diana ,  Kiefer, Michael ,  Crager, Michael ,  Goddard, Audrey ,  Baker, Joffre B.

IPC分类号： C12Q1/6886 ,  G01N33/574

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or coexpressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

公开(公告)号：EP4083233A2

公开(公告)日：2022-11-02

申请号：EP22168567.0

申请日：2011-07-25

申请人： Genomic Health, Inc.

发明人： Shak, Steven ,  Baehner, Frederick ,  Maddala, Tara ,  Lee, Mark ,  Pelham, Robert ,  Cowens, Wayne ,  Cherbavaz, Diana ,  Kiefer, Michael ,  Crager, Michael ,  Goddard, Audrey ,  Baker, Joffre B.

IPC分类号： C12Q1/6886 ,  G01N33/574

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or coexpressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

公开(公告)号：EP2261369B1

公开(公告)日：2014-05-14

申请号：EP10158652.7

申请日：2003-03-12

申请人： Genomic Health, Inc.

发明人： Baker, Joffre B. ,  Cronin, Maureen T. ,  Kiefer, Michael C. ,  Shak, Steve ,  Walker, Michael G.

IPC分类号： C12Q1/68

CPC分类号： G01N33/57484 ,  C12N15/1003 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415

摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

公开(公告)号：EP2258872A3

公开(公告)日：2011-05-04

申请号：EP10158642.8

申请日：2003-03-12

申请人： Genomic Health, Inc.

发明人： Baker, Joffre B. ,  Cronin, Maureen T. ,  Kiefer, Michael C. ,  Shak, Steve ,  Walker, Michael G.

IPC分类号： C12Q1/68

CPC分类号： G01N33/57484 ,  C12N15/1003 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415

摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

公开(公告)号：EP2226396A1

公开(公告)日：2010-09-08

申请号：EP10158352.4

申请日：2004-05-28

申请人： Genomic Health, Inc. ,  Cedars-Sinai Medical Center

发明人： Baker, Joffre B. ,  Shak, Steve ,  Agus, David ,  Natale, Ronald

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

摘要： The present invention concerns prognostic markers associated with cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed samples of cancer tissue, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.

摘要翻译： 本发明涉及与癌症相关的预后标志物。 特别地，本发明涉及基于在石蜡包埋的癌症组织的固定样品中的基因表达的分子表征的预后方法，其允许医师预测患者是否可能对EGFR抑制剂治疗反应良好。