ANTI-TRANSGLUTAMINASE 2 ANTIBODIES
    3.
    发明公开

    公开(公告)号:EP3521315A1

    公开(公告)日:2019-08-07

    申请号:EP19163818.8

    申请日:2013-05-24

    申请人: LifeArc

    IPC分类号: C07K16/40 A61K39/00 A61K51/10

    摘要: The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.