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公开(公告)号:EP3861023A1
公开(公告)日:2021-08-11
申请号:EP19782593.8
申请日:2019-10-02
发明人: BAYER, Thomas , BAKRANIA, Preeti , DAVIES, Sarah , BROWN, Alex , MPAMHANGA, Chido , MATTHEWS, David , CARR, Mark , HALL, Gareth
IPC分类号: C07K16/18 , A61P25/28 , A61K39/395 , A61K39/00
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公开(公告)号:EP4118111A1
公开(公告)日:2023-01-18
申请号:EP21711536.9
申请日:2021-03-10
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公开(公告)号:EP3521315A1
公开(公告)日:2019-08-07
申请号:EP19163818.8
申请日:2013-05-24
申请人: LifeArc
发明人: JOHNSON, Tim , WATSON, Phil , MATTHEWS, David , BROWN, Alex
摘要: The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.
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公开(公告)号:EP3891180A1
公开(公告)日:2021-10-13
申请号:EP19817661.2
申请日:2019-12-06
申请人: LifeArc
发明人: PATEL, Seema , MATTHEWS, David
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公开(公告)号:EP2855530B1
公开(公告)日:2019-05-01
申请号:EP13730049.7
申请日:2013-05-24
申请人: LifeArc
发明人: JOHNSON, Tim , WATSON, Phil , MATTHEWS, David , BROWN, Alex
IPC分类号: C07K16/40
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