公开(公告)号：EP2694479A1

公开(公告)日：2014-02-12

申请号：EP12713571.3

申请日：2012-04-03

申请人： Gilead Sciences, Inc.

发明人： LI, Wenjie ,  DE CROOS, Philomen ,  FANDRICK, Keith, R. ,  GAO, Joe, Ju ,  HADDAD, Nizar ,  LU, Zhi-Hui ,  QU, Bo ,  RODRIGUEZ, Sonia ,  SENANAYAKE, Chris, H. ,  ZHANG, Yongda ,  TANG, Wenjun

IPC分类号： C07D215/14 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  C07D491/06

CPC分类号： C07D491/06 ,  C07D215/14 ,  C07D401/02 ,  C07D401/04 ,  C07D405/02 ,  C07D405/04 ,  C07D409/02 ,  C07D409/04 ,  C07D417/02 ,  C07D417/04

摘要： The present invention is directed to an improved process for the preparation of Compounds of Formula (I) or salts thereof which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)- 2-methylquinolin-3-yl)acetic acid or salt thereof which is useful in the treatment of HIV infection. R
4 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n) and (o); and R
6 and R
7 are each independently selected from H, halo and (C
1-6 ) alkyl.