公开(公告)号：EP1694327A2

公开(公告)日：2006-08-30

申请号：EP04813056.1

申请日：2004-12-03

申请人： GLAXO GROUP LIMITED

发明人： BUSCH-PETERSEN, Jakob ,  JIN, Jian ,  PALOVICH, Michael R. ,  FU, Wei

IPC分类号： A61K31/445 ,  C07D211/56

CPC分类号： C07D211/56 ,  C07D215/36 ,  C07D263/46 ,  C07D277/44 ,  C07D317/46 ,  C07D333/34 ,  C07D401/12 ,  C07D405/06 ,  C07D409/02 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14

摘要： Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

公开(公告)号：EP4431493A1

公开(公告)日：2024-09-18

申请号：EP22894817.0

申请日：2022-11-16

申请人： Shenzhen Bay Laboratory ,  Peking University Shenzhen Graduate School

发明人： ZHU, Zhendong ,  XU, Zhengshuang ,  LI, Ting ,  CHE, Chao ,  REN, Xingye ,  CHEN, Sigui ,  ZHANG, Jiayin ,  ZHANG, Ben ,  YANG, Qi ,  ZHANG, Chuanbing ,  YANG, Zhen

IPC分类号： C07D205/04 ,  C07D213/30 ,  C07D401/02 ,  C07D401/14 ,  C07D409/02 ,  C07D403/14 ,  C07C65/26 ,  C07C63/49 ,  A61K31/44 ,  A61K31/4025 ,  A61K31/397 ,  A61K31/404 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P31/22

CPC分类号： A61K31/397 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/506 ,  A61P19/02 ,  A61P29/00 ,  A61P31/00 ,  A61P31/22 ,  A61P35/00 ,  A61P35/02 ,  A61P39/00 ,  C07C63/49 ,  C07C65/26 ,  C07D205/04 ,  C07D213/30 ,  C07D213/56 ,  C07D213/75 ,  C07D401/02 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D409/02 ,  C07D409/14 ,  C07D417/14

摘要： A small molecule inhibitor targeting EB virus antigen protein, and/or a pharmaceutical composition comprising same, capable of being used for treating diseases caused by EB virus infection, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus or rheumatoid arthritis, especially nasopharyngeal carcinoma. The present invention further provides a small molecule inhibitor against nasopharyngeal carcinoma, and/or a pharmaceutical composition comprising same, capable of being used for treating nasopharyngeal carcinoma.

公开(公告)号：EP3363786A1

公开(公告)日：2018-08-22

申请号：EP17156326.5

申请日：2017-02-15

申请人： Merck Patent GmbH

发明人： The designation of the inventor has not yet been filed

IPC分类号： C07D209/12 ,  C07D307/80 ,  C07D307/82 ,  C07D307/83 ,  C07D333/64 ,  C07D405/04 ,  C07D409/02 ,  A61F2/16 ,  A61F9/00 ,  G02B1/04

CPC分类号： C07D209/12 ,  C07D307/80 ,  C07D307/82 ,  C07D307/83 ,  C07D333/64 ,  C07D405/04 ,  C07D409/02

摘要： The present invention relates to novel compounds (I) particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprising such compounds.

公开(公告)号：EP1423381A1

公开(公告)日：2004-06-02

申请号：EP02761567.3

申请日：2002-09-05

申请人： Schering Corporation

发明人： GUZI, Timothy J. ,  PARUCH, Kamil ,  MALLAMS, Alan K. ,  RIVERA, Jocelyn, D. ,  DOLL, Ronald, J. ,  GIRIJAVALLABHAN, Viyyoor, M. ,  PACHTER, Jonathan ,  LIU, Yi-Tsung ,  SAKSENA, Anil, K.

IPC分类号： C07D401/06 ,  A61K31/496 ,  C07D241/04 ,  C07D409/14 ,  A61P35/00

CPC分类号： C07D211/34 ,  C07D211/48 ,  C07D295/185 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/02 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12

摘要： There are disclosed compounds of the formula (I), prodrugs thereof, or pharmaceutically acceptable salts of the compounds or of said prodrugs which are useful as inhibitors of Type 3 17beta-Hydroxysteroid Dehydrogenase. Also disclosed are pharmaceutical compositions containing said compounds and their use for the treatment or prevention of androgen dependent diseases.

公开(公告)号：EP2694479A1

公开(公告)日：2014-02-12

申请号：EP12713571.3

申请日：2012-04-03

申请人： Gilead Sciences, Inc.

发明人： LI, Wenjie ,  DE CROOS, Philomen ,  FANDRICK, Keith, R. ,  GAO, Joe, Ju ,  HADDAD, Nizar ,  LU, Zhi-Hui ,  QU, Bo ,  RODRIGUEZ, Sonia ,  SENANAYAKE, Chris, H. ,  ZHANG, Yongda ,  TANG, Wenjun

IPC分类号： C07D215/14 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  C07D491/06

CPC分类号： C07D491/06 ,  C07D215/14 ,  C07D401/02 ,  C07D401/04 ,  C07D405/02 ,  C07D405/04 ,  C07D409/02 ,  C07D409/04 ,  C07D417/02 ,  C07D417/04

摘要： The present invention is directed to an improved process for the preparation of Compounds of Formula (I) or salts thereof which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)- 2-methylquinolin-3-yl)acetic acid or salt thereof which is useful in the treatment of HIV infection. R
4 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n) and (o); and R
6 and R
7 are each independently selected from H, halo and (C
1-6 ) alkyl.

公开(公告)号：EP1423381B1

公开(公告)日：2007-01-03

申请号：EP02761567.3

申请日：2002-09-05

申请人： SCHERING CORPORATION

发明人： GUZI, Timothy J. ,  PARUCH, Kamil ,  MALLAMS, Alan K. ,  RIVERA, Jocelyn, D. ,  DOLL, Ronald, J. ,  GIRIJAVALLABHAN, Viyyoor, M. ,  PACHTER, Jonathan ,  LIU, Yi-Tsung ,  SAKSENA, Anil, K.

IPC分类号： C07D401/06 ,  A61K31/496 ,  C07D241/04 ,  C07D409/14 ,  A61P35/00

CPC分类号： C07D211/34 ,  C07D211/48 ,  C07D295/185 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/02 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12

摘要： There are disclosed compounds of the formula (I), prodrugs thereof, or pharmaceutically acceptable salts of the compounds or of said prodrugs which are useful as inhibitors of Type 3 17beta-Hydroxysteroid Dehydrogenase. Also disclosed are pharmaceutical compositions containing said compounds and their use for the treatment or prevention of androgen dependent diseases.

公开(公告)号：EP1530470A1

公开(公告)日：2005-05-18

申请号：EP03765254.2

申请日：2003-07-16

申请人： ELI LILLY AND COMPANY

发明人： DALLY, Robert, Dean ,  DODGE, Jeffrey, Alan ,  FRANK, Scott, Alan ,  JONES, Scott, Alan ,  SHEPHERD, Timothy, Alan ,  WALLACE, Owen, Brendan ,  FONG, Kin, Chiu ,  HUMMEL, Conrad, Wilson ,  LEWIS, Geroge, Sal

IPC分类号： A61K31/4453 ,  A61P5/32 ,  C07D295/08 ,  C07D333/56 ,  C07D333/72 ,  C07D295/12 ,  C07D333/64

CPC分类号： C07D295/088 ,  C07D295/13 ,  C07D333/56 ,  C07D333/64 ,  C07D333/72 ,  C07D409/02

摘要： The present invention relates to a selective estrogen receptor modulator of formula I or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata.

公开(公告)号：EP3339304A1

公开(公告)日：2018-06-27

申请号：EP16382629.0

申请日：2016-12-20

申请人： Laboratorios del Dr. Esteve, S.A.

发明人： ALMANSA-ROSALES, Carmen ,  YENES-MINGUEZ, Susana ,  VIRGILI-BERNADÓ, Marina ,  ALONSO-XALMA, Mónica

IPC分类号： C07D401/12 ,  C07D405/12 ,  C07D409/02 ,  C07D409/06 ,  C07D417/12 ,  A61K31/47 ,  A61K31/4725

CPC分类号： C07D409/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/02 ,  C07D417/12

摘要： The present invention relates to new compounds of formula (I):

showing great affinity and activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels or dual activity towards subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET).

公开(公告)号：EP3154954A4

公开(公告)日：2018-06-13

申请号：EP15806027

申请日：2015-06-09

申请人： SANFORD BURNHAM MEDICAL RES INSTITUTE

发明人： COSFORD NICHOLAS DAVID PETER ,  RAVEENDRA-PANICKAR DHANYA ,  SHEFFLER DOUGLAS J

IPC分类号： C07D277/20 ,  A61K31/4196 ,  A61K31/426 ,  A61K31/427 ,  A61K31/433 ,  C07D217/06 ,  C07D249/08 ,  C07D285/08 ,  C07D417/04

CPC分类号： C07D417/14 ,  A61K31/4196 ,  A61K31/426 ,  A61K31/427 ,  A61K31/433 ,  A61K31/505 ,  A61K31/506 ,  C07D217/06 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D239/26 ,  C07D243/12 ,  C07D249/08 ,  C07D261/08 ,  C07D263/32 ,  C07D271/06 ,  C07D275/02 ,  C07D277/20 ,  C07D277/26 ,  C07D277/30 ,  C07D285/08 ,  C07D307/38 ,  C07D333/24 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/10 ,  C07D409/02 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/10

摘要： Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

公开(公告)号：EP3197869A1

公开(公告)日：2017-08-02

申请号：EP15845068.4

申请日：2015-09-25

申请人： Rohm And Haas Electronic Materials Korea Ltd.

发明人： MOON, Doo-Hyeon ,  YANG, Jeong-Eun ,  KANG, Hee-Ryong ,  LIM, Young-Mook ,  JUN, Ji-Song ,  AHN, Hee-Choon ,  HONG, Jin-Ri ,  LEE, Su-Hyun ,  KIM, Bitnari ,  LEE, Tae-Jin

IPC分类号： C07D209/86 ,  H01L51/50 ,  H01L51/54 ,  C09K11/06 ,  C07D405/02 ,  C07D405/04 ,  C07D409/02 ,  C07D409/04 ,  C07D209/82 ,  C07D209/88

CPC分类号： H01L51/0072 ,  C07D209/56 ,  C07D209/82 ,  C07D209/86 ,  C07D209/88 ,  C07D405/02 ,  C07D405/04 ,  C07D405/10 ,  C07D409/02 ,  C07D409/04 ,  C07D409/10 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1018 ,  C09K2211/1029 ,  C09K2211/1059 ,  C09K2211/1088 ,  C09K2211/1092 ,  H01L51/0052 ,  H01L51/0054 ,  H01L51/0056 ,  H01L51/0067 ,  H01L51/0074 ,  H01L51/0085 ,  H01L51/5012 ,  H01L51/5016 ,  H01L51/5056 ,  H01L2251/5384

摘要： The present disclosure relates to an organic electroluminescent compound, and an organic electroluminescent material and an organic electroluminescent device comprising the same. The organic electroluminescent compound of the present disclosure has excellent color purity, solubility, and thermal stability. By comprising the organic electroluminescent compound and the organic electroluminescent material of the present disclosure, an organic electroluminescent device showing low driving voltage, excellent current and power efficiencies, and significantly improved lifespan can be provided.

摘要翻译： 有机电致发光化合物，有机电致发光材料和包含其的有机电致发光器件技术领域本发明涉及有机电致发光化合物， 根据本发明的有机电致发光化合物具有优异的色纯度，溶解度和热稳定性，并且根据本发明的有机电致发光化合物或包含其的有机电致发光材料用于制造具有 低驱动电压，出色的电流效率和功率效率，并延长使用寿命。 有机电致发光化合物由化学式1表示。