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1.发明授权GP100-specific T cell receptors and related materials and methods of use 有权具体GP100-T细胞受体和相应的材料和使用的方法
公开(公告)号：EP2102236B1
公开(公告)日：2014-08-06
申请号：EP08727582.2
申请日：2008-01-11
IPC分类号： C07K14/705 , A61K38/17
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/7051 , C07K16/30 , C12N15/85 , C12N15/86 , G01N33/57492
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2.发明公开
公开(公告)号：EP2016102A2
公开(公告)日：2009-01-21
申请号：EP07797329.5
申请日：2007-05-03
IPC分类号： C07K19/00 , C07K14/725
CPC分类号： C07K14/7051 , C07K2319/00 , G01N33/6893
摘要： The invention provides a chimeric T cell receptor (TCR) comprising a variable region of a human TCR and a constant region comprising at least an extracellular domain of a constant region of a non-human TCR, as well as functional variants thereof. The invention also provides polypeptides and proteins related to the inventive TCRs, as well as nucleic acids encoding the TCRs, polypeptides, or proteins, recombinant expression vectors, and host cells. Further provided are pharmaceutical compositions related to the inventive TCRs and methods of preventing or treating a disease, e.g., an infectious disease, cancer, in a host, methods of detecting a diseased cell in a host, and methods of improving the biological activity of a TCR.
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3.发明授权
公开(公告)号：EP2016102B1
公开(公告)日：2012-03-21
申请号：EP07797329.5
申请日：2007-05-03
IPC分类号： C07K19/00 , C07K14/725
CPC分类号： C07K14/7051 , C07K2319/00 , G01N33/6893
摘要： The invention provides a chimeric T cell receptor (TCR) comprising a variable region of a human TCR and a constant region comprising at least an extracellular domain of a constant region of a non-human TCR, as well as functional variants thereof. The invention also provides polypeptides and proteins related to the inventive TCRs, as well as nucleic acids encoding the TCRs, polypeptides, or proteins, recombinant expression vectors, and host cells. Further provided are pharmaceutical compositions related to the inventive TCRs and methods of preventing or treating a disease, e.g., an infectious disease, cancer, in a host, methods of detecting a diseased cell in a host, and methods of improving the biological activity of a TCR.
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4.发明公开AUTOLOGOUS NATURAL KILLER CELLS AND LYMPHODEPLETING CHEMOTHERAPY FOR THE TREATMENT OF CANCER 审中-公开自体自然杀伤细胞和LYMPHVERMINDERNDE癌症化疗
公开(公告)号：EP1991663A2
公开(公告)日：2008-11-19
申请号：EP07757951.4
申请日：2007-03-06
CPC分类号： C12N5/0646 , A61K38/2013 , C12N2501/23 , C12N2501/998 , C12N2502/11 , A61K2300/00
摘要： The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.
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5.发明公开GP100-SPECIFIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE 有权具体GP100-T细胞受体和相应的材料和使用的方法
公开(公告)号：EP2102236A2
公开(公告)日：2009-09-23
申请号：EP08727582.2
申请日：2008-01-11
IPC分类号： C07K14/725
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/7051 , C07K16/30 , C12N15/85 , C12N15/86 , G01N33/57492
摘要： The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.
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