公开(公告)号：EP3394063B1

公开(公告)日：2019-10-02

申请号：EP16816710.4

申请日：2016-12-23

申请人： Guerbet ,  Université de Bretagne Occidentale ,  Centre National de la Recherche Scientifique

发明人： LE FUR, Mariane ,  TRIPIER, Raphaël ,  ROUSSEAUX, Olivier ,  BEYLER, Maryline

IPC分类号： C07D471/08 ,  C07D471/18 ,  A61K31/439 ,  A61P35/00

公开(公告)号：EP3645534A1

公开(公告)日：2020-05-06

申请号：EP18733626.8

申请日：2018-06-28

申请人： Guerbet ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  Université de Bretagne Occidentale

发明人： TRIPIER, Raphaël ,  ROUSSEAUX, Olivier ,  LE FUR, Mariane ,  BEYLER, Maryline ,  FOUGÈRE, Olivier ,  NIZOU, Gwladys

IPC分类号： C07D471/18 ,  A61K31/439 ,  A61P35/00

公开(公告)号：EP3394063A1

公开(公告)日：2018-10-31

申请号：EP16816710.4

申请日：2016-12-23

申请人： Guerbet ,  Université de Bretagne Occidentale ,  Centre National de la Recherche Scientifique

发明人： LE FUR, Mariane ,  TRIPIER, Raphaël ,  ROUSSEAUX, Olivier ,  BEYLER, Maryline

IPC分类号： C07D471/08 ,  C07D471/18 ,  A61K31/439 ,  A61P35/00

CPC分类号： C07D471/18 ,  A61K31/439 ,  A61K36/66 ,  A61K45/06 ,  C07D471/08

摘要： The present invention relates to novel macrocyclic ligands substituted with at least one picolinate group, to the compounds of general formula (I), and also to the radioactive complexes thereof and to the uses thereof in medical imaging and/or in therapy, in particular in interventional radiology. The present invention also relates to a novel process for preparing the ligands according to the invention, and also to the preparation intermediates thereof. In which formula (I) Y
1 , Y
2 and Y
3 are independently a -C(O)OH group or a group of formula (II), at least one of the radicals Y
1 , Y
2 and Y
3 being a group of formula (II).