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公开(公告)号：EP3394063B1
公开(公告)日：2019-10-02
申请号：EP16816710.4
申请日：2016-12-23
IPC分类号： C07D471/08 , C07D471/18 , A61K31/439 , A61P35/00
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公开(公告)号：EP3645534A1
公开(公告)日：2020-05-06
申请号：EP18733626.8
申请日：2018-06-28
发明人： TRIPIER, Raphaël , ROUSSEAUX, Olivier , LE FUR, Mariane , BEYLER, Maryline , FOUGÈRE, Olivier , NIZOU, Gwladys
IPC分类号： C07D471/18 , A61K31/439 , A61P35/00
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3.发明公开
公开(公告)号：EP3394063A1
公开(公告)日：2018-10-31
申请号：EP16816710.4
申请日：2016-12-23
IPC分类号： C07D471/08 , C07D471/18 , A61K31/439 , A61P35/00
CPC分类号： C07D471/18 , A61K31/439 , A61K36/66 , A61K45/06 , C07D471/08
摘要： The present invention relates to novel macrocyclic ligands substituted with at least one picolinate group, to the compounds of general formula (I), and also to the radioactive complexes thereof and to the uses thereof in medical imaging and/or in therapy, in particular in interventional radiology. The present invention also relates to a novel process for preparing the ligands according to the invention, and also to the preparation intermediates thereof. In which formula (I) Y
1 , Y
2 and Y
3 are independently a -C(O)OH group or a group of formula (II), at least one of the radicals Y
1 , Y
2 and Y
3 being a group of formula (II).-
公开(公告)号：EP3909948A1
公开(公告)日：2021-11-17
申请号：EP21176589.6
申请日：2015-12-04
IPC分类号： C07D401/06 , C07F9/94 , C07F7/24 , A61P39/04 , A61K51/00
摘要： The present invention relates to chelates resulting from the complexation of bifunctional do2pa derivatives ligands of formula (I), wherein the substituents R 1 , R 1' , R 2 , R 2' , R 3 , R 3' , L 1 , L 1' , L 2 and L 2' are defined as in the claims, with metallic cations, especially Pb(II) and Bi(III). The invention further relates to bifunctional do2pa derivatives ligands of formula (I). Another object of the invention is the use of chelates of the invention in nuclear medicine and the use of ligands of the invention in cations detection or epuration of effluents.
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公开(公告)号：EP3774803A1
公开(公告)日：2021-02-17
申请号：EP19713809.2
申请日：2019-03-29
申请人： Centre national de la recherche scientifique , Ecole Normale Supérieure de Lyon , UNIVERSITE CLAUDE BERNARD - LYON 1 , Université de Bretagne Occidentale
IPC分类号： C07D471/08 , A61K31/439
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6.发明公开BIFUNCTIONAL do2pa DERIVATIVES, CHELATES WITH METALLIC CATIONS AND USE THEREOF 审中-公开双金属衍生物，与金属阳离子螯合物及其用途
公开(公告)号：EP3227272A1
公开(公告)日：2017-10-11
申请号：EP15807634.9
申请日：2015-12-04
IPC分类号： C07D401/06 , C07F9/94 , C07F7/24 , A61P39/04 , A61K51/00
CPC分类号： A61K51/1093 , A61K47/6803 , A61K2123/00 , C07D213/79 , C07D257/02 , C07D401/06 , C07F7/24 , C07F9/6524 , C07F9/94
摘要： The present invention relates to chelates resulting from the complexation of bifunctional do2pa derivatives ligands of formula (I), wherein the substituents R 1 , R 1' , R 2 , R 2' , R 3 , R 3' , L 1 , L 1' L 2 and L 2' are defined as in the claims, with metallic cations, especially Pb(II) and Bi(III). The invention further relates to bifunctional do2pa derivatives ligands of formula (I). Another object of the invention is the use of chelates of the invention in nuclear medicine and the use of ligands of the invention in cations detection or epuration of effluents.
摘要翻译： 本发明涉及由式（I）的双官能团2-取代衍生物配体络合得到的螯合物，其中取代基R 1，R 1'，R 2，R 2'，R 3，R 3'，L 1，L 1 '，L 2和L 2'如权利要求中所定义，具有金属阳离子，特别是Pb（II）和Bi（III）。 本发明进一步涉及式（I）的双官能团十二烷衍生物配体。 本发明的另一个目的是本发明的螯合物在核医学中的用途以及本发明的配体在流出物的阳离子检测或环氧化中的用途。
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7.发明公开CHÉLATES DU PLOMB (II) ET DU BISMUTH (III) À BASE DE TÉTRAAZACYCLOALCANES TRANS-DI-N- PICOLINATES 审中-公开基督教信仰委员会（III）基督教信仰委员会第二十二届会议（二）
公开(公告)号：EP3004075A1
公开(公告)日：2016-04-13
申请号：EP14727858.4
申请日：2014-06-05
IPC分类号： C07D401/06 , C07F7/24 , A61K51/00 , C07F9/94 , A61P39/04
CPC分类号： C07F9/94 , A61K47/68 , A61K51/0482 , C07D401/06 , C07F7/24 , C07K16/00
摘要： The invention relates to a chelate resulting from the complexing of a trans-di-N-picolinate tetraazacycloalkane ligand with a metal cation, said ligand corresponding to formula (A) wherein n is equal to 0 or to 1, R is H or a C1-C18 alkyl radical, and R' is H or a C1-C18 alkyl radical, said metal cation being a cation of a metal selected from the group consisting of lead (II) and bismuth (III). The invention is applicable in the field of lead trapping and alpha-radioimmunotherapy.
摘要翻译： 本发明涉及由反式 - 二-N-吡啶甲酸酯四氮杂环烷配体与金属阳离子络合而形成的螯合物，所述配体对应于式（A），其中n等于0或1，R为H或C1 -C 18烷基，R'是H或C 1 -C 18烷基，所述金属阳离子是选自由铅（II）和铋（III）组成的组的金属的阳离子。 本发明适用于铅诱捕和α-放射免疫治疗领域。
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