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1.发明公开
公开(公告)号：EP1658276A1
公开(公告)日：2006-05-24
申请号：EP04739041.4
申请日：2004-08-18
申请人： H. LUNDBECK A/S
发明人： BANG-ANDERSEN, Benny , BOGES , Klaus, Peter , JENSEN, Klaus, Gjervig , SVANE, Henrik , DAHL, Allan, Carsten , HOWELLS, Mark , LYNGSO , Lars, Ole , MOW, Tomas
IPC分类号： C07D295/06 , C12P7/02 , C12P41/00 , A61K31/495 , A61P25/18
CPC分类号： C07D295/073 , C07B2200/07 , C07C17/16 , C07C25/22 , C07C29/143 , C07C35/32 , C07C2602/08 , C07D241/04 , C12P7/22 , C12P41/004 , C07C35/52
摘要： A compound 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-2,2-dimethylpiperazine and salts thereof, pharmaceutical compositions comprising the compound and salts, and medical use thereof, including for treatment of schizophrenia and other psychotic disorders.
摘要翻译： 化合物4 - （（1R，3S）-6-氯-3-苯基茚基-1-基）-2,2-二甲基哌嗪及其盐，包含该化合物和盐的药物组合物及其医疗用途，包括用于治疗 精神分裂症等精神障碍。
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2.发明授权
公开(公告)号：EP1658276B1
公开(公告)日：2012-10-10
申请号：EP04739041.4
申请日：2004-08-18
申请人： H. Lundbeck A/S
发明人： BANG-ANDERSEN, Benny , BØGESØ , Klaus, Peter , JENSEN, Klaus, Gjervig , SVANE, Henrik , DAHL, Allan, Carsten , HOWELLS, Mark , LYNGSØ , Lars, Ole , MOW, Tomas
IPC分类号： C07D295/06 , C12P7/02 , C12P41/00 , A61K31/495 , A61P25/18
CPC分类号： C07D295/073 , C07B2200/07 , C07C17/16 , C07C25/22 , C07C29/143 , C07C35/32 , C07C2602/08 , C07D241/04 , C12P7/22 , C12P41/004 , C07C35/52
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3.发明公开SUCCINATE AND MALONATE SALT OF TRANS-4-(IR,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-1,2,2-TRIMETHYLPIPERAZINE AND THE USE AS A MEDICAMENT 有权琥珀酸盐和反式-4-（1R，3S）-6-氯-3-苯基茚满-1-基）-1,2,2-三甲基哌嗪丙二酸盐和作为药物的用途
公开(公告)号：EP1658277A1
公开(公告)日：2006-05-24
申请号：EP04762772.4
申请日：2004-08-18
申请人： H. LUNDBECK A/S
发明人： LOPEZ DE DIEGO, Heidi , NIELSEN, Ole , RINGGARD, Lone, Munch , SVANE, Henrik , DAHL, Allan, Carsten , HOWELLS, Mark , BANG-ANDERSEN, Benny , LYNGSO, Lars Ole
IPC分类号： C07D295/06 , C07C35/32 , C07C25/22 , C12P7/02 , C12P41/00 , A61K31/495 , A61P25/18
CPC分类号： C07D295/073 , C07B2200/07 , C07C17/16 , C07C25/22 , C07C29/143 , C07C35/32 , C07C2602/08 , C07D241/04 , C12P7/22 , C12P41/004 , C07C35/52
摘要： 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen succinate or hadrogen malonat, pharmaceutical compositions containing these salts and the medical use thereof, including for the treatment of schizophrenia and other psychotic disorders. Also described are methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and medical uses thereof.
摘要翻译： 的化合物，4 - （（1R，3S）-6-氯-3-苯基-1-基）-2,2-二甲基哌嗪和包含该化合物和它的盐，和医药用途，包括用于治疗的盐，药物组合物 精神分裂症和其它精神障碍。
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公开(公告)号：EP1159274A2
公开(公告)日：2001-12-05
申请号：EP99968622.3
申请日：1999-11-22
申请人： H. Lundbeck A/S
IPC分类号： C07D307/87
CPC分类号： C07D307/87 , C07D307/81
摘要： Preparation of citalopram (I) or its salt comprises reacting a isobenzofuran compound (IV) with (i) a cyanide source in the presence of a palladium catalyst and a catalytic amount of copper I or zinc II ions; or (ii) with zinc cyanide in the presence of a palladium catalyst; and isolating (I). - Preparation of citalopram of formula (I) comprises reacting an isobenzofuran compound of formula (IV) with (i) a cyanide source in the presence of a palladium catalyst and a catalytic amount of copper I or zinc II ions; or (ii) with zinc cyanide in the presence of a palladium catalyst; and isolating (I). - R = halo or CF3(CF2)nSO2; - n = 0-8. - An INDEPENDENT CLAIM is also included for (IV; R = CF3(CF2)nSO2 or iodo).
摘要翻译： 包括使式（IV）化合物（其中R为卤素或CF 3 - （CF 2）n -SO 2 - ，n为0至8）与氰化物源在钯催化剂存在下反应的方法，以及 催化量的Cu 2+或Zn 2+，或与Zn（CN）2 在钯催化剂存在下进行。
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5.发明授权SUCCINATE AND MALONATE SALT OF TRANS-4-(IR,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-1,2,2-TRIMETHYLPIPERAZINE AND THE USE AS A MEDICAMENT 有权琥珀酸盐和反式-4-（1R，3S）-6-氯-3-苯基茚满-1-基）-1,2,2-三甲基哌嗪丙二酸盐和作为药物的用途
公开(公告)号：EP1658277B1
公开(公告)日：2012-04-04
申请号：EP04762772.4
申请日：2004-08-18
申请人： H. Lundbeck A/S
发明人： LOPEZ DE DIEGO, Heidi , NIELSEN, Ole , RINGGARD, Lone, Munch , SVANE, Henrik , DAHL, Allan, Carsten , HOWELLS, Mark , BANG-ANDERSEN, Benny , LYNGSO, Lars Ole
IPC分类号： C07D241/04 , C07C17/16 , C12P7/22 , C07C25/22 , C07C35/32 , C12P41/00 , A61K31/495 , A61P25/18 , C07C29/143
CPC分类号： C07D295/073 , C07B2200/07 , C07C17/16 , C07C25/22 , C07C29/143 , C07C35/32 , C07C2602/08 , C07D241/04 , C12P7/22 , C12P41/004 , C07C35/52
摘要： 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen succinate or hadrogen malonat, pharmaceutical compositions containing these salts and the medical use thereof, including for the treatment of schizophrenia and other psychotic disorders. Also described are methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and medical uses thereof.
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公开(公告)号：EP1159274B1
公开(公告)日：2003-03-26
申请号：EP99968622.3
申请日：1999-11-22
申请人： H. Lundbeck A/S
IPC分类号： C07D307/87
CPC分类号： C07D307/87 , C07D307/81
摘要： Preparation of citalopram (I) or its salt comprises reacting a isobenzofuran compound (IV) with (i) a cyanide source in the presence of a palladium catalyst and a catalytic amount of copper I or zinc II ions; or (ii) with zinc cyanide in the presence of a palladium catalyst; and isolating (I). - Preparation of citalopram of formula (I) comprises reacting an isobenzofuran compound of formula (IV) with (i) a cyanide source in the presence of a palladium catalyst and a catalytic amount of copper I or zinc II ions; or (ii) with zinc cyanide in the presence of a palladium catalyst; and isolating (I). - R = halo or CF3(CF2)nSO2; - n = 0-8. - An INDEPENDENT CLAIM is also included for (IV; R = CF3(CF2)nSO2 or iodo).
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