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    VERFAHREN ZUR BESTIMMUNG DES ENZYMATISCHEN STATUS HUMANER HAUT IN VITRO
    2.
    发明公开
    VERFAHREN ZUR BESTIMMUNG DES ENZYMATISCHEN STATUS HUMANER HAUT IN VITRO 审中-公开
    程序对决定人类皮肤的体外酶促状态

    公开(公告)号：EP1573042A1

    公开(公告)日：2005-09-14

    申请号：EP03782279.8

    申请日：2003-12-02

    申请人： Henkel Kommanditgesellschaft auf Aktien

    发明人： WIELAND, Susanne ,  SPITZ, Astrid ,  MERKEL, Marion ,  SIEGERT, Petra

    IPC分类号： C12Q1/00 ,  C12Q1/02

    CPC分类号： C12Q1/025

    摘要： The invention relates to a method for determining the enzymatic status of human skin in vitro, to test kits for determining the enzymatic status of human skin in vitro and to the use of enzymes for determining the enzymatic status of human skin. The invention also relates to a test method for establishing the activity of cosmetic or pharmaceutical substances for treating human skin, to a screening method for identifying cosmetic and pharmaceutical substances for treating human skin and to a method for producing a cosmetic or pharmaceutical preparation for treating human skin.

    SUBTILISIN-VARIANTEN, BEI DENEN DIE PERHYDROLASE-AKTIVITÄT ERHÖHT WURDE
    3.
    发明公开
    SUBTILISIN-VARIANTEN, BEI DENEN DIE PERHYDROLASE-AKTIVITÄT ERHÖHT WURDE 审中-公开
    变异枯草杆菌该活动INCREASES过水解BEEN

    公开(公告)号：EP1572997A1

    公开(公告)日：2005-09-14

    申请号：EP03785804.0

    申请日：2003-12-12

    申请人： Henkel Kommanditgesellschaft auf Aktien

    发明人： WIELAND, Susanne ,  POLANYI-BALD, Laura ,  PRÜSER, Inken ,  STEHR, Regina ,  MAURER, Karl-Heinz

    IPC分类号： C12N9/56

    CPC分类号： C11D3/38636 ,  C12N9/54

    摘要： The invention relates to novel perhydrolases, derived from the protease Carlsberg by amino acid exchange in positions 11, 15, 21, 38, 50, 54, 58, 77, 83, 89, 93, 96, 107, 117, 120, 134, 135, 136, 140, 147, 150, 154, 155, 160, 161, 171, 179, 180, 181, 194, 205, 208, 213, 216, 217, 238, 239, 251, 253, 257 and/or 261. The invention further relates to methods for production of said novel perhydrolases, means, in particular bodycare, haircare, shampoo, hair-dyeing, hair-bleaching, oral-care, dental-care, dental-prosthesis-care, cosmetic, therapeutic, (textile) washing, cleaning, rinsing, handwash, washing-up and dish-washing means, comprising said novel perhydrolases and corresponding applications of said novel perhydrolases.

    GEGEN DI- UND/ODER MULTIMERISIERUNG STABILISIERTE ALPHA-AMYLASE-VARIANTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE WASCH- UND REINIGUNGSMITTEL MIT DIESEN ALPHA-AMYLASE-VARIANTEN
    4.
    发明公开
    GEGEN DI- UND/ODER MULTIMERISIERUNG STABILISIERTE ALPHA-AMYLASE-VARIANTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE WASCH- UND REINIGUNGSMITTEL MIT DIESEN ALPHA-AMYLASE-VARIANTEN 有权
    反对二和/或多聚稳定化的α-淀粉酶变，生产和洗涤方法与这些α淀粉酶的变体清洁

    公开(公告)号：EP1794292A2

    公开(公告)日：2007-06-13

    申请号：EP05788794.5

    申请日：2005-09-22

    申请人： HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN

    发明人： BESSLER, Cornelius ,  WIELAND, Susanne ,  MAURER, Karl-Heinz

    IPC分类号： C12N9/28 ,  C11D3/386

    CPC分类号： C12N9/2417 ,  C11D3/38681

    摘要： The invention relates to α-amylase variants, which are stabilized with regard to dimerization and/or multimerization by the point mutagenesis of positively polarized or charged or neutral surface amino acids into negatively polarized or charged amino acids. The invention also relates to methods for increasing the stability of an α-amylase with regard to a dimerization and/or multimerization induced by electrostatic interactions, whereby at least one amino acid radical of the starting molecule, which is located on the surface of the molecule and which exerts a neutral or positively polar or charged contribution to the electrostatic potential of the molecule, is replaced by a stronger negatively polar or negatively charged amino acid radical. The α-amylase variants obtained in this manner exhibit an improved processivity and are suited for numerous technical areas of application, particularly for use as active ingredients in detergents and cleansers.

    NEUE ALKALISCHE PROTEASEN UND WASCH- UND REINIGUNGSMITTEL, ENTHALTEND DIESE NEUEN ALKALISCHEN PROTEASEN
    7.
    发明公开
    NEUE ALKALISCHE PROTEASEN UND WASCH- UND REINIGUNGSMITTEL, ENTHALTEND DIESE NEUEN ALKALISCHEN PROTEASEN 有权
    NEUE ALKALISCHE PROTEASEN UND WASCH- UND REINIGUNGSMITTEL，ENTHALTEND DIESE NEUEN ALKALISCHEN PROTEASEN

    公开(公告)号：EP1737952A1

    公开(公告)日：2007-01-03

    申请号：EP05738142.8

    申请日：2005-04-15

    申请人： Henkel Kommanditgesellschaft auf Aktien

    发明人： WIELAND, Susanne ,  MAURER, Karl-Heinz ,  KOTTWITZ, Beatrix ,  NIEHAUS, Frank ,  LORENZ, Patrick

    IPC分类号： C12N9/52 ,  C12N15/57 ,  C11D3/386

    CPC分类号： C12N9/52 ,  C11D3/38609 ,  C11D3/38618

    摘要： The invention relates to two similar novel alkaline proteases (SEQ ID NO. 4 and 7) whose DNA have been obtained from samples of soil as well as C-terminal deleted, also proteolytically active fragments thereof (SEQ ID NO. 5 and 8), all alkaline proteases that are similar by at least 90 percent to SEQ ID NO. 4 or by 87.5 percent to SEQ ID NO. 7, and those which can be combined under a consensus sequence (SEQ ID NO. 9) derived from SEQ ID NO. 4 and 7. The invention further relates to all nucleic acids that have at least 85 percent identity to the associated nucleic acids (SEQ ID NO. 3 and 6) or the respective fragments. The invention also relates to possible technical uses of said proteases and above all the use thereof in detergents and cleaners.

    摘要翻译： 本发明涉及两种类似的新型碱性蛋白酶（SEQ ID NO.4和7），其DNA已经从土壤样品以及C末端缺失的，也有其蛋白水解活性片段（SEQ ID NO.5和8）获得， 所有碱性蛋白酶与SEQ ID NO.1具有至少90％的相似性。 4或87.5％与SEQ ID NO.1有关。 7和可以在来自SEQ ID NO.9的共有序列（SEQ ID NO.9）下组合的那些。 本发明进一步涉及与相关核酸（SEQ ID NO.3和6）或各个片段具有至少85％同一性的所有核酸。 本发明还涉及所述蛋白酶的可能的技术用途，并且最重要的是其在洗涤剂和清洁剂中的用途。

    ALPHA-AMYLASE-VARIANTEN MIT ERHÖHTER LÖSUNGSMITTELSTABILITÄT, VERFAHREN ZU DEREN HERSTELLUNG SOWIE WASCH- UND REINIGUNGSMITTEL MIT DIESEN ALPHA-AMYLASE-VARIANTEN
    10.
    发明公开
    ALPHA-AMYLASE-VARIANTEN MIT ERHÖHTER LÖSUNGSMITTELSTABILITÄT, VERFAHREN ZU DEREN HERSTELLUNG SOWIE WASCH- UND REINIGUNGSMITTEL MIT DIESEN ALPHA-AMYLASE-VARIANTEN 有权
    α-淀粉酶变具有增加的溶剂稳定性，生产和洗涤方法与这些α淀粉酶的变体清洁

    公开(公告)号：EP1794293A2

    公开(公告)日：2007-06-13

    申请号：EP05796115.3

    申请日：2005-09-22

    申请人： HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN

    发明人： BESSLER, Cornelius ,  WIELAND, Susanne ,  MAURER, Karl-Heinz

    IPC分类号： C12N9/28 ,  C11D3/386

    CPC分类号： C11D3/38681 ,  C12N9/2417

    摘要： The invention relates to α-amylase variants that are stabilized by the point mutagenesis of asparagine (N-) radicals or glutamine (Q-) radicals, these radicals being located on the surface of the molecule, to form other amino acids with regard to a hydrolysis performed via the solvent, in particular, at elevated temperatures or high pH values. The invention also relates to methods for increasing the stability of an α-amylase with regard to a hydrolysis performed via the solvent, in particular, at elevated temperatures or high pH values, whereby at least one asparagine (N-) radical or glutamine (Q-) radical located on the surface of the molecule is exchanged to form another amino acid radical. The α-amylase variants obtained in this manner exhibit a better stability with regard to influences by solvents, an increased processivity and are suited for numerous technical areas of application, particularly for use as active ingredients in detergents and cleansers.