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公开(公告)号：EP0619116A3
公开(公告)日：1994-11-23
申请号：EP94105021.3
申请日：1994-03-30
发明人： Shudo, Koichi , Sugioka, Tatsuo , Inazu, Mizuho , Tanaka, Hideyuki , Inoue, Tsutomu , Kitamura, Kazuyuki
CPC分类号： A61K31/655 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/336 , A61K31/35 , A61K31/352 , A61K31/44
摘要： An anti-osteopathic composition comprising as an active ingredient a compound represented by the following formula (I), (II) or (III):
which is useful for therapeutic and prophylactic treatment of osteopathia such as osteoporosis and bone fracture.-
公开(公告)号：EP0619116A2
公开(公告)日：1994-10-12
申请号：EP94105021.3
申请日：1994-03-30
发明人： Shudo, Koichi , Sugioka, Tatsuo , Inazu, Mizuho , Tanaka, Hideyuki , Inoue, Tsutomu , Kitamura, Kazuyuki
CPC分类号： A61K31/655 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/336 , A61K31/35 , A61K31/352 , A61K31/44
摘要： An anti-osteopathic composition comprising as an active ingredient a compound represented by the following formula (I), (II) or (III):
which is useful for therapeutic and prophylactic treatment of osteopathia such as osteoporosis and bone fracture.摘要翻译： 一种抗骨质疏松组合物，其包含作为活性成分的由下式（I），（II）或（III）表示的化合物：
，其可用于治疗和预防性治疗骨质疏松症（例如骨质疏松症和骨折）。 -
公开(公告)号：EP0677289A3
公开(公告)日：1996-10-23
申请号：EP95105177.0
申请日：1995-04-06
发明人： Tobe, Hiroyasu , Kitamura, Kazuyuki
IPC分类号： A61K31/12
CPC分类号： A61K31/12 , A61K2300/00
摘要： A pharmaceutical composition for treating osteoporosis which comprises as an active ingredient an effective amount of one or more compounds selected from the group comprising humulone, cohumulone, adhumulone, isohumulone, isocohumulone and isoadhumulone in combination with a pharmaceutically acceptable carrier or excipient. Humulone, cohumulone, adhumulone are the compounds belonging to α acids which are an ingredient extracted from hops, whilst isohumulone, isocohumulone and isoadhumulone are the compounds belonging to iso α acid derivatives which are isomers of α acids. The above described compounds have a bone resorption inhibiting activity and are useful for treating osteoporosis.
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4.发明公开Pharmaceutical composition for treating osteoporosis containing xanthohumol 失效Pharmazutische Zusammensetzung zur Behandlung von Osteoporose enthaltend Xanthohumol。
公开(公告)号：EP0679393A2
公开(公告)日：1995-11-02
申请号：EP95105766.0
申请日：1995-04-18
IPC分类号： A61K31/12
CPC分类号： A61K31/12
摘要： A therapeutic agent for osteoporosis comprising as an active ingredient xanthohumol. Xanthohumol obtained from hop extracts has a bone resorption inhibiting activity and is useful as a therapeutic agent for osteoporosis.
摘要翻译： 一种用于骨质疏松症的治疗剂，其包含作为活性成分的黄腐酚。 从啤酒花提取物获得的黄单胞菌素具有骨吸收抑制活性，可用作骨质疏松症的治疗剂。
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5.发明公开Tissue antigen and diagnostic method for human osteoporosis using the same 失效使用该组织的人体骨质疏松症的组织抗原和诊断方法
公开(公告)号：EP0561297A3
公开(公告)日：1994-10-26
申请号：EP93104062.0
申请日：1993-03-12
IPC分类号： C07K15/06 , G01N33/68 , C12P21/08 , A61K39/395 , G01N33/577
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28
摘要： An animal tissue antigen for osteoporotic patients that reacts with antibody in a serum of human osteoporotic patients, but does not react with that in normal human serum. Preferably, a specific antigen for osteoporotic patients in rat or mouse epithelium of tongue mucous membrane, epithelium of tracheal mucous membrane, upper lip epidermis or follicular epithelium containing upper lip hair shafts, or a specific antigen for osteoporotic patients contained in cultured cells of a human squamous cell tongue carcinoma cell lines such as SCC-9 and fibroblast cell lines such as MRC-5. Osteoporosis can be both specifically and easily diagnosed by bringing the above-mentioned antigen in contact with the serum of a subject and then testing for the presence of an antigen-antibody reaction.
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6.发明授权
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公开(公告)号：EP0687470A3
公开(公告)日：1996-06-19
申请号：EP95109011.7
申请日：1995-06-12
IPC分类号： A61K38/17
CPC分类号： A61K38/1793
摘要： A pharmaceutical composition for treating metabolic bone diseases which comprises as an active ingredient IL-1 receptor, a soluble fragment consisting of an extracellular domain of IL-1R or a fragment thereof derived from mammals. The composition has a bone resorption inhibiting activity and is useful for the therapy and prophylaxis of metabolic bone diseases.
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8.发明公开Pharmaceutical composition for treating osteoporosis 失效Arzneimittel zur Behandlung von Osteoporose。
公开(公告)号：EP0677289A2
公开(公告)日：1995-10-18
申请号：EP95105177.0
申请日：1995-04-06
发明人： Tobe, Hiroyasu , Kitamura, Kazuyuki
IPC分类号： A61K31/12
CPC分类号： A61K31/12 , A61K2300/00
摘要： A pharmaceutical composition for treating osteoporosis which comprises as an active ingredient an effective amount of one or more compounds selected from the group comprising humulone, cohumulone, adhumulone, isohumulone, isocohumulone and isoadhumulone in combination with a pharmaceutically acceptable carrier or excipient. Humulone, cohumulone, adhumulone are the compounds belonging to α acids which are an ingredient extracted from hops, whilst isohumulone, isocohumulone and isoadhumulone are the compounds belonging to iso α acid derivatives which are isomers of α acids.
The above described compounds have a bone resorption inhibiting activity and are useful for treating osteoporosis.摘要翻译： 一种用于治疗骨质疏松症的药物组合物，其包含与药学上可接受的载体或赋形剂组合的有效量的一种或多种选自包含葎草酮，共聚葎草酮，异葎草酮，异葎草酮，异葎草酮和异葎草酮的化合物的活性成分。 葎草酮，共葎草酮，异葎草酮是属于从啤酒花提取的成分的α-酸的化合物，而异葎草酮，异葎草酮和异葎草酮是属于α-酸的异构体的异α酸衍生物的化合物。 上述化合物具有骨吸收抑制活性，可用于治疗骨质疏松症。
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9.发明公开Pharmaceutical composition for treating osteoporosis containing xanthohumol 失效用于治疗包含黄腐酚的骨质疏松症的药物组合物
公开(公告)号：EP0679393A3
公开(公告)日：1995-11-15
申请号：EP95105766.0
申请日：1995-04-18
IPC分类号： A61K31/12
CPC分类号： A61K31/12
摘要： A therapeutic agent for osteoporosis comprising as an active ingredient xanthohumol. Xanthohumol obtained from hop extracts has a bone resorption inhibiting activity and is useful as a therapeutic agent for osteoporosis.
摘要翻译： 一种骨质疏松症治疗剂，其中含有黄腐酚作为活性成分。 由啤酒花提取物得到的黄腐酚具有骨吸收抑制活性，可用作骨质疏松症的治疗剂。
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10.发明公开
公开(公告)号：EP0687470A2
公开(公告)日：1995-12-20
申请号：EP95109011.7
申请日：1995-06-12
IPC分类号： A61K38/17
CPC分类号： A61K38/1793
摘要： A pharmaceutical composition for treating metabolic bone diseases which comprises as an active ingredient IL-1 receptor, a soluble fragment consisting of an extracellular domain of IL-1R or a fragment thereof derived from mammals.
The composition has a bone resorption inhibiting activity and is useful for the therapy and prophylaxis of metabolic bone diseases.摘要翻译： 一种用于治疗代谢性骨疾病的药物组合物，其包含IL-1受体的活性成分，由IL-1R的细胞外结构域或其衍生自哺乳动物的片段组成的可溶性片段。 该组合物具有骨吸收抑制活性，可用于治疗和预防代谢性骨病。
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