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1.发明授权METHOD FOR PREPARING A SITE-SPECIFIC CONJUGATE OF A PHYSIOLOGICALLY ACTIVE POLYPEPTIDE 有权PROCEDURE FOR A局部特定的制备共轭生理活性多肽
公开(公告)号：EP2408800B1
公开(公告)日：2016-05-25
申请号：EP10753706.0
申请日：2010-03-18
发明人： SONG, Dae Hae , SHIN, Jae Hee , LEE, Jae Min , PARK, Young Kyung , KWON, Se Chang , LEE, Gwan Sun
CPC分类号： C07K1/1077 , A61K47/60 , C07K14/575 , C07K14/605 , C07K14/62
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公开(公告)号：EP2552474B1
公开(公告)日：2017-02-22
申请号：EP11763093.9
申请日：2011-04-04
发明人： SONG, Dae Hae , SHIN, Jae Hee , PARK, Young Jin , IM, Dae Seong , BAE, Sung Min , KWON, Se Chang
CPC分类号： A61K38/28 , A61K47/68 , A61K47/6883 , C07K14/62 , C07K2319/30
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3.发明授权A POLYPEPTIDE COMPLEX COMPRISING NON-PEPTIDYL POLYMER HAVING THREE FUNCTIONAL ENDS 有权与三个功能结束的非肽基聚合物多肽复合
公开(公告)号：EP2300501B1
公开(公告)日：2014-08-20
申请号：EP09800577.0
申请日：2009-07-23
发明人： SONG, Dae Hae , SHIN, Jae Hee , LEE, Mi Ji , HONG, Sung Hee , KWON, Se Chang , LEE, Gwan Sun
CPC分类号： A61K47/48715 , A61K47/60 , A61K47/6811 , A61K47/6889 , C07K14/59 , C07K19/00 , C07K2319/31
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公开(公告)号：EP2552474A2
公开(公告)日：2013-02-06
申请号：EP11763093.9
申请日：2011-04-04
发明人： SONG, Dae Hae , SHIN, Jae Hee , PARK, Young Jin , IM, Dae Seong , BAE, Sung Min , KWON, Se Chang
CPC分类号： A61K38/28 , A61K47/68 , A61K47/6883 , C07K14/62 , C07K2319/30
摘要： The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
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