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公开(公告)号：EP3416676A1
公开(公告)日：2018-12-26
申请号：EP17750587.2
申请日：2017-02-01
申请人： Adepthera LLC
发明人： HSU, Sheau Yu Teddy
IPC分类号： A61K38/22 , C07K14/575 , C07K16/28
CPC分类号： A61K38/22 , A61K31/704 , A61K38/225 , A61K45/06 , C07K14/575 , A61K2300/00
摘要： Long-acting agonistic analogs for CLR/RAMP receptors are provided that have an extended half-live in vivo. The agonists are delivered to an individual at a dose sufficient to reduce hypertension and ischemic injury, and to reduce cardiotoxicity associated with chemotherapeutic agents.
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公开(公告)号：EP3394091A2
公开(公告)日：2018-10-31
申请号：EP16873641.1
申请日：2016-12-05
发明人： PALANI, Anandan , CARRINGTON, Paul, E. , PESSI, Antonello , LAHM, Armin , BIANCHI, Elisabetta , DEMARTIS, Anna
IPC分类号： C07K14/605 , C07K14/575 , C07K14/435
CPC分类号： A61K38/16 , A61K38/00 , A61P1/16 , A61P3/10 , C07K14/575
摘要： Co-agonists of the glucagon and GLP-1 receptors are described.
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4.发明公开
公开(公告)号：EP3351629A1
公开(公告)日：2018-07-25
申请号：EP16846543.3
申请日：2016-09-14
发明人： AIZAWA Yasunori , KITANO Shohei , KIDA Yuichiro
IPC分类号： C12N15/09 , A01K67/027 , C07K14/47 , C07K14/575 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/02 , C12Q1/68 , C12P21/08
CPC分类号： A01K67/027 , C07K14/47 , C07K14/575 , C07K16/26 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/68
摘要： An object of the present invention is to provide a method for identifying a physiologically active protein translated from an ORF other than mORF present on mRNA.
The object can be solved by a method for identifying a physiologically active protein, wherein an ORF which encodes a protein having a physiological activity, other than a main open reading frame (ORF) is identified in eukaryotic mRNA, comprising the steps of: (1) introducing an expression vector incorporating a candidate ORF to cells, and culturing the introduced cells, (2) detecting a protein bound to a candidate protein by immunoprecipitating the candidate protein translated from the candidate ORF, from the cultured cells, (3) determining a candidate protein in which another protein bound to the candidate protein is detected as a physiologically active protein.-
公开(公告)号：EP3240564A4
公开(公告)日：2018-05-30
申请号：EP15867141
申请日：2015-12-10
申请人： OPKO BIOLOGICS LTD
CPC分类号： C07K14/59 , A61K38/00 , C07K14/505 , C07K14/555 , C07K14/575 , C07K14/61 , C07K2319/00 , C07K2319/31 , C12N9/6437 , C12N9/644 , C12N15/85 , C12Y304/21021 , C12Y304/21022
摘要： Disclosed herein is a method for manufacturing a recombinant human growth hormone (h GH) modified by a CTP extension in a mammalian cells culture system.
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公开(公告)号：EP2308889B1
公开(公告)日：2018-05-23
申请号：EP10187879.1
申请日：2004-06-02
发明人： Pan, Shuchong , Simari, Robert D.
CPC分类号： C07K14/575 , A61K38/00 , C07K14/58 , C07K16/26 , G01N2333/58 , G01N2800/325
摘要： Methods and materials for diagnosing and treating heart conditions (e.g., heart failure) and kidney conditions (e.g., kidney failure) are described.
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公开(公告)号：EP3310376A1
公开(公告)日：2018-04-25
申请号：EP16812418.8
申请日：2016-06-16
发明人： SHEN, Weijun , YANG, Pengyu , SCHULTZ, Peter G.
CPC分类号： A61K31/20 , A61K9/0021 , A61K31/23 , A61K38/13 , A61K38/2264 , A61K38/26 , A61K38/28 , A61K47/542 , A61K47/554 , C07K14/575 , C07K14/57563 , C07K14/605 , A61K2300/00
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
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公开(公告)号：EP3161164A4
公开(公告)日：2018-04-25
申请号：EP15812513
申请日：2015-06-29
IPC分类号： C12Q1/68 , A61K38/00 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention provides novel hepcidin analogues, and related methods of using these hepcidin analogues to treat or prevent a variety of diseases and disorders, including iron overload diseases such as hereditary hemochromatosis, iron-loading anemias, and other conditions and disorders described herein.
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公开(公告)号：EP2839010B1
公开(公告)日：2018-04-25
申请号：EP13765199.8
申请日：2013-03-19
发明人： BASTIRAS, Stan , GUIDOLIN, Angelo , HUNT, Ben , RAISHEED, Saif , ZAREIE, Reza
IPC分类号： C12P21/06 , C12N15/62 , C07K14/575
CPC分类号： C07K14/575 , C07K2319/00 , C07K2319/50 , C12N15/62 , C12P21/06
摘要： Methods of producing a recombinant peptide, such as vessel dilator peptide (VSDL), are disclosed, including a particular method involving expressing a fusion polypeptide comprising concatemeric repeats of the peptide wherein the peptide is flanked by peptide cleavage sites, and cleaving the fusion polypeptide at the peptide cleavage sites with a cleaving agent(s) so as to release the peptide from the fusion polypeptide. Expression constructs and host cells for producing the fusion polypeptide and purification methods for the recombinant peptide are also disclosed.
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公开(公告)号：EP3307768A1
公开(公告)日：2018-04-18
申请号：EP16734567.7
申请日：2016-06-13
申请人： Novo Nordisk A/S
IPC分类号： C07K14/575 , A61K38/22 , A61K47/48 , A61P3/04
CPC分类号： C07K14/47 , A61K38/00 , A61K47/542 , C07K14/575
摘要： The invention relates to PYY compounds with the amino acid modifications 7Lys, 30Trp, and 31Leu, and in addition to these, 22Ile and/or 28Tyr, and derivatives thereof. The compounds of the invention are selective Y2 receptor agonists. The invention also relates to pharmaceutical compositions comprising such PYY compounds and pharmaceutically acceptable excipients, as well as the medical use of the PYY compounds.
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