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1.发明公开EXPRESSION OF XENOGENOUS (HUMAN) IMMUNOGLOBULINS IN CLONED, TRANSGENIC UNGULATES 有权在克隆，转基因牛表达异种（人）免疫球蛋白
公开(公告)号：EP1343880A2
公开(公告)日：2003-09-17
申请号：EP01273248.3
申请日：2001-11-16
发明人： ROBL, James, M. , GOLDSBY, Richard, A. , FERGUSON, Stacy, E. , KUROIWA, Yoshimi , TOMIZUKA, Kazuma , ISHIDA, Isao
IPC分类号： C12N15/00 , C12P21/00 , A01K67/033 , A01K67/027
CPC分类号： C12N15/8509 , A01K67/0273 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/101 , A01K2267/01 , C12N9/1051 , C12N2800/30
摘要： The present invention relates to the production of a trangenic bovine which comprises a genetic modification that resulrs in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results on the expression of non-bovine antibodies, preferably human antibodies.
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公开(公告)号：EP1749102A2
公开(公告)日：2007-02-07
申请号：EP05738421.6
申请日：2005-04-21
IPC分类号： C12P21/00 , A01K67/027 , C12N15/00 , C07K16/00
CPC分类号： A01K67/0271 , A01K67/0273 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/101 , A01K2267/01 , A01K2267/02 , A01K2267/0343 , C07K2317/00 , C07K2317/21 , C12N15/8509 , C12N15/8771
摘要： In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and method of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
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3.发明授权TRANSGENIC TRANSCHROMOSOMAL RODENTS FOR MAKING HUMAN ANTIBODIES 有权TRANSCHROMOSOMALE TRANSGEN-鼠类为制造抗体HUMÄNEN
公开(公告)号：EP1354034B1
公开(公告)日：2007-11-14
申请号：EP01987182.1
申请日：2001-11-30
发明人： TOMIZUKA, Kazuma , ISHIDA, Isao , LONBERG, Nils , HALK, Ed
IPC分类号： C12N15/00 , A01K67/027 , C12N5/06 , C07K16/00 , C12N5/20
CPC分类号： A01K67/0278 , A01K67/02 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K39/00 , A61K2039/505 , C07K14/70535 , C07K16/00 , C07K16/18 , C07K16/243 , C07K16/2812 , C07K16/2818 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/92 , C12N5/0635 , C12N5/163 , C12N15/8509 , C12N2015/8518 , C12P21/005 , C12Q1/6881 , C12Q2600/158
摘要： The present invention provides a transgenic nonhuman mammal, preferably a rodent, comprising two human immunoglobulin loci, wherein one of two said human immunoglobulin loci is a human heavy chain locus and the other locus is a human light chain locus; and wherein only one of said loci is of a transchromosome. In some transgenic nonhuman mammals, the endogenous mammalian heavy chain locus and at least one mammalian light chain locus are inactivated. In some such transgenic nonhuman mammals, the endogenous mammalian heavy chain locus and kappa light chain locus are inactivated. The present invention further provides methods of generating a plurality of B cells from a transgenic nonhuman mammal expressing human antibody sequences. Additional methods of the invention comprise fusing the plurality of B cells with immortalized cells to form hybridomas. The present invention also provides methods of generating a human sequence antibody from a transgenic nonhuman mammal.
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4.发明公开TRANSGENIC TRANSCHROMOSOMAL RODENTS FOR MAKING HUMAN ANTIBODIES 有权TRANSCHROMOSOMALE TRANSGEN-鼠类为制造抗体HUMÄNEN
公开(公告)号：EP1354034A2
公开(公告)日：2003-10-22
申请号：EP01987182.1
申请日：2001-11-30
发明人： TOMIZUKA, Kazuma , ISHIDA, Isao , LONBERG, Nils , HALK, Ed
IPC分类号： C12N15/00 , A01K67/027 , C12N5/06 , C07K16/00 , C12N5/20
CPC分类号： A01K67/0278 , A01K67/02 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K39/00 , A61K2039/505 , C07K14/70535 , C07K16/00 , C07K16/18 , C07K16/243 , C07K16/2812 , C07K16/2818 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/92 , C12N5/0635 , C12N5/163 , C12N15/8509 , C12N2015/8518 , C12P21/005 , C12Q1/6881 , C12Q2600/158
摘要： The present invention provides a transgenic nonhuman mammal, preferably a rodent, comprising two human immunoglobulin loci, wherein one of two said human immunoglobulin loci is a human heavy chain locus and the other locus is a human light chain locus; and wherein only one of said loci is of a transchromosome. In some transgenic nonhuman mammals, the endogenous mammalian heavy chain locus and at least one mammalian light chain locus are inactivated. In some such transgenic nonhuman mammals, the endogenous mammalian heavy chain locus and kappa light chain locus are inactivated. The present invention further provides methods of generating a plurality of B cells from a transgenic nonhuman mammal expressing human antibody sequences. Additional methods of the invention comprise fusing the plurality of B cells with immortalized cells to form hybridomas. The present invention also provides methods of generating a human sequence antibody from a transgenic nonhuman mammal.
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