公开(公告)号：EP4396209A1

公开(公告)日：2024-07-10

申请号：EP22865847.2

申请日：2022-09-02

申请人： Amyris, Inc.

发明人： PINEL, Dominic ,  HSIAO, Victoria ,  MARINA, Diana, Bahrani ,  ABBOTT, Derek, A.

IPC分类号： C07K14/39 ,  C12N15/09 ,  C12P19/04

CPC分类号： C07K14/39 ,  C12P19/04 ,  C12N15/81 ,  C12N15/52 ,  C12Y101/01021 ,  C12Y101/01 ,  C12N9/0004 ,  C12N9/1048 ,  C12N9/22 ,  C07K14/395 ,  C12R2001/86520210501 ,  C12Y204/01056 ,  C12Y204/01 ,  C12R2001/64520210501 ,  C12N9/0006 ,  C12Y204/01038 ,  C12N9/1241 ,  C12Y207/07023 ,  C12Y402/01047 ,  C12N9/88 ,  C12N9/1051 ,  C12Y204/01069 ,  C12Y101/01271 ,  C12P19/00 ,  C12P19/18

公开(公告)号：EP4392573A1

公开(公告)日：2024-07-03

申请号：EP22776967.6

申请日：2022-08-22

申请人： ROQUETTE FRERES

发明人： LANOS, Pierre ,  RAMETTE, Matthieu ,  REMAUD-SIMEON, Magali ,  MOULIS, Claire ,  PIZZUT-SERIN, Sandra ,  SEVERAC, Etienne

IPC分类号： C12P19/04 ,  C12P19/18 ,  A23L33/21 ,  C08B37/00 ,  C12N9/10

CPC分类号： C12P19/04 ,  C12P19/18 ,  A23L33/21 ,  C08B37/0009 ,  C12N9/1051 ,  C12Y204/01 ,  C12Y204/01005

公开(公告)号：EP4389908A2

公开(公告)日：2024-06-26

申请号：EP24171392.4

申请日：2020-08-06

申请人： GlaxoSmithKline Biologicals S.A.

发明人： IHNKEN, Leigh Anne ,  KARPIAK, Joel ,  KEMMLER, Stefan Jochen ,  KOWARIK, Michael Thomas ,  MELBY, Joel ,  OLLIS, Anne ,  QUEBATTE, Julien Laurent

IPC分类号： C12P21/00

CPC分类号： C12N9/1051 ,  C12P21/005 ,  Y02A50/30

摘要： The present disclosure provides mutated PglB oligosaccharyltransferase enzymes that have the ability to efficiently catalyze the transfer of a saccharide from a lipid carrier to an asparagine reissue in a glycosylation motif on a protein. Also provided are polynucleotides encoding the mutated PglB oligosaccharyltransferase enzymes, host cells capable of expressing the engineered PglB oligosaccharyltransferase enzymes, and methods of using the engineered PglB oligosaccharyltransferase enzymes to make N-glycosylated proteins. Also provided are N-glycosylated proteins that are made using the engineered PglB oligosaccharyltransferase enzymes.

公开(公告)号：EP4381056A1

公开(公告)日：2024-06-12

申请号：EP21763022.7

申请日：2021-08-05

申请人： Wacker Chemie AG

发明人： MARTIN, Julia ,  BORNHÖVD, Carsten

IPC分类号： C12N9/10 ,  C12N15/52 ,  C12P19/18

CPC分类号： C12N9/1051 ,  C12P19/18 ,  C12Y204/01069 ,  C12N15/52 ,  C12P19/00

公开(公告)号：EP3423034A1

公开(公告)日：2019-01-09

申请号：EP17707564.5

申请日：2017-02-28

申请人： G.L. Pharma GmbH

发明人： GÜBITZ, Georg ,  GREIMEL, Katrin ,  BRANDAUER, Martin ,  HUBER, Daniela ,  BLEYMAIER, Klaus ,  KROUTIL, Wolfgang ,  LECHNER, Doris ,  WACHTER, Christof ,  WAGNER, Harald ,  WINKLER, Heimo

IPC分类号： A61K9/06 ,  A61K47/36 ,  A61K31/00 ,  C12N9/00

CPC分类号： A61K47/42 ,  A61K9/06 ,  A61K31/485 ,  A61K47/36 ,  A61K47/61 ,  A61K47/6903 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0065 ,  C12N9/0069 ,  C12N9/0071 ,  C12N9/1025 ,  C12N9/1051 ,  C12N9/13 ,  A61K2300/00

摘要： Disclosed is an abuse-deterrent pharmaceutical composition comprising a drug with an enzyme-reactive functional group, wherein the drug has an abuse potential, and an enzyme capable of reacting with the enzyme-reactive functional group (a drug-processing enzyme), wherein the drug with the enzyme-reactive functional group is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on the drug.

公开(公告)号：EP3417054A1

公开(公告)日：2018-12-26

申请号：EP17702765.3

申请日：2017-01-18

申请人： CEVEC Pharmaceuticals GmbH

发明人： WISSING, Silke ,  WÖLFEL, Jens ,  FAUST, Nicole ,  KEWES, Helmut

IPC分类号： C12N5/10 ,  C12P21/00

CPC分类号： C12N5/00 ,  C07K14/435 ,  C12N9/1048 ,  C12N9/1051 ,  C12N2501/724 ,  C12N2510/02 ,  C12N2511/00 ,  C12P21/005 ,  C12Y204/01145 ,  C12Y204/01155 ,  C12Y204/99001 ,  C12Y204/99004

摘要： The present invention relates to a genetically modified cell line with reduced expression of GnTIVa/b and/or GnTV, a method for the production of glycoproteins having N-glycans with a reduced number of tri- and/or tetra-antennary N-glcyans using said cell line, and respective glycoproteins.

公开(公告)号：EP2971030B8

公开(公告)日：2018-12-05

申请号：EP14767544.1

申请日：2014-03-14

申请人： Glycobia, Inc ,  Fisher, Adam, C. ,  Merritt, Judith H. ,  Hamilton, Brian S. ,  Valderrama-Rinco, Juan D. ,  Delisa, Matthew P.

发明人： FISHER, Adam, C. ,  MERRITT, Judith, H. ,  HAMILTON, Brian, S. ,  VALDERRAMA-RINCON, Juan, D. ,  DELISA, Matthew, P.

IPC分类号： C12P19/18 ,  C12P21/00 ,  C12N1/21

CPC分类号： C12P19/04 ,  A61K39/0258 ,  C07K14/245 ,  C07K14/605 ,  C07K16/00 ,  C07K2317/14 ,  C07K2317/41 ,  C12N9/1051 ,  C12N9/1081 ,  C12N15/52 ,  C12N15/70 ,  C12P19/18 ,  C12P21/005 ,  C12Y204/01 ,  Y02A50/474

摘要： Disclosed are methods and compositions to produce various oligosaccharide compositions and glycoproteins. Prokaryotic hosts cells are cultured under conditions effective to produce human-like e.g., high-mannose, hybrid and complex glycosylation patterns by introducing glycosylation pathways into the host cells.

公开(公告)号：EP3060576B1

公开(公告)日：2018-09-26

申请号：EP14787180.0

申请日：2014-10-22

申请人： Bayer CropScience NV ,  Commonwealth Scientific and Industrial Research Organisation

发明人： MEULEWAETER, Frank ,  LLEWELLYN, Danny J.

IPC分类号： C12N9/10 ,  C12N15/82 ,  C07K14/415

CPC分类号： C12N15/8223 ,  C07K14/415 ,  C12N9/1051 ,  C12N9/1096 ,  C12N15/8233 ,  C12N15/8237 ,  C12N15/8246 ,  C12Y204/01016 ,  C12Y206/01016

摘要： The present application discloses an isolated nucleic acid sequence comprising (a) at least about 500 consecutive nucleotides of SEQ ID NO: 1; (b) a nucleotide sequence with at least 95% sequence identity to the nucleotide sequence of (a); (c) a nucleotide sequence hybridizing under stringent conditions to the nucleotide sequence of (a) or (b); and (d) a nucleotide sequence complementary to the nucleotide sequence of any one of (a) to (c). Further disclosed herein is a chimeric gene comprising the isolated nucleic acid described herein operably linked to a nucleic acid coding for an expression product of interest, and a transcription termination and polyadenylation sequence. Also disclosed herein are a vector, a transgenic plant cell, a transgenic plant and a seed as characterized in the claims. Methods disclosed herein relate to the production of a transgenic plant, growing cotton, producing a seed, effecting fiber-preferential expression of a product in cotton and of altering fiber properties in a cotton plant as characterized in the claims.

公开(公告)号：EP3201212B1

公开(公告)日：2018-09-19

申请号：EP15847221.7

申请日：2015-10-02

申请人： Conagen Inc.

发明人： MAO, Guohong ,  YU, Xiaodan

IPC分类号： C07H15/256

CPC分类号： C07H15/24 ,  A23L2/60 ,  A23L27/36 ,  A23L33/10 ,  A23V2002/00 ,  C07H1/00 ,  C07H15/256 ,  C07K2319/00 ,  C12N9/1051 ,  C12N9/1062 ,  C12P19/18 ,  C12P19/56 ,  C12Y204/01 ,  C12Y204/01013 ,  C12Y204/01017

摘要： Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).

公开(公告)号：EP3353312A1

公开(公告)日：2018-08-01

申请号：EP16777937.0

申请日：2016-09-21

申请人： Evolva SA

发明人： NAESBY, Michael ,  ZOKOURI, Zina ,  FISCHER, David ,  EICHENBERGER, Michael ,  HANSSON, Anders

IPC分类号： C12P19/44 ,  C12P17/06 ,  C12N15/52

CPC分类号： C12N9/1007 ,  C12N9/0006 ,  C12N9/0071 ,  C12N9/1051 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12P17/06 ,  C12P19/44

摘要： Methods for producing anthocyanin by expression in a microorganism are disclosed including culturing of the microorganism under anthocyanin producing conditions, wherein the microorganism has an operative metabolic pathway including at least one heterologous enzyme activity, the pathway producing anthocyanin from simple sugars or other simple carbon sources.