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1.发明公开SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS 审中-公开取代的咪唑并[1,2-B]哒嗪衍生物，药物组合物和用作β-分泌酶抑制剂的方法
公开(公告)号：EP2549874A1
公开(公告)日：2013-01-30
申请号：EP11759968.8
申请日：2011-03-21
发明人： MJALLI, Adnan, M.M. , HARI, Anitha , GADDAM, Bapu , GOHIMUKKULA, Devi, Reddy , POLISETTI, Dharma, Rao , RAO, Mohan , GOWDA, Raju, Bore , ANDREWS, Robert, Carl , XIE, Rongyuan , SAHOO, Soumya, P. , REN, Tan , BANNER, William, Kenneth
IPC分类号： A01N43/52 , A61K31/415
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutically acceptable salts thereof, and tautomers of any of the foregoing, where such compounds inhibit β-site amyloid precursor protein-cleaving enzyme (BACE), which may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention also provides pharmaceutical compositions comprising any of these compounds and the use of any of these compounds and compositions in the treatment of diseases, disorders, or conditons in which BACE is involved.
摘要翻译： 本发明提供了取代的咪唑并[1,2-b]哒嗪衍生物，其药学上可接受的盐和任何前述的互变异构体，其中这些化合物抑制可能有用的β-位点淀粉样前体蛋白切割酶（BACE） 用于治疗BACE所涉及的疾病，如阿尔茨海默氏病。 本发明还提供了包含任何这些化合物的药物组合物以及这些化合物和组合物中的任何一种在治疗涉及BACE的疾病，病症或病症中的用途。
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2.发明公开SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS -SECRETASE INHIBITORS 审中-公开取代的咪唑并[1,2-a]吡啶衍生物，药物组合物和使用的方法作为B-分泌酶抑制剂
公开(公告)号：EP2424866A1
公开(公告)日：2012-03-07
申请号：EP10714549.2
申请日：2010-04-20
发明人： MJALLI, Adnan, M.M. , HARI, Anitha , GADDAM, Bapu , GOHIMUKKULA, Devi, Reddy , POLISETTI, Dharma, R. , EL ABDELLAOUI, Hassan , RAO, Mohan , ANDREWS, Robert, C. , XIE, Rongyuan , REN, Tan
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61P25/28
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention is directed to substituted imidazo[1,2-a]pyridine derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.
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3.发明公开SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS -SECRETASE INHIBITORS 审中-公开取代的异喹啉衍生物，药物组合物，井井有条用作β-分泌酶抑制剂
公开(公告)号：EP2424533A1
公开(公告)日：2012-03-07
申请号：EP10770133.6
申请日：2010-04-20
发明人： MJALLI, Adnan M. M. , GADDAM, Bapu , GOHIMUKKULA, Devi Reddy , POLISETTI, Dharma Rao , EL ABDELLAOUI, Hassan , RAO, Mohan , WANG, Pingzhen , ANDREWS, Robert Carl , XIE, Rongyuan , REN, Tan
IPC分类号： A61K31/47
CPC分类号： C07D401/12 , C07D401/14
摘要： The present invention is directed to substituted isoquinoline derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.
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