公开(公告)号：EP2594272B1

公开(公告)日：2018-07-11

申请号：EP12007354.9

申请日：2006-05-18

申请人： Horizon Orphan LLC

发明人： Bostian, Keith A. ,  Dudley, Michael N. ,  Surber, Mark ,  Griffith, David C. ,  Lomovskaya, Olga

IPC分类号： A61K31/5383 ,  A61K31/538 ,  A61K31/4375 ,  A61K31/47 ,  A61K9/12 ,  A61P11/00 ,  A61K9/08 ,  A61K33/06 ,  A61K33/14

CPC分类号： A61K9/0078 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/145 ,  A61K31/5383 ,  A61K33/06 ,  A61K33/14 ,  Y02A50/401 ,  Y02A50/469 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/483 ,  A61K2300/00

摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.