公开(公告)号：EP4417256A2

公开(公告)日：2024-08-21

申请号：EP24186385.1

申请日：2014-03-11

Applicant: University of Florida Research Foundation, Inc.

Inventor： VIDYASAGAR, Sadasivan ,  OKUNIEFF, Paul

IPC: A61P11/00

CPC classification number: A61K31/405 ,  A61K31/198 ,  A61K33/14 ,  A61P11/00 ,  A61P11/06 ,  A61P29/00

Abstract: The subject invention provides therapeutic compositions and uses thereof for improving pulmonary function. In one embodiment, the therapeutic composition comprises one or more free amino acids selected from lysine, glycine, threonine, valine, tyrosine, aspartic acid, isoleucine, tryptophan, asparagine, and serine; and electrolytes. In one embodiment, the subject invention can be used to prevent or treat long-term lung complications induced by radiation.

公开(公告)号：EP3954390B1

公开(公告)日：2024-08-07

申请号：EP21180843.1

申请日：2016-11-30

IPC: A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/02 ,  C12N15/87 ,  A61K31/205

CPC classification number: A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61K9/0019 ,  A61K45/06 ,  A61K47/183 ,  A61K33/14 ,  C12N15/87 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/45 ,  C12N9/22

公开(公告)号：EP4368031A1

公开(公告)日：2024-05-15

申请号：EP22837670.3

申请日：2022-07-05

Applicant: AJINOMOTO CO., INC.

Inventor： UEHARA, Akinori ,  SAKAMOTO, Yasuteru

IPC: A23K20/20 ,  A23K20/163 ,  A23K50/75 ,  A61K9/28 ,  A61K31/715 ,  A61K31/717 ,  A61K31/719 ,  A61K31/723 ,  A61K31/731 ,  A61K31/732 ,  A61K31/734 ,  A61K33/14 ,  A61K33/26 ,  A61K47/44 ,  A61P1/04 ,  A61P31/04

CPC classification number: A61K31/731 ,  A61K31/732 ,  A61K47/44 ,  A61K31/723 ,  A61K31/734 ,  A61K31/715 ,  A61K33/14 ,  A61K31/717 ,  A23K20/163 ,  A61P1/04 ,  A61K31/719 ,  A61K33/26 ,  A61K9/28 ,  A23K50/75 ,  A61P31/04 ,  A23K20/20

Abstract: The present invention provides a sporulation inhibitor of Clostridium perfringens containing at least one inorganic compound at a concentration that allows Clostridium perfringens to settle in vivo, wherein the inorganic compound is at least one salt selected from the group consisting of K, Na, Mg, Ca, and Fe, and the inorganic compound is coated with a protective layer containing hydrogenated vegetable oil.

公开(公告)号：EP4351410A1

公开(公告)日：2024-04-17

申请号：EP22821160.3

申请日：2022-06-10

Applicant: Jubilant Draximage, Inc. ,  Yale University

Inventor： SINUSAS, Albert ,  LAFRANCE, Norman

IPC: A61B5/00 ,  A61M5/14 ,  A61K33/14 ,  G06T7/00 ,  G05B19/04 ,  A61P9/10

CPC classification number: A61K33/14 ,  A61P9/10 ,  A61M5/007 ,  A61M5/1723 ,  A61B5/02007 ,  A61B5/02755 ,  A61B5/4842 ,  A61B6/037 ,  A61B2576/0020130101 ,  A61B5/055 ,  A61B5/7275 ,  A61B6/5217 ,  A61B6/504

公开(公告)号：EP2991640B1

公开(公告)日：2018-12-05

申请号：EP14721347.4

申请日：2014-04-30

Applicant: Gambro Lundia AB

Inventor： ÅHL, Petra ,  GODALY, Gabriela ,  STERNBY, Jan ,  WIESLANDER, Anders

IPC: A61K31/194 ,  A61K31/7004 ,  A61K33/10 ,  A61K33/14 ,  A61K33/42 ,  A61P7/08 ,  A61K9/08 ,  A61M1/34

CPC classification number: A61K33/42 ,  A61K9/0019 ,  A61K9/0026 ,  A61K31/194 ,  A61K31/225 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/06 ,  A61K33/10 ,  A61K33/14 ,  A61K47/02 ,  A61M1/1654 ,  A61M1/1672 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3672 ,  A61M1/3675 ,  A61K2300/00

Abstract: The present invention concerns a multipart fluid system for dialysis therapy, wherein the multipart fluid system comprises an anticoagulation fluid and at least one treatment fluid from the group consisting of dialysis fluid and infusion fluids. According to the invention the anticoagulation fluid comprises 15-40 mM citrate; and the at least one treatment fluid comprises 1.5-8 mM citrate and ≧10 mM bicarbonate. The present invention further concerns a system for citrate anticoagulation in an extracorporeal blood circuit.

公开(公告)号：EP3375455A1

公开(公告)日：2018-09-19

申请号：EP17161090.0

申请日：2017-03-15

Applicant: Les Hôpitaux Universitaires de Genève

Inventor： MÉRAT, Rastine

IPC: A61K45/06 ,  A61K31/437 ,  A61K31/472 ,  A61K31/506 ,  A61K31/4439 ,  A61K31/198 ,  A61K31/192 ,  A61K31/513 ,  A61K31/426 ,  A61P35/00 ,  G01N33/50

CPC classification number: A61K45/06 ,  A61P35/00 ,  G01N33/5011 ,  G01N2333/91215 ,  A61K31/437 ,  A61K2300/00 ,  A61K31/506 ,  A61K31/4439 ,  A61K31/426 ,  A61K31/138 ,  A61K31/192 ,  A61K33/14

Abstract: The present invention relates to agents enhancing HuR/ELAV levels for use in the treatment of BRAF-mutated cancers and uses thereof. In particular, the invention relates to the use of agents enhancing HuR/ELAV levels in combination with BRAF inhibitors for the treatment of BRAF-mutated cancers, in particular melanoma and to methods for identifying agents useful for potentiating the effects of BRAF inhibitors, when used in combination.

公开(公告)号：EP2501392B1

公开(公告)日：2018-09-19

申请号：EP10831011.1

申请日：2010-11-19

Applicant: Ortho Regenerative Technologies Inc.

Inventor： OUYANG, Wei ,  BUSCHMANN, Michael ,  CHEVRIER, Anik

IPC: A61K35/14 ,  A61K31/722 ,  C08K11/00 ,  C08K3/00 ,  C08K3/16 ,  C08K5/521 ,  C08L5/08 ,  A61L27/20

CPC classification number: A61K45/06 ,  A61K31/722 ,  A61K33/14 ,  A61K35/16 ,  A61L27/20 ,  A61L27/3616 ,  C08K3/16 ,  C08K5/521 ,  C08L5/08 ,  A61K2300/00

Abstract: The present disclosure relates to an activated polymer composition for use in repairing tissue of a patient comprising platelet-rich plasma (PRP), a chitosan solution, a salt such as NaCI or glycerol phosphate, and an activator such as at least one of CaCI2 and a mixture of thrombin/CaCI2.

公开(公告)号：EP3083504B1

公开(公告)日：2018-07-18

申请号：EP14828154.6

申请日：2014-12-19

Applicant: Oriel Seasalt Company Limited

Inventor： FITZPATRICK, Brian ,  DELANY, John

IPC: A61Q19/00 ,  B01D1/18 ,  A61K8/20 ,  A61K33/14 ,  C02F1/06 ,  C02F1/38 ,  C02F1/467 ,  C01D3/06 ,  C02F1/68 ,  C01F11/46 ,  C02F9/00 ,  C25B1/34 ,  C02F103/02 ,  C02F1/00 ,  C02F1/04 ,  C02F103/08 ,  C02F1/44

CPC classification number: C02F9/00 ,  A61K8/20 ,  A61K33/14 ,  A61K2800/10 ,  A61Q19/00 ,  B01D1/18 ,  C01D3/06 ,  C01F11/46 ,  C02F1/001 ,  C02F1/04 ,  C02F1/06 ,  C02F1/385 ,  C02F1/441 ,  C02F1/444 ,  C02F1/4672 ,  C02F1/68 ,  C02F2103/026 ,  C02F2103/08 ,  C02F2301/063 ,  C25B1/34 ,  Y02A20/128 ,  Y02A20/131

Abstract: A sea water harvesting process includes the steps of collecting sea water, filtering the sea water, passing the filtered sea water through a high-pressure reverse osmosis membrane to separate the sea water into de-salinated water and concentrated sea water, delivering the concentrated sea water to an evaporator, heating the concentrated sea water in the evaporator under vacuum to produce calcium sulphate, sea salt and a super-concentrated sea water. Downstream of the evaporator the super-concentrated sea water is heated to produce a concentrated mineral liquor containing sea minerals in a concentration of about 42%.

公开(公告)号：EP3222304A4

公开(公告)日：2018-07-11

申请号：EP15861342

申请日：2015-11-12

Applicant: NIKKISO CO LTD

Inventor： FUJIWARA MASATO ,  MASUDA YOSHIMICHI ,  NIMURA HIROSHI

IPC: A61M1/14

CPC classification number: A61M1/1666 ,  A61K31/19 ,  A61K33/00 ,  A61K33/14 ,  A61M1/1656 ,  A61M1/1668 ,  A61M1/168 ,  A61M1/3692 ,  A61M2205/3379 ,  A61M2205/3382 ,  A61M2205/3386 ,  A61M2205/3393 ,  A61M2209/10

Abstract: This dialysis-fluid supply system, which mixes a diluent and at least two drugs to generate a dialysis fluid, and outputs said dialysis fluid, is provided with: two tanks which mix the drugs and the diluent to generate the dialysis fluid, and store said dialysis fluid; a water supply device and a drug supply device which supply the diluent and the drugs to each of the tanks; mechanisms for outputting, to a dialysis device, the dialysis fluid stored in each of the tanks; and a control unit for controlling the driving of these. During output of the dialysis fluid from at least one of the tanks, the control unit sequentially switches the supply destination tank for the drugs and the diluent, and the dialysis-fluid output source tank, between the two tanks in order to generate the dialysis fluid in the other tank.

公开(公告)号：EP2931292B1

公开(公告)日：2018-06-13

申请号：EP13821241.0

申请日：2013-12-13

Applicant: Warsaw Orthopedic, Inc. ,  Josee, Roy

Inventor： JOSEE, Roy

IPC: A61K33/06 ,  A61K33/14 ,  A61K31/77 ,  A61K45/00 ,  A61K45/06 ,  A61P25/00 ,  A61K9/00 ,  A61K9/08 ,  A61K47/34

CPC classification number: A61K33/06 ,  A61K9/0019 ,  A61K9/0085 ,  A61K9/08 ,  A61K31/77 ,  A61K33/14 ,  A61K45/06 ,  A61K47/34

Abstract: The disclosure provides compositions, methods and kits for treatment of neuronal injury. In one embodiment, the composition comprises polyethylene glycol (PEG), and magnesium in one composition. In another embodiment, the composition comprises PEG, and magnesium, where the PEG is in separate composition and the magnesium is in a separate composition. In yet another embodiment, the PEG and/or the magnesium may be administered to treat spinal cord injury.