公开(公告)号：EP2658997A1

公开(公告)日：2013-11-06

申请号：EP11807925.0

申请日：2011-12-22

申请人： IFOM Fondazione Istituto Firc di Oncologia Molecolare ,  Instituto Europeo di Oncologia S.r.l. ,  Universita' degli Studi di Milano

发明人： BIANCHI, Fabrizio ,  NICASSIO, Francesco ,  MARZI, Matteo Jacopo Luca Nicolò ,  DI FIORE, Pierpaolo

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/16 ,  C12Q2600/178

摘要： A diagnostic and/or prognostic model of at least 5 serum miRNAs selected among a group of 34 miRNAs that identifies subjects with early stage lung cancer, namely non-small cell lung carcinomas (NSCLCs), in a population of asymptomatic high-risk individuals, with 80% accuracy. The model could also distinguish between benign and malignant lesions and is sensitive enough to capture the disease onset. In addition, the model could also diagnose or confirm a diagnosis of lung cancer in symptomatic patients, and monitor the lung tumor status after treatment with surgery and/or chemotherapy and/or radiotherapy in a subject with such lung cancer.

摘要翻译： 至少5种血清miRNA的一种诊断和/或预后模型的一组34种miRNA识别与早期肺癌，即非小细胞肺癌（非小细胞肺癌）的受试者，在无症状的高风险的个体的群体中选择的， 准确80％。 因此，该模型能够良性和恶性病变区分和足够敏感地捕捉到了疾病发作。 此外，该模型可因此诊断或确认肺癌的症状的患者诊断，和监控与肺癌的受试者检查外科手术和/或化学疗法和/或放射疗法治疗后的肺肿瘤的状态。