公开(公告)号：EP3495502A2

公开(公告)日：2019-06-12

申请号：EP18214115.0

申请日：2014-06-20

申请人： The Chinese University Of Hong Kong

发明人： CHIM, Siu-Chung Stephen ,  CHEUNG, Chee Yin ,  CHEUNG, Wan Chee ,  LEUNG, Tak Yeun ,  LEE, Wing Shan

IPC分类号： C12Q1/68 ,  A61K31/713 ,  A61K48/00

CPC分类号： C12Q1/6883 ,  A61K31/713 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/166 ,  C12Q2600/178

摘要： The present invention provides a method for determining increased risk of premature birth in a pregnant woman by detecting altered expression level of one or more marker genes in the woman's blood. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for preventing or reducing the likelihood of premature birth.

公开(公告)号：EP3212803B1

公开(公告)日：2018-12-26

申请号：EP15741191.9

申请日：2015-07-23

申请人： Hummingbird Diagnostics GmbH

发明人： BREFORT, Thomas ,  FRANKE, Andre ,  HEMMRICH-STANISAK, Georg ,  HÜBENTHAL, Matthias ,  SCHEFFLER, Matthias

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The present invention relates to a method for diagnosis of Inflammatory Bowel Disease (IBD) based on the determination of expression profiles of miRNAs representative for diagnosis of IBD compared to a reference. In addition, the present invention relates to a kit for diagnosis of IBD comprising means for determining expression profiles of miRNAs representative for IBD.

公开(公告)号：EP3134527B1

公开(公告)日：2018-12-12

申请号：EP15717890.6

申请日：2015-04-22

申请人： Medizinische Hochschule Hannover

发明人： THUM, Thomas ,  FIEDLER, Jan

IPC分类号： C12N15/113 ,  A61K31/7088

CPC分类号： C12N15/113 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/20 ,  C12N2320/30 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The present invention relates to a pharmaceutical composition comprising (i) a compound promoting the expression and/or the activity of one or more long non-coding RNAs (lncRNAs) selected from SEQ ID NOs 1 to 22, preferably selected from SEQ ID NOs 1 to 3; and/or (ii) a compound inhibiting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 23 to 42. The present invention also relates to a pharmaceutical composition comprising (i) a compound promoting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 23 to 42; and/or (ii) a compound inhibiting the expression and/or the activity of one or more long non-coding RNAs (lncRNAs) selected from SEQ ID NOs 1 to 22, preferably selected from SEQ ID NOs 1 to 3.

公开(公告)号：EP3408409A1

公开(公告)日：2018-12-05

申请号：EP17702919.6

申请日：2017-01-26

申请人： University College Cardiff Consultants Ltd

发明人： BOWEN, Timothy ,  FRASER, Donald

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The invention relates to a diagnostic method for determining at least one of, or a combination of, the following: has-miR-155-5p, hsa-miR-126-3p and has-miR-29b-3p in a urine sample for determining the existence of, or progression of, chronic kidney disease in a subject; and a kit of parts for undertaking said method.

公开(公告)号：EP3392348A3

公开(公告)日：2018-11-21

申请号：EP18175838.4

申请日：2015-06-15

申请人： Worldwide Innovative Network

发明人： LAZAR, Vladimir

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The present invention relates to a method for determining the best combinations of at least three drugs for treating cancer, which is based on the determination of the most relevant intervention points for an individual.

公开(公告)号：EP3401393A1

公开(公告)日：2018-11-14

申请号：EP18180526.8

申请日：2013-02-21

申请人： Exostem Biotec Ltd ,  Henry Ford Health System

发明人： BRODIE, Chaya

IPC分类号： C12N5/079 ,  A61P25/00 ,  A61P25/16 ,  C12N15/113

CPC分类号： A61K35/30 ,  A61K35/28 ,  A61K35/50 ,  A61K35/51 ,  C12N5/0622 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2330/10 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2501/195 ,  C12N2501/41 ,  C12N2501/65 ,  C12N2502/13 ,  C12N2502/1305 ,  C12N2502/1311 ,  C12N2502/1317 ,  C12N2502/1323 ,  C12N2502/1329 ,  C12N2502/1335 ,  C12N2502/1341 ,  C12N2502/1347 ,  C12N2502/1352 ,  C12N2502/1358 ,  C12N2502/1364 ,  C12N2502/137 ,  C12N2502/1376 ,  C12N2502/1382 ,  C12N2502/1388 ,  C12N2502/1394 ,  C12N2506/025 ,  C12N2506/1353 ,  C12N2506/1369 ,  C12N2506/1384 ,  C12N2506/1392 ,  C12N2510/00 ,  C12Q1/6876 ,  C12Q2600/178

摘要： A method of generating astrocytes is disclosed, the method comprising up-regulating miR-101 and down-regulating miR-138 using an agent which hybridizes to the miRNA in mesenchymal stem cells (MSCs). Isolated cell populations and uses thereof are also disclosed.

公开(公告)号：EP3394290A1

公开(公告)日：2018-10-31

申请号：EP16829076.5

申请日：2016-12-22

申请人： Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

发明人： BELKA, Claus ,  NIYAZI, Karim-Maximilian ,  UNGER, Kristian ,  ZITZELSBERGER, Horst ,  PITEA, Adriana ,  MITTELBRONN, Michel

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The present invention relates to a kit (a) comprising or (b) consisting of means for detecting and/or quantifying one, two, three or all four of the following miRNAs: hsa-miR-615-5p; hsa- miR-125a-5p; hsa-let-7a-5p; and hsa-let-7b-5p.

公开(公告)号：EP3390661A1

公开(公告)日：2018-10-24

申请号：EP16822642.1

申请日：2016-12-16

申请人： Sorbonne Universite ,  Centre National de la Recherche Scientifique ,  Université Pierre et Marie Curie (Paris 6) ,  Institut National de la Santé et de la Recherche Médicale ,  Assistance Publique - Hôpitaux de Paris ,  Universite Paris 12 - Val De Marne

发明人： MORILLON, Antonin ,  LONDONO-VALLEJO, Arturo ,  ALLORY, Yves ,  SACI, Zohra

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/16 ,  C12Q2600/178

摘要： The present invention provides three new antisense long non coding RNAs (lncRNAs) that allow to diagnose prostate cancer much more accurately than the existent non-invasive diagnostic tools. So, this invention relates to the use of at least one of these antisense 1ncRNA or a combination thereof as a diagnosis marker for prostate cancer. It also relates to an in vitro method for prostate cancer diagnosis of a subject as well as to a kit for performing this method.

公开(公告)号：EP3390659A1

公开(公告)日：2018-10-24

申请号：EP16822395.6

申请日：2016-12-14

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Universite Nice Sophia Antipolis

发明人： BENAHMED, Mohamed

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/57434 ,  G01N2800/52

摘要： The present invention relates to methods and kits for diagnosing or prognosing prostate cancer. More particularly, the invention relates to an in vitro method for predicting or diagnosing a prostate cancer in a subject, said method comprising the following steps of: i. measuring the expression levels of miR-101 and miR-195 in a biological sample obtained from said subject; ii. comparing said expression levels of miR-101 and miR-195 with their respective predetermined reference values; and iii. determining whether the subject has or is at risk of having a prostate cancer, wherein an expression level of miR-101 lower than the predetermined reference value and an expression level of miR-195 higher than the predetermined reference value is indicative that the subject has, or is at risk of having a prostate cancer.

公开(公告)号：EP3390635A1

公开(公告)日：2018-10-24

申请号：EP16876615.2

申请日：2016-12-14

申请人： COLD SPRING HARBOR LABORATORY ,  Stoke Therapeutics, Inc.

发明人： AZNAREZ, Isabel ,  NASH, Huw M.

IPC分类号： C12N15/113 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  A61K31/7088 ,  C12N15/1135 ,  C12N2310/11 ,  C12Q2600/156 ,  C12Q2600/178

摘要： Provided herein are methods and compositions for increasing the expression of TSC2, and for treating a subject in need thereof, such as a subject with deficient tuberin protein expression or a subject having tuberous sclerosis complex.