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10 条记录 (耗时 0.018 秒)

    HUMAN CDNAS ENCODING POLYPEPTIDES HAVING KINASE FUNCTIONS
    2.
    发明公开
    HUMAN CDNAS ENCODING POLYPEPTIDES HAVING KINASE FUNCTIONS 审中-公开
    编码与激酶功能代码多肽的cDNA人

    公开(公告)号：EP1032687A2

    公开(公告)日：2000-09-06

    申请号：EP99937783.1

    申请日：1999-08-03

    申请人： IMMUNEX CORPORATION

    发明人： VIRCA, G., Duke ,  BIRD, Timothy, A. ,  ANDERSON, Dirk, M. ,  MARKEN, John, S.

    IPC分类号： C12N15/55 ,  C12N9/12 ,  C07K16/40 ,  G01N33/50

    CPC分类号： C12N9/1205

    摘要： The invention is directed to purified and isolated human polypeptides having kinase function, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in phosphorylation reactions and as molecular weight markers, the use of such polypeptides and fragmented peptides as controls for peptide fragmentation, the use of such polypeptides in screening assays, and kits comprising these reagents.

    RIP-3-LIKE DEATH-ASSOCIATED KINASE
    6.
    发明公开
    RIP-3-LIKE DEATH-ASSOCIATED KINASE 审中-公开
    RIP-3样死亡相关激酶

    公开(公告)号：EP1214414A2

    公开(公告)日：2002-06-19

    申请号：EP00973364.3

    申请日：2000-09-15

    申请人： IMMUNEX CORPORATION

    发明人： VIRCA, G., Duke ,  BIRD, Timothy, A.

    IPC分类号： C12N15/12 ,  C07K14/47 ,  C12N9/12 ,  A61K38/17 ,  C07K16/18 ,  C07K16/40 ,  G01N33/68

    CPC分类号： C12N9/12 ,  A61K38/00 ,  C07K14/4747

    摘要： The invention is directed to purified and isolated novel R3DAK polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, agonists and antagonists of the activities of these polypeptides, and the uses of the above.

    摘要翻译： 本发明涉及纯化和分离的新型R3DAK多肽，编码此类多肽的核酸，生产这些多肽的重组形式的方法，针对这些多肽产生的抗体，这些多肽的活性的激动剂和拮抗剂，以及 以上。

    HEMATOPOIETIN RECEPTORS HPR1 AND HPR2
    8.
    发明公开
    HEMATOPOIETIN RECEPTORS HPR1 AND HPR2 审中-公开
    HPR2下的HPI

    公开(公告)号：EP1326978A2

    公开(公告)日：2003-07-16

    申请号：EP01986320.8

    申请日：2001-10-05

    申请人： Immunex CorporatioN

    发明人： COSMAN, David, J. ,  MOSLEY, Bruce, A. ,  BIRD, Timothy, A. ,  DUBOSE, Robert, F. ,  WILEY, Steven, R.

    IPC分类号： C12N15/12 ,  C07K14/705

    CPC分类号： G01N33/6863 ,  C07K14/715 ,  C07K2319/00 ,  G01N33/74

    摘要： This invention relates to human and murine HPR1 and human and murine HPR2 polypeptides, new members of the hematopoietin receptor polypeptide family; to methods of making such HPR1 and HPR2 polypeptides; to non-human mammals in which the endogenous genomic sequences encoding HPR1 and/or HPR2 polypeptides have been partially or completely inactivated; to methods of using HPR1 or HPR2 polypeptides to identify compounds that alter HPR1 or HPR2 polypeptide activities; and to methods of preparing medicaments for and/or treating conditions associated with hematopoietin receptor function.

    摘要翻译： 本发明涉及人和鼠HPR1和人和鼠HPR2多肽，造血细胞因子受体多肽家族的新成员; 涉及制备此类HPR1和HPR2多肽的方法; 涉及编码HPR1和/或HPR2多肽的内源基因组序列部分或完全失活的非人哺乳动物; 涉及使用HPR1或HPR2多肽鉴定改变HPR1或HPR2多肽活性的化合物的方法; 以及制备用于和/或治疗与造血细胞因子受体功能相关的药物的方法。