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1.发明授权
公开(公告)号：EP0201540B2
公开(公告)日：2001-10-31
申请号：EP85905513.9
申请日：1985-10-18
发明人： MONTAGNIER, Luc , KRUST, Bernard , CHAMARET, Solange , CLAVEL, François , CHERMANN, Jean-Claude , BARRE-SINOUSSI, Françoise , ALIZON, Marc , SONIGO, Pierre , STEWART, Cole , DANOS, Olivier , WAIN-HOBSON, Simon
IPC分类号： C07K14/16
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/1054 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/702 , C12Q1/703 , G01N33/531
摘要： Purified expression products of DNA sequences derived of the genome of the LAV virus. It relates more particularly to a glycoprotein having a molecular weight of about 110,000 or antigen of lower molecular weight derived from the preceding one, which purified product possesses the capacity of being recognised by serums of human origin and containing antibodies against the LAV virus. It also relates to other purified polypeptides derived either from the abovesaid glycoprotein or of core proteins of LAV virus. The glycoprotein can be used for the production of immunogenic composition capable of neutralizing the LAV virus. All of the abovesaid glycoprotein or polypeptides can be used as antigens useful in the diagnosis of LAV antibodies in sera of patients.
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2.发明授权
公开(公告)号：EP0201540B1
公开(公告)日：1991-06-19
申请号：EP85905513.9
申请日：1985-10-18
发明人： MONTAGNIER, Luc , KRUST, Bernard , CHAMARET, Solange , CLAVEL, François , CHERMANN, Jean-Claude , BARRE-SINOUSSI, Françoise , ALIZON, Marc , SONIGO, Pierre , STEWART, Cole , DANOS, Olivier , WAIN-HOBSON, Simon
IPC分类号： C07K13/00 , C07K3/00 , C12N15/49 , G01N33/569 , A61K39/21
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/1054 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/702 , C12Q1/703 , G01N33/531
摘要： Purified expression products of DNA sequences derived of the genome of the LAV virus. It relates more particularly to a glycoprotein having a molecular weight of about 110,000 or antigen of lower molecular weight derived from the preceding one, which purified product possesses the capacity of being recognised by serums of human origin and containing antibodies against the LAV virus. It also relates to other purified polypeptides derived either from the abovesaid glycoprotein or of core proteins of LAV virus. The glycoprotein can be used for the production of immunogenic composition capable of neutralizing the LAV virus. All of the abovesaid glycoprotein or polypeptides can be used as antigens useful in the diagnosis of LAV antibodies in sera of patients.
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3.发明公开
公开(公告)号：EP0201540A1
公开(公告)日：1986-11-20
申请号：EP85905513.0
申请日：1985-10-18
发明人： MONTAGNIER, Luc , KRUST, Bernard , CHAMARET, Solange , CLAVEL, François , CHERMANN, Jean-Claude , BARRE-SINOUSSI, Françoise , ALIZON, Marc , SONIGO, Pierre , STEWART, Cole , DANOS, Olivier , WAIN-HOBSON, Simon
IPC分类号： G01N33 , A61K39 , A61P31 , C07H21 , C07K1 , C07K7 , C07K14 , C07K16 , C12N15 , C12P21 , C12Q1 , A61K38 , C12R1
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/1054 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/702 , C12Q1/703 , G01N33/531
摘要： Produits purifiés d'expression de séquences d'ADN dérivées du génome du virus LAV. On décrit particulièrement une glycoprotéine possédant un poids moléculaire d'environ 110 000 ou un antigène de poids moléculaire inférieur dérivé de ladite glycoprotéine, ce produit purifié pouvant être reconnu par des sérums d'origine humaine et contenant des anticorps contre le virus LAV. L'invention se rapporte également à d'autres polypeptides purifiés dérivés soit de ladite glycoprotéine soit de protéines de noyau du virus LAV. La glycoprotéine peut être utilisée pour la production de compositions immunogènes pouvant neutraliser le virus LAV. La glycoprotéine ou les polypeptides ci-décrits peuvent être utilisés comme antigènes utiles dans le diagnostic d'anticorps du LAV dans les sérum prélevés chez les patients.
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