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    KITS FOR GENOTYPING
    1.
    发明公开
    KITS FOR GENOTYPING 审中-公开

    公开(公告)号：EP4253559A2

    公开(公告)日：2023-10-04

    申请号：EP23180094.7

    申请日：2021-02-24

    申请人： Illumina, Inc. ,  Illumina Cambridge Limited

    发明人： SLATTER, Andrew ,  VERMAAS, Eric Hans

    IPC分类号： C12Q1/6806

    摘要： An example of a kit includes a flow cell and a genotyping probe fluid. The flow cell includes a substrate, and first and second capture primers attached to the substrate. The genotyping probe fluid includes a liquid carrier, and a genotyping oligonucleotide in the liquid carrier. The genotyping oligonucleotide includes a first primer sequence; a probe sequence that is representative of a target genotyping locus; a restriction endonuclease site; and a second primer sequence that is at least partially complementary to the second capture primer.

    KITS FOR GENOTYPING
    6.
    发明公开
    KITS FOR GENOTYPING 审中-公开

    公开(公告)号：EP4253559A3

    公开(公告)日：2023-10-25

    申请号：EP23180094.7

    申请日：2021-02-24

    申请人： Illumina, Inc. ,  Illumina Cambridge Limited

    发明人： SLATTER, Andrew ,  VERMAAS, Eric Hans

    IPC分类号： C12Q1/6806

    摘要： An example of a kit includes a flow cell and a genotyping probe fluid. The flow cell includes a substrate, and first and second capture primers attached to the substrate. The genotyping probe fluid includes a liquid carrier, and a genotyping oligonucleotide in the liquid carrier. The genotyping oligonucleotide includes a first primer sequence; a probe sequence that is representative of a target genotyping locus; a restriction endonuclease site; and a second primer sequence that is at least partially complementary to the second capture primer.

    TIME-BASED CLUSTER IMAGING OF AMPLIFIED CONTIGUITY PRESERVED LIBRARY FRAGMENTS OF GENOMIC DNA
    9.
    发明公开
    TIME-BASED CLUSTER IMAGING OF AMPLIFIED CONTIGUITY PRESERVED LIBRARY FRAGMENTS OF GENOMIC DNA 审中-公开

    公开(公告)号：EP4219755A3

    公开(公告)日：2023-08-23

    申请号：EP23161744.0

    申请日：2020-12-01

    申请人： Illumina Cambridge Limited

    发明人： MORRELL, Natalie ,  SLATTER, Andrew ,  THOMSON, Vicki

    IPC分类号： C12Q1/6844

    摘要： In an example method, a series of time-based clustering images is generated for a plurality of library fragments from a genome sample. Each time-based clustering image in the series is sequentially generated. To generate each time-based clustering image in the series: i) a respective sample is introduced to a flow cell, the respective sample including contiguity preserved library fragments of the plurality of library fragments, wherein the contiguity preserved library fragments are attached to a solid support or are attached to each other; ii) the contiguity preserved library fragments are released from the solid support or from each other; iii) the contiguity preserved library fragments are amplified to generate a plurality of respective template strands; iv) the respective template strands are stained; and v) the respective template strands are imaged.