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公开(公告)号：EP4314283A1
公开(公告)日：2024-02-07
申请号：EP22723498.6
申请日：2022-03-29
发明人： VERITY, Susan C. , KUERSTEN, Robert Scott , GORMLEY, Niall Anthony , KENNEDY, Andrew B. , SHULTZABERGER, Sarah E. , SLATTER, Andrew , BELL, Emma , RICOULT, Sebastien Georg Gabriel , DESANTIS, Grace , KAPER, Fiona , CHUANG, Han-Yu , MILLER, Oliver Jon , BETLEY, Jason Richard , GROSS, Stephen , EKSTRAND, Mats
IPC分类号： C12N15/10 , C12Q1/6806
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公开(公告)号：EP2670864B1
公开(公告)日：2017-03-08
申请号：EP12741790.5
申请日：2012-01-12
发明人： KLAUSING, Kay , SHEN, Min-Jui Richard , MOORE, John , SMITH, Vincent , HALL, Kevin , GORMLEY, Niall Anthony , IOANNOU, Avgousta , FRITZILAS, Epameinondas , RIGATTI, Roberto
CPC分类号： C12P19/34 , C12N15/1003 , C12Q1/6806 , C12Q2521/531 , C12Q2527/125 , C12Q2563/131
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公开(公告)号：EP2670864A2
公开(公告)日：2013-12-11
申请号：EP12741790.5
申请日：2012-01-12
发明人： KLAUSING, Kay , SHEN, Min-Jui Richard , MOORE, John , SMITH, Vincent , HALL, Kevin , GORMLEY, Niall Anthony , IOANNOU, Avgousta , FRITZILAS, Epameinondas , RIGATTI, Roberto
CPC分类号： C12P19/34 , C12N15/1003 , C12Q1/6806 , C12Q2521/531 , C12Q2527/125 , C12Q2563/131
摘要： Provided herein is a method of inhibiting degradation of nucleic acids during a nucleic acid processing step selected from fragmentation and detection comprising contacting the nucleic acids with a solution comprising gallic acid, analogues, derivatives thereof or mixtures thereof, during the processing step, wherein the contacting inhibits degradation of the nucleic acids. Also provided herein is a method of inhibiting light-induced degradation of nucleic acids. Additionally, provided herein is a method of reducing or inhibiting nucleic acid damage during preparation of a nucleic acid sample comprising fragmenting the nucleic acid sequences in the sample in a solution comprising one of more compounds, the compounds inhibiting degradation of the nucleic acid sequences in the sample.
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4.发明公开
公开(公告)号：EP4232600A2
公开(公告)日：2023-08-30
申请号：EP21807406.0
申请日：2021-10-20
IPC分类号： C12Q1/6834 , C12Q1/6874
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公开(公告)号：EP4200416A1
公开(公告)日：2023-06-28
申请号：EP21778594.8
申请日：2021-08-17
发明人： STEEMERS, Frank J. , BOUTELL, Jonathan Mark , GATTI LAFRANCONI, Pietro , MILLER, Oliver Jon , BELL, Emma , RICOULT, Sebastien Georg Gabriel , GORMLEY, Niall Anthony , SCHNEIDER, Kim
IPC分类号： C12N15/10 , C12Q1/6806
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公开(公告)号：EP1987159B2
公开(公告)日：2020-08-12
申请号：EP07705178.7
申请日：2007-02-08
发明人： VERMAAS, Eric Hans , WORSLEY, Graham John , BOUTELL, Jonathan Mark , BARNES, Colin Lloyd , RIGATTI, Roberto , GORMLEY, Niall Anthony , SMITH, Geoffrey Paul , SMITH, Vincent Peter , OST, Tobias William Barr , BENTLEY, David
IPC分类号： C12Q1/6869
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公开(公告)号：EP3207134A2
公开(公告)日：2017-08-23
申请号：EP15797490.8
申请日：2015-10-16
发明人： STEEMERS, Frank J. , GUNDERSON, Kevin L. , ZHANG, Fan , BETLEY, Jason Richard , GORMLEY, Niall Anthony , MEULEMAN, Wouter , WEIR, Jacqueline , IOANNOU, Avgousta , JENKINS, Gareth , JACKSON, Rosamond , MORRELL, Natalie , POKHOLOK, Dmitry K. , NORBERG, Steven J. , HE, Molly , KIA, Amirali , GORYSHIN, Igor , PANTOJA, Rigo
IPC分类号： C12N15/10
CPC分类号： C12N15/1093 , C12N15/1065 , C12Q2525/191 , C12Q2563/179 , C12Q2565/514
摘要： Embodiments provided herein relate to methods and compositions for preparing an immobilized library of barcoded DNA fragments of a target nucleic acid, identifying genomic variants, determining the contiguity information, phasing information, and methylation status of the target nucleic acid.
摘要翻译： 本文提供的实施方案涉及用于制备靶核酸的条形码化DNA片段的固定文库，鉴定基因组变体，确定靶核酸的邻接信息，定相信息和甲基化状态的方法和组合物。
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公开(公告)号：EP3205730A1
公开(公告)日：2017-08-16
申请号：EP17161616.2
申请日：2011-08-29
IPC分类号： C12Q1/68
摘要： Provided herein is a method for sequencing a polynucleotide molecules. The method includes the steps of providing a plurality of polynucleotide molecules attached to a surface, wherein a first portion of each polynucleotide molecule is attached to a first location of the surface and a second portion of each polynucleotide molecule is attached to a second location of the surface, the relative proximity of the first and second locations being correlated with the probability that the first and second portions are paired, separating the first and second portions of the polynucleotide molecules on the surface, determining the sequences of the first and second portions of the polynucleotide molecules and comparing the relative proximities and the sequences to determine which first and second portions are paired and to determine the sequence of the target polynucleotide molecules.
摘要翻译： 本文提供了用于测序多核苷酸分子的方法。 该方法包括以下步骤：提供附着于表面的多个多核苷酸分子，其中每个多核苷酸分子的第一部分连接至表面的第一位置，并且每个多核苷酸分子的第二部分连接至表面的第二位置 表面，第一和第二位置的相对接近度与第一和第二部分配对的概率相关，分离表面上的多核苷酸分子的第一和第二部分，确定第一和第二部分的第一和第二部分的序列 多核苷酸分子，并比较相对邻近性和序列以确定哪一个第一和第二部分配对并确定靶多核苷酸分子的序列。
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公开(公告)号：EP1957668B1
公开(公告)日：2015-04-08
申请号：EP06808675.0
申请日：2006-11-24
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6855 , C12Q2565/537
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公开(公告)号：EP2823058A1
公开(公告)日：2015-01-14
申请号：EP13714865.6
申请日：2013-03-06
IPC分类号： C12Q1/68
CPC分类号： G01N33/58 , C12Q1/6806 , C12Q1/6834 , C12Q1/6855 , C12Q1/6869 , C12Q2521/301 , C12Q2521/319 , C12Q2521/327 , C12Q2525/155 , C12Q2525/191 , C12Q2535/122 , C12Q2565/518
摘要： Provided herein is a method of using transposition to improve methods of sequencing RNA molecules. Provided herein is a method of tagging nucleic acid duplexes, such as DNA:RNA duplexes or DNA:DNA duplexes. The method includes the steps of providing a transposase and a transposon composition, providing one or more nucleic acid duplexes immobilized on a support, and contacting the transposase and transposon composition with the one or more nucleic acid duplexes under conditions wherein the one or more nucleic acid duplexes and transposon composition undergo a transposition reaction to produce one or more tagged nucleic acid duplexes, wherein the transposon composition comprises a double stranded nucleic acid molecule comprising a transferred strand and a non-transferred strand.
摘要翻译： 本文提供了使用转座来改进RNA分子测序方法的方法。 本文提供了标记核酸双链体的方法，例如DNA：RNA双链体或DNA：DNA双链体。 该方法包括以下步骤：提供转座酶和转座子组合物，提供固定在支持物上的一种或多种核酸双链体，以及在一种或多种核酸在一种或多种核酸条件下与一种或多种核酸双链体接触转座酶和转座子组合物 双链体和转座子组合物经历转位反应以产生一个或多个标记的核酸双链体，其中所述转座子组合物包含含有转移链和非转移链的双链核酸分子。
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