公开(公告)号：EP2515977B1

公开(公告)日：2018-03-07

申请号：EP10813136.8

申请日：2010-12-26

申请人： INSPIRO MEDICAL LTD.

发明人： KAUFMANN, Nimrod ,  STEUER, Guy

IPC分类号： A61M15/00

CPC分类号： A61M15/0028 ,  A61M11/001 ,  A61M11/005 ,  A61M11/02 ,  A61M11/06 ,  A61M15/0003 ,  A61M15/001 ,  A61M15/0016 ,  A61M15/0018 ,  A61M15/0021 ,  A61M15/003 ,  A61M15/0035 ,  A61M15/0038 ,  A61M15/0045 ,  A61M15/008 ,  A61M15/0081 ,  A61M15/0085 ,  A61M16/0063 ,  A61M16/06 ,  A61M16/0666 ,  A61M16/14 ,  A61M16/202 ,  A61M16/204 ,  A61M2016/0021 ,  A61M2016/0033 ,  A61M2202/0208 ,  A61M2202/025 ,  A61M2202/064 ,  A61M2205/07 ,  A61M2205/071 ,  A61M2205/27 ,  A61M2205/276 ,  A61M2205/3331 ,  A61M2205/3355 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2205/6018 ,  A61M2205/6054 ,  A61M2205/6072 ,  A61M2205/8206 ,  A61M2205/8237 ,  A61M2206/16 ,  A61M2209/06 ,  A61M2230/201 ,  A61M2230/30

摘要： A method of flowing a medicament containing powder using gas, including, providing a volume of a gas according to one or more release conditions; directing flow of said gas through or adjacent a powder including a medicament; and releasing a therapeutically effective amount of said powder using said gas. Optionally, the releasing comprises releasing according to breath considerations. Optionally or alternatively, the releasing comprises releasing according to time considerations. In an exemplary embodiment of the invention, the powder is held in a capsule that has apertures formed therein.

公开(公告)号：EP3116569B1

公开(公告)日：2018-02-28

申请号：EP15715459.2

申请日：2015-03-10

申请人： Inspiro Medical Ltd.

发明人： KAUFMANN, Nimrod

IPC分类号： A61M15/00

CPC分类号： A61M15/0041 ,  A61M11/02 ,  A61M15/0003 ,  A61M15/002 ,  A61M15/0028 ,  A61M15/0036 ,  A61M2016/0021 ,  A61M2202/064 ,  A61M2205/3334 ,  A61M2205/502 ,  A61M2206/16 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/005

摘要： A method of flowing a medicament comprising dry powder using gas, including preparing a medicament capsule with designated inflow and outflow apertures, introducing a volume of a gas to within a medicament capsule according to one or more release conditions, and releasing a therapeutically effective amount of said powder using said gas. In some embodiments, the medicament capsule apertures are prepared and/or gas delivered to it so that deagglomeration potentially occurs largely within the energetic flow conditions of the capsule, without significant trapping of residual powder by structures such as aperture edge irregularities.

公开(公告)号：EP3116569A1

公开(公告)日：2017-01-18

申请号：EP15715459.2

申请日：2015-03-10

申请人： Inspiro Medical Ltd.

发明人： KAUFMANN, Nimrod

IPC分类号： A61M15/00

CPC分类号： A61M15/0041 ,  A61M11/02 ,  A61M15/0003 ,  A61M15/002 ,  A61M15/0028 ,  A61M15/0036 ,  A61M2016/0021 ,  A61M2202/064 ,  A61M2205/3334 ,  A61M2205/502 ,  A61M2206/16 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/005

摘要： A method of flowing a medicament comprising dry powder using gas, including preparing a medicament capsule with designated inflow and outflow apertures, introducing a volume of a gas to within a medicament capsule according to one or more release conditions, and releasing a therapeutically effective amount of said powder using said gas. In some embodiments, the medicament capsule apertures are prepared and/or gas delivered to it so that deagglomeration potentially occurs largely within the energetic flow conditions of the capsule, without significant trapping of residual powder by structures such as aperture edge irregularities.

摘要翻译： 一种使用气体流动包含干粉的药物的方法，包括制备具有指定的流入和流出孔的药物胶囊，根据一种或多种释放条件将一定体积的气体引入药物胶囊内，并释放治疗有效量的 所说的粉末使用所说的气体。 在一些实施方案中，制备药物胶囊孔口和/或将气体输送到其中，使得解聚集潜在地在胶囊的能量流动条件下潜在地发生，而不会通过诸如孔边缘不规则性的结构显着捕获残留的粉末。

公开(公告)号：EP2515977A2

公开(公告)日：2012-10-31

申请号：EP10813136.8

申请日：2010-12-26

申请人： INSPIRO MEDICAL LTD.

发明人： KAUFMANN, Nimrod ,  STEUER, Guy

IPC分类号： A61M15/00

CPC分类号： A61M15/0028 ,  A61M11/001 ,  A61M11/005 ,  A61M11/02 ,  A61M11/06 ,  A61M15/0003 ,  A61M15/001 ,  A61M15/0016 ,  A61M15/0018 ,  A61M15/0021 ,  A61M15/003 ,  A61M15/0035 ,  A61M15/0038 ,  A61M15/0045 ,  A61M15/008 ,  A61M15/0081 ,  A61M15/0085 ,  A61M16/0063 ,  A61M16/06 ,  A61M16/0666 ,  A61M16/14 ,  A61M16/202 ,  A61M16/204 ,  A61M2016/0021 ,  A61M2016/0033 ,  A61M2202/0208 ,  A61M2202/025 ,  A61M2202/064 ,  A61M2205/07 ,  A61M2205/071 ,  A61M2205/27 ,  A61M2205/276 ,  A61M2205/3331 ,  A61M2205/3355 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2205/6018 ,  A61M2205/6054 ,  A61M2205/6072 ,  A61M2205/8206 ,  A61M2205/8237 ,  A61M2206/16 ,  A61M2209/06 ,  A61M2230/201 ,  A61M2230/30

摘要： A method of flowing a medicament containing powder using gas, including, providing a volume of a gas according to one or more release conditions; directing flow of said gas through or adjacent a powder including a medicament; and releasing a therapeutically effective amount of said powder using said gas. Optionally, the releasing comprises releasing according to breath considerations. Optionally or alternatively, the releasing comprises releasing according to time considerations. In an exemplary embodiment of the invention, the powder is held in a capsule that has apertures formed therein.

摘要翻译： 一种使用气体使含有药物的粉末流动的方法，包括根据一个或多个释放条件提供一定体积的气体; 引导所述气体通过或邻近包含药物的粉末的流动; 并使用所述气体释放治疗有效量的所述粉末。 可选地，释放包括根据呼吸考虑释放。 可选地或可选地，释放包括根据时间考虑释放。 在本发明的示例性实施例中，粉末被保持在其中形成有孔的胶囊中。