公开(公告)号：EP1235065A1

公开(公告)日：2002-08-28

申请号：EP00979061.9

申请日：2000-12-04

申请人： Japan Science and Technology Corporation

发明人： INOUE, Yoshihisa ,  BOROVKOV, Victor ,  LINTULUOTO, Juha, The 29-703

IPC分类号： G01N21/19 ,  G01N21/77 ,  C07D487/22 ,  C09B47/00

CPC分类号： C07D487/22 ,  C09B47/00 ,  Y10T436/145555 ,  Y10T436/173845 ,  Y10T436/174614

摘要： The object of the present invention is to provide a novel general-purpose method of precisely and easily determining the absolute configuration of chiral compounds having a wide variety of basic groups.
The present invention provides a method for determining the absolute configuration of a chiral compound which comprises:

coordinating the chiral compound to a metalloporphyrin, the metalloporphyrin having a carbon chain-crosslinked porphyrin dimer structure in which one of the two porphyrin rings has at least one ethyl or substituent bulkier than ethyl at at least one of the second peripheral carbon atoms from the carbon atom at the carbon chain crosslink site,
the chiral compound having an asymmetric carbon bonded to a basic group capable of coordinating to the metal of the other porphyrin ring of the metalloporphyrin dimer or an asymmetric carbon atom adjacent to the carbon atom bonded to the basic group; and
analyzing the resultant coordination compound by circular dichroism spectrophotometry to determine the absolute configuration of the asymmetric carbon of the chiral compound based on the sign of the Cotton effect.

摘要翻译： 本发明的目的是提供一种新颖的通用方法，其精确且容易地确定具有多种基团的手性化合物的绝对构型。 本发明提供了一种用于确定手性化合物的绝对构型的方法，其包括：将手性化合物与金属卟啉配位，金属卟啉具有碳链交联的卟啉二聚体结构，其中两个卟啉环中的一个具有至少一个乙基 或在碳链交联部位的碳原子的至少一个第二外周碳原子上比乙基更大的取代基，所述手性化合物具有与能够与其他卟啉环的金属配位的碱性基团键合的不对称碳 金属卟啉二聚体或与结合到碱性基团上的碳原子相邻的不对称碳原子; 并通过圆二色性分光光度法分析得到的配位化合物，以确定手性化合物的不对称碳的绝对构型，基于棉花效应的符号。

公开(公告)号：EP1235065B1

公开(公告)日：2004-08-04

申请号：EP00979061.9

申请日：2000-12-04

申请人： JAPAN SCIENCE AND TECHNOLOGY CORPORATION

发明人： INOUE, Yoshihisa ,  BOROVKOV, Victor ,  LINTULUOTO, Juha, The 29-703

IPC分类号： G01N21/19 ,  G01N21/77 ,  C07D487/22 ,  C09B47/00 ,  C07D519/00

CPC分类号： C07D487/22 ,  C09B47/00 ,  Y10T436/145555 ,  Y10T436/173845 ,  Y10T436/174614

摘要： A novel general-purpose method of precisely and easily determining the absolute configuration of a chiral compound which can have various kinds of basic groups bonded. The method uses a metal porphyrin having a structure which comprises a porphyrin dimer crosslinked with a carbon chain and in which one of the two porphyrin rings has a substituent bulkier than an ethyl group and bonded to at least one of the second peripheral carbon atoms from the carbon atom at the crosslink with the carbon chain. In this method, either a chiral compound having an asymmetric carbon atom having, bonded thereto, a basic group capable of coordinating to the metal of the other porphyrin ring of the dimer structure of the metal porphyrin or a chiral compound having an asymmetric carbon atom adjacent to a carbon atom having the basic group bonded thereto is coordinated to the metal porphyrin. The resultant coordination compound is analyzed by spectrophotometry based on circular dichroism to determine the absolute configuration of the chiral compound based on the symbol of a Cotton effect.