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    1,4-Dihydropyridine derivatives
    2.
    发明公开
    1,4-Dihydropyridine derivatives 失效
    -1,4-二氢吡啶衍生物在。

    公开(公告)号：EP0093945A2

    公开(公告)日：1983-11-16

    申请号：EP83104076.1

    申请日：1983-04-26

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Watanabe, Minoru ,  Moto, Kenji ,  Takemoto, Yoshinori ,  Hatta, Takao ,  Hashimoto, Tamotsu ,  Yamada, Koji

    IPC分类号： C07D211/94 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12 ,  A61K31/445

    CPC分类号： C07D405/12 ,  C07C205/56 ,  C07D211/90 ,  C07D211/94 ,  C07D409/12 ,  Y10S514/929

    摘要： Compounds having effects to dilate coronary artery and peripheral blood vessels and to depress the blood pressure, and useful as drugs for cardiovascular disease are represented by the following general formula:
    wherein R, represents a hydrogen atom, an alkyl group having 1-5 carbon atoms, an alkenyl group having 2-5 carbon atoms, an aralkyl group having 7-13 carbon atoms or an acyl group having 1-7 carbon atoms, R. and R 3 are the same or different groups and each represents a substituted or unsubstituted alkyl group having 1-5 carbon atoms, an alkenyl group having 2-5 carbon atoms, a disubstituted aminoalkyl group having 1-5 carbon atoms or a substituted or unsubstituted heterocyclic group, R 4 and R 5 are the same or different groups and each represents a hydrogen atom, a halogen atom or a nitro group, and R 6 and R 7 are the same or different groups and each represents an alkyl group having 1-5 carbon atoms; the pharmaceutically acceptable acid addition salt thereof are also effective therapeutic compounds.

    摘要翻译： 具有扩张冠状动脉和外周血管并降低血压的效果的化合物可用作心血管疾病的药物，由以下通式表示：... 其中R1表示氢原子，具有1个 -5个碳原子，具有2-5个碳原子的烯基，具有7-13个碳原子的芳烷基或具有1-7个碳原子的酰基，R2和R3是相同或不同的基团，并且各自表示取代或 具有1-5个碳原子的未取代的烷基，具有2-5个碳原子的烯基，具有1-5个碳原子的二取代的氨基烷基或者取代或未取代的杂环基，R4和R5分别相同或不同， 氢原子，卤原子或硝基，R 6和R 7相同或不同，各自表示碳原子数为1〜5的烷基。 其药学上可接受的酸加成盐也是有效的治疗化合物。

    1,4-Dihydropyridine derivatives
    4.
    发明公开
    1,4-Dihydropyridine derivatives 失效
    1,4-二氢吡啶衍生物

    公开(公告)号：EP0093945A3

    公开(公告)日：1984-09-12

    申请号：EP83104076

    申请日：1983-04-26

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Watanabe, Minoru ,  Moto, Kenji ,  Takemoto, Yoshinori ,  Hatta, Takao ,  Hashimoto, Tamotsu ,  Yamada, Koji

    IPC分类号： C07D211/94 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12 ,  A61K31/445

    CPC分类号： C07D405/12 ,  C07C205/56 ,  C07D211/90 ,  C07D211/94 ,  C07D409/12 ,  Y10S514/929

    摘要： Compounds having effects to dilate coronary artery and peripheral blood vessels and to depress the blood pressure, and useful as drugs for cardiovascular disease are represented by the following general formula:
    wherein R, represents a hydrogen atom, an alkyl group having 1-5 carbon atoms, an alkenyl group having 2-5 carbon atoms, an aralkyl group having 7-13 carbon atoms or an acyl group having 1-7 carbon atoms, R. and R 3 are the same or different groups and each represents a substituted or unsubstituted alkyl group having 1-5 carbon atoms, an alkenyl group having 2-5 carbon atoms, a disubstituted aminoalkyl group having 1-5 carbon atoms or a substituted or unsubstituted heterocyclic group, R 4 and R 5 are the same or different groups and each represents a hydrogen atom, a halogen atom or a nitro group, and R 6 and R 7 are the same or different groups and each represents an alkyl group having 1-5 carbon atoms; the pharmaceutically acceptable acid addition salt thereof are also effective therapeutic compounds.

    摘要翻译： 具有扩张冠状动脉和外周血管并降低血压的作用的化合物可用作心血管疾病的药物，其由下列通式表示：其中R 1代表氢原子，具有1-5个碳原子的烷基 具有2-5个碳原子的烯基，具有7-13个碳原子的芳烷基或具有1-7个碳原子的酰基，R和R3是相同或不同的基团并且各自表示取代或未取代的烷基 具有1-5个碳原子的链烯基，具有2-5个碳原子的链烯基，具有1-5个碳原子的二取代氨基烷基或取代或未取代的杂环基，R 4和R 5是相同或不同的基团并且各自表示氢原子 卤素原子或硝基，R6和R7是相同或不同的基团，每个代表具有1-5个碳原子的烷基; 其药学上可接受的酸加成盐也是有效的治疗化合物。