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公开(公告)号：EP0273388A3
公开(公告)日：1989-04-26
申请号：EP87119132.6
申请日：1987-12-23
申请人： MECT CORPORATION
发明人： Yoshimura, Shoji , Shibayama, Shohei , Numata, Masaaki , Ito, Masayoshi , Shitori, Yoshiyasu , Ogawa, Tomoya
摘要： A sialic acid derivative having an active carbonyl group represented by the formula [I]:
(wherein R' represents hydrogen or acetyl group; R 2 represents hydrogen, a metal or a lower alkyl group; R 3 represents hydrogen, hydroxyl group, or a residue removed hydrogen from an alcohol portion of an active ester; Ac represents acetyl group; and n is 1 to 20, respectively). This sialic acid derivative [I] can be utilized as a starting material for various complex having a sialic acid in the molecule since it has an active carbonyl group in the molecule so that it shows high reactivity.-
公开(公告)号：EP0194563A2
公开(公告)日：1986-09-17
申请号：EP86102857.9
申请日：1986-03-05
申请人： MECT Corporation
发明人： Shibayama, Shohei , Matsuzaki, Yuzi , Yoshimura, Shoji , Ito, Masayoshi , Shitori, Yoshiyasu , Ogawa, Tomoya
CPC分类号： C07H15/26
摘要： This invention provides a novel compound having a formula such as
This invention also provides a process for preparing such a compound. The novel compound has excellent immunological activity.-
3.发明公开N-substituted neuraminic acid derivatives and process for preparation thereof 失效N-取代的神经氨酸的衍生物和它们的制备方法。
公开(公告)号：EP0160925A2
公开(公告)日：1985-11-13
申请号：EP85105295.1
申请日：1985-04-30
申请人： MECT Corporation
CPC分类号： C07H15/04
摘要： This invention provides a novel compound having a formula such as
or
This invention also provides a process for preparing such a compound. The novel compound has an excellent immunological activity.-
4.发明授权Glycolipid containing N-glycolylneuraminic acid and method of procuding the same 失效的N-Glykoneuraminsäure包含用于其生产糖脂和方法。
公开(公告)号：EP0264889B1
公开(公告)日：1994-02-09
申请号：EP87115283.1
申请日：1987-10-19
申请人： MECT CORPORATION
发明人： Ogawa, Tomoya , Numata, Masaaki , Sugimoto, Mamoru , Shibayama, Shohei , Yoshimura, Shoji , Ito, Masayoshi , Shitori, Yoshiyasu
IPC分类号： C07H15/10
CPC分类号： C07H15/10
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5.发明授权N-substituted neuraminic acid derivatives and process for preparation thereof 失效N-取代的神经酰胺酸衍生物及其制备方法
公开(公告)号：EP0160925B1
公开(公告)日：1990-07-18
申请号：EP85105295.1
申请日：1985-04-30
申请人： MECT Corporation
CPC分类号： C07H15/04
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6.发明公开Glycolipid containing N-glycolylneuraminic acid and method of procuding the same 失效含有N-甘氨酰氨基酸的甘氨酸及其处理方法
公开(公告)号：EP0264889A3
公开(公告)日：1989-11-29
申请号：EP87115283.1
申请日：1987-10-19
申请人： MECT CORPORATION
发明人： Ogawa, Tomoya , Numata, Masaaki , Sugimoto, Mamoru , Shibayama, Shohei , Yoshimura, Shoji , Ito, Masayoshi , Shitori, Yoshiyasu
IPC分类号： C07H15/10
CPC分类号： C07H15/10
摘要： The present invention provides ganglioside-related compounds expressed by the following formula: (wherein R 1 denotes a hydrogen atom or SiR 3 R 4 R 5 (wherein R 3 and R 4 each denotes a methyl or phenyl group, and R 5 denotes a tertiary butyl or dimethylphenylmethyl group), and R 2 denotes a hydrogen atom, a trityl group, or
(wherein M denotes an alkali metal atom)) and methods of producing the same. These ganglioside-related compounds are useful as markers for the early detection of cancer and in the immunotherapy for cancer.-
公开(公告)号：EP0219070B1
公开(公告)日：1989-06-21
申请号：EP86114034.1
申请日：1986-10-10
申请人： MECT CORPORATION
CPC分类号： C07H15/04
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公开(公告)号：EP0194563A3
公开(公告)日：1988-06-01
申请号：EP86102857
申请日：1986-03-05
申请人： MECT Corporation
发明人： Shibayama, Shohei , Matsuzaki, Yuzi , Yoshimura, Shoji , Ito, Masayoshi , Shitori, Yoshiyasu , Ogawa, Tomoya
CPC分类号： C07H15/26
摘要： This invention provides a novel compound having a formula such as
This invention also provides a process for preparing such a compound. The novel compound has excellent immunological activity.-
9.发明公开Glycolipid containing N-glycolylneuraminic acid and method of procuding the same 失效N-Glykoneuraminsäureenthaltendes Glykolipid und Verfahren zu dessen Herstellung。
公开(公告)号：EP0264889A2
公开(公告)日：1988-04-27
申请号：EP87115283.1
申请日：1987-10-19
申请人： MECT CORPORATION
发明人： Ogawa, Tomoya , Numata, Masaaki , Sugimoto, Mamoru , Shibayama, Shohei , Yoshimura, Shoji , Ito, Masayoshi , Shitori, Yoshiyasu
IPC分类号： C07H15/10
CPC分类号： C07H15/10
摘要： The present invention provides ganglioside-related compounds expressed by the following formula:
(wherein R 1 denotes a hydrogen atom or SiR 3 R 4 R 5 (wherein R 3 and R 4 each denotes a methyl or phenyl group, and R 5 denotes a tertiary butyl or dimethylphenylmethyl group), and R 2 denotes a hydrogen atom, a trityl group, or
(wherein M denotes an alkali metal atom)) and methods of producing the same. These ganglioside-related compounds are useful as markers for the early detection of cancer and in the immunotherapy for cancer.摘要翻译： 本发明提供由下式表示的神经节苷脂相关化合物：
（其中R表示氢原子或SiR 3 R 4 R 5（其中R 3和R 4各自表示甲基或苯基，R 5表示叔丁基或二甲基苯基甲基）， R2表示氢原子，三苯甲基或者CHEM（其中M表示碱金属原子））及其制造方法。 这些神经节苷脂相关化合物可用作早期检测癌症和癌症免疫治疗的标志物。 -
公开(公告)号：EP0219070A3
公开(公告)日：1987-09-16
申请号：EP86114034
申请日：1986-10-10
申请人： MECT CORPORATION
CPC分类号： C07H15/04
摘要： This invention provides a novel process for preparing a compound represented by the formula
In accordance with this invention, the compound is prepared by reacting a compound represented by the formula
with glycolic acid in the presence of dicyclohexylcarbodiimide. The compound (2) is a useful precursor for the preparation of N-glycolylneuraminic acid:
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